“…BACKGROUND: The effects of age and interval between vaccine doses on COVID-19 are incompletely understood, yet critical for public health policy. METHODS: This analysis evaluated the effectiveness of an mRNA-1273 50 μg booster (3(rd) dose) in ∼17,000 boosted participants in the phase 3 coronavirus efficacy (COVE) trial who previously received 2-doses of 100 µg mRNA-1273 during the randomized placebo-controlled phase (mRNA-1273, 1st dose July-Oct 2020), or open label phase (placebo-mRNA-1273, 1st dose Dec 2020-Apr 2021). …”
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“…INTRODUCTION: sustaining high rates of retention is critical for management of HIV clients, newly initiated antiretroviral therapy (ART). …”
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“…BACKGROUND: The NOD-, LRR- and pyrin domain‑containing 3 (NLRP3) inflammasome is a critical component of the innate immune system. It has been known to play an important role in the carcinogenesis and prognosis of breast cancer patients. …”
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“…The cost of neonatal critical care is not captured in the HES APC data, which may cause underestimation of the cost differences between the comparison group and the infertility groups. …”
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“…The observation of flares of autoimmune disease after application of G-CSF emphasizes the need for critical evaluation of the role of G-CSF in immunoablative regimens.…”
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“…The compression program PPMd, based on PPM (Prediction by Partial Matching), for generic data and Gencompress for DNA, are the best performers among the compression algorithms we have used, although the difference in performance, as measured by statistical indexes, between them and the other algorithms depends critically on the data set and may not be as large as expected. …”
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“…These findings indicate that there is a critical particle-cell ratio above which alterations appear in the dynamics of reproduction of influenza viruses. …”
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“…Observations from our own laboratories, as well as those of others, have demonstrated the critical role of histocompatibility gene products in governing the cell-cell interactions concerned with development and regulation of immune responses in several species (8–12). …”
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“…The basal metabolism increased from an average of 60 Cal. per kilo(3/4) at an environmental temperature of 40°C. to 128 Cal. per kilo(3/4) at 21°C. No indication of a critical temperature was found. 10. The partial efficiency, i.e. the increase in net energy per unit of the corresponding increase in food energy, seemed dependent on the environmental temperature, reaching a maximum of 72 per cent of the available energy at 38°C. and decreasing to 57 per cent at 21°C. and to an average of 60 per cent at 40°C. 11. …”
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“…In the normal cell a graded reaction of the membrane develops with increasing strength of stimulation until a critical level of depolarization, which is about 40 mv. 13. …”
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“…Beyond that range the membrane threshold for conducted responses of the cell soma rises, the impulses become smaller, and partial conduction in the soma-axon boundary region occurs. At a critical depolarization level which may be maintained for many minutes, all conduction ceases. …”
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“…Although no decision can be yet made between these, much evidence indicates that inward currents increase acidity in some critical part of the protoplasm, while outward ones decrease acidity.…”
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“…More importantly, this analysis identified a set of previously unknown genes potentially involved in critical steps associated with fruit development that can now be subjected to functional testing.…”
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“…AIMS/HYPOTHESIS: The α subunit of the amiloride-sensitive epithelial sodium channel (α ENaC) is critical for the expression of functional channels. …”
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“…OBJECTIVES: To test the performance of the new humidifier at different ventilator settings in a lung model, and to compare this new humidifier with a conventional active humidifier in ventilator-treated critically ill patients. MATERIALS AND METHODS: The humidifier (Humid-Heat; Louis Gibeck AB, Upplands Väsby, Sweden) consists of a supply unit with a microprocessor and a water pump, and a humidification device, which is placed between the Y-piece and the endotracheal tube. …”
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“…Understanding consumer willingness to share data is critical to advancing this model. OBJECTIVE: The objective was to characterize consumer willingness to share PCHR data for health research and the conditions and contexts bearing on willingness to share. …”
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“…BACKGROUND: An understanding of the factors that predict retention and website use are critical to the development of effective Web-based weight loss interventions. …”
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“…The non-deamidated N146 residue, NH(2)-terminal domain and COOH-terminal extension are also of critical importance to the maintenance of αB-crystallin chaperone activity.…”
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“…Yet, at a very fundamental level, the problems are the same-the fight is against distress, disability, and premature death; against human exploitation and for human development and self-actualisation; against the callousness to critical concerns in regimes and scientific power centres. …”
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“…Time proved to be a critical factor, with shorter interventions generally achieving larger impacts and greater adherence. …”
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