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  1. 304561
    “…BACKGROUND: For patients with complex care needs, engagement in disease management activities is critical. Chronic illnesses touch almost every person in the United States. …”
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    High Touch and High Tech (HT2) Proposal: Transforming Patient Engagement Throughout the Continuum of Care by Engaging Patients with Portal Technology at the Bedside
  2. 304562
    “…BACKGROUND: Acute kidney injury (AKI) is a common complication in the critically ill patients and associated with a substantial morbidity and mortality. …”
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    Online Artículo Texto
    Early versus late initiation of renal replacement therapy in patients with acute kidney injury-a systematic review & meta-analysis of randomized controlled trials
  3. 304563
    “…Included studies were independently appraised by two reviewers. The McMaster Critical Review Forms were used to assess methodological quality and identify sources of bias. …”
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    Outcomes of dysvascular partial foot amputation and how these compare to transtibial amputation: a systematic review for the development of shared decision-making resources
  4. 304564
    “…BACKGROUND: Mitochondria are abundant organelles critical for energy metabolism and brain function. …”
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    Online Artículo Texto
    Cerebrospinal fluid cell-free mitochondrial DNA is associated with HIV replication, iron transport, and mild HIV-associated neurocognitive impairment
  5. 304565
    “…Accurate and rapid detection of MDR-TB is critical for timely initiation of treatment. Line Probe Assay (LPA) is a qualitative in vitro diagnostic test based on DNA-STRIP technology for the identification of the M. tuberculosis complex and its resistance to rifampicin (RMP) and/or isoniazid (INH). …”
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    Evaluation of genotype MTBDRplus VER 2.0 line probe assay for the detection of MDR-TB in smear positive and negative sputum samples
  6. 304566
    “…Obtaining reliable, nationally representative prevalence estimates is critical to address the issue, but methodological and resource challenges have impeded this goal. …”
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    Online Artículo Texto
    Estimating infertility prevalence in low-to-middle-income countries: an application of a current duration approach to Demographic and Health Survey data
  7. 304567
    “…Therefore, identifying the concerns of different stakeholders and how they use health care social media when confronted with huge amounts of health-related messages posted by users is a critical problem. OBJECTIVE: We aimed to develop a new content analysis method using text mining techniques applied in health care social media to (1) identify different health care stakeholders, (2) determine hot topics of concern, and (3) measure sentiment expression by different stakeholders. …”
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    Understanding Health Care Social Media Use From Different Stakeholder Perspectives: A Content Analysis of an Online Health Community
  8. 304568
    “…The International Society of Sports Nutrition (ISSN) provides an objective and critical review related to the intake of protein for healthy, exercising individuals. …”
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    International Society of Sports Nutrition Position Stand: protein and exercise
  9. 304569
    “…BACKGROUND: Amyloid beta (Aβ) oligomers play a critical role in the pathogenesis of Alzheimer’s disease (AD) and represent a promising target for drug development. …”
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    Elucidating the Aβ42 Anti-Aggregation Mechanism of Action of Tramiprosate in Alzheimer’s Disease: Integrating Molecular Analytical Methods, Pharmacokinetic and Clinical Data
  10. 304570
    “…Understanding the behavioral factors suppressing the uptake of HIV prevention services is a critical step in informing strategies to improve interventions to combat the ongoing HIV pandemic among MSM. …”
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    Perceptions of HIV Seriousness, Risk, and Threat Among Online Samples of HIV-Negative Men Who Have Sex With Men in Seven Countries
  11. 304571
    “…BACKGROUND: Disability-adjusted life years (DALYs) provide a summary measure of health and can be a critical input to guide health systems, investments, and priority-setting in Ethiopia. …”
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    National disability-adjusted life years (DALYs) for 257 diseases and injuries in Ethiopia, 1990–2015: findings from the global burden of disease study 2015
  12. 304572
    “…Similarly, microbial transformations of drugs can change their pharmacokinetic properties, be critical for prodrug activation, and lead to undesirable side effects or loss of efficacy. …”
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    Chemical transformation of xenobiotics by the human gut microbiota
  13. 304573
    “…OBJECTIVES: Post-operative pain control is critical to successful outcomes following outpatient anterior cruciate ligament (ACL) reconstruction. …”
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    Femoral Nerve Blockade versus Adductor Canal Nerve Blockade with Anterior Cruciate Ligament Reconstruction: A Prospective, Randomized Clinical Trial
  14. 304574
    “…CONCLUSION: HPM down-regulates protein phosphorylation of MEK1, ERK1/2 and CREB, and mRNA expression of MEK, ERK and CREB, inhibiting activation of the MEK/ERK/CREB signaling pathway in the spinal cord of CIVP rats, which is possibly a critical central mechanism of the analgesic effect of HPM.…”
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    Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats
  15. 304575
    por Mikami, Koichi, Sturdy, Steve
    Publicado 2017
    “…Consequently, involvement of wider patient communities beyond rare disease communities will be critical for continuing discussions about patients’ involvement in regulatory and commissioning processes, and to consider how patients and their support organizations can best work with other stakeholders – including companies, regulators and policymakers – to ensure access to effective medicines.…”
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    Patient organization involvement and the challenge of securing access to treatments for rare diseases: report of a policy engagement workshop
  16. 304576
    “…The putative target, TP53INP1, showed an inverse expression relationship with miR-524-5p; direct TP53INP1 targeting was confirmed in luciferase assays. miR-524-5p-induced TP53INP1 downregulation enhanced cell proliferation, suppressed apoptosis, and upregulated the expression of pluripotency genes, all of which are critical early events of the reprogramming process. …”
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    miR-524-5p of the primate-specific C19MC miRNA cluster targets TP53IPN1- and EMT-associated genes to regulate cellular reprogramming
  17. 304577
    “…An adequate assessment (Verlinden et al., 2015) is critical and ensures the best available level of care and effective treatment. …”
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    Trauma and post-traumatic stress disorder among psychiatric inpatient children and adolescents
  18. 304578
    “…Animal studies have shown that chronically elevated stress mediators may lead to alterations in brain development through mechanisms of accelerated loss of neurons, delays in myelination, or abnormalities in developmentally appropriate neural synaptic pruning. Critical periods of brain development represent time-windows of elevated synaptic plasticity, mediating vulnerability, or establishing resilience to stress. …”
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    Neuroendocrine responses to early life stress and trauma and susceptibility to disease
  19. 304579
    “…For over two months he was in a critical medical condition because of septicaemia, he suffered acute pain, and every two weeks had a series of surgeries (skin transplantations). …”
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    Refugee children and adolescents in Greece: two case reports
  20. 304580
    “…Herewith we provide complementary new insights into IGF2 dysregulation mechanisms as a critical process in prostate tumorigenesis.…”
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    Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4
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