“…The early identification and management of treatment-related symptoms are critical to prevent symptom distress due to unmanaged symptoms. …”
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“…Maintenance of DNA integrity is critical for cancer prevention. Many studies have identified susceptibility loci and genetic variants in cervical cancer. …”
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“…The relationship between shorter gestation and children’s BP has not yet been explored to identify i) critical windows using nonlinear piecewise models or ii) combined with other early life risk factors such as prenatal lead exposure. …”
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“…In addition, over the past few decades, we have seen various social and healthcare changes that have raised critical questions about their ongoing roles in regulating marijuana and alcohol use. …”
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“…CONCLUSION: The BARC index performed better than existing tools in predicting 1-year mortality. Critically, the risk score only requires routinely collected non-specialist information which, therefore, could help identify patients seen in primary care that may benefit from palliative care. …”
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“…As with all focus group discussions, establishment of ground rules and employing both a skilled facilitator and a notetaker who could troubleshoot technology issues were critical to the success of CMC focus group discussions. …”
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“…IMPORTANCE: Patterns in emergency department (ED) use by rural populations may be an important indicator of the health care needs of individuals in the rural United States and may critically affect rural hospital finances. OBJECTIVE: To describe urban and rural differences in ED use over a 12-year period by demographic characteristics, payers, and characteristics of care, including trends in ambulatory care–sensitive conditions and ED safety-net status. …”
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“…Although lung cancer is the leading cause of cancer-related death worldwide and IL-17A was found to play a critical role in lung cancer, there is little knowledge concerning the association between the other five members of the IL-17 family and lung cancer. …”
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“…The real-time evaluations of ROS state can prove critical in developing new therapies and stratifying patients to therapies that are affected by tumor ROS. …”
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“…Neutrophils display similar GFP-Lc3 associations, but genetic modulation of the neutrophil/macrophage balance and ablation experiments show that macrophages are critical for the defense response. Deficiency of atg5 reduces GFP-Lc3 recruitment and impairs host resistance, in contrast to atg13 deficiency, indicating that Lc3-Salmonella association at this stage is independent of the autophagy preinitiation complex and that macrophages target Salmonella by Lc3-associated phagocytosis (LAP). …”
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“…Insulin is critical for lipid synthesis and inhibition of lipolysis. …”
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“…A HC regimen of 25 mg every 6 hrs for 24 hrs followed by 15 mg every 6 hrs resulted in cortisol levels that are consistently similar or above those observed in critically-ill subjects. The data calls into question the current practice of using excessive peri-op doses of HC.References 1. …”
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“…CONCLUSIONS: The present study clarifies that the A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop conducts critical regulatory effects on the malignant progression of glioma cells, which provides a novel molecular target for glioma therapy. …”
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“…IMPORTANCE: Nutrition during pregnancy is a critical dimension not only for women’s health but also for the lifelong health of the offspring. …”
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“…BACKGROUND: Conflicting data have reported beneficial effects of crystalloids, hyper-oncotic albumin (20%ALB), and iso-oncotic albumin (5%ALB) in critically ill patients. Although hyper-oncotic albumin may minimize lung injury, recent studies have shown that human albumin may lead to kidney damage proportional to albumin concentration. …”
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“…Participant retention and testing of persons reporting illness are critical elements for system improvement.…”
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“…DATA EXTRACTION AND SYNTHESIS: The methodological quality of included studies was assessed using The Joanna Briggs Institute’s Critical Appraisal Checklist for Prevalence and Incidence Studies. …”
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“…Invasive procedures were also common; 2673 residents (9.8%) were attended for life-threatening critical care (1672 women [8.6%] vs 1001 men [12.7%]; P < .001), and 210 (0.8%) received mechanical ventilation (113 women [0.6%] vs 97 men [1.2%]; P < .001). …”
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“…Alterations to the microbiome may play a critical role in obesity by affecting energy extraction from food and subsequent energy metabolism and fat storage. …”
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“…Expanding understanding of the risks that lead to poor outcomes and which protective factors contribute to resilience in children may be critical to improving disparities. METHODS AND FINDINGS: The Drakenstein Child Health Study is a population-based birth cohort in the Western Cape, South Africa. …”
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