“…Given that conventional coagulation indicators usually require more than 1 hour after admission to yield results—a limitation that frequently prevents the ability for clinicians to make appropriate interventions during the optimal therapeutic window—it is clearly of vital importance to develop prediction models that can rapidly identify ATC; such models would also facilitate ancillary resource management and clinical decision support. Using the critical care Emergency Rescue Database and further collected data in ED, a total of 1385 patients were analyzed and cases with initial international normalized ratio (INR) values >1.5 upon admission to the ED met the defined diagnostic criteria for ATC; nontraumatic conditions with potentially disordered coagulation systems were excluded. …”
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“…Rapid scale-up and strengthening of routine immunization services to reach children and to deliver missed doses to older children is also critically needed to close immunity gaps and prevent future outbreaks.…”
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“…To explore the mechanism by which JZ-1 regulates autophagy, western blotting and real-time quantitative PCR (qRT-PCR) were used to determine the expression of phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway proteins and to detect changes in critical molecules in the pathway after the application of a PI3K inhibitor. …”
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“…An ns2 mutant virus was unable to replicate in the liver or induce hepatitis in wt mice, but was highly pathogenic in RNase L−/− mice. Thus, RNase L is a critical cellular factor for protection against viral infection of the liver and the resulting hepatitis. …”
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“…Current evidence favors the possibility that there are inherited and/or acquired multiple abnormalities in the receptor—adenylate cyclase—cyclic AMP system of all effector cells that are critical in the organization of immune reactivities. …”
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“…In Subchapter 1.3 we critically discuss these recent developments that will, in the future, enable the multiplex identification and quantification of microorganisms directly on their biological matrix with unprecedented speed, low cost, and sensitivity. …”
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“…These data illustrate the critical need for continuous monitoring and aggressive management of ICH-associated risk factors. …”
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“…Stress may also be caused by organizational factors, such as depletion of personal protection equipment, concerns about not being able to provide competent care if deployed to new area, concerns about rapidly changing information, lack of access to up-to-date information and communication, lack of specific drugs, the shortage of ventilators and intensive care unit beds necessary to care for the surge of critically ill patients, and significant change in their daily social and family life. …”
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“…The study community advisory board and scientific advisors provided critical input on study design. Recruitment began in October 2019 (n=29 participants as of submission) and data collection will continue through 2022, with publication of baseline results anticipated summer 2021. …”
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“…BACKGROUND: The correct dating of pregnancy is critical to support timely decisions and provide obstetric care during birth. …”
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“…CONCLUSIONS: Phospho-S134-GR is a critical downstream effector of p38 MAPK signaling and TNBC migration/invasion, survival, and stemness properties. …”
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“…These results suggest a critical revision of how we counsel and manage women with PCOS. …”
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“…Despite fluid resuscitation and use of vasopressors, her hypotension persisted and she remained in critical condition. She was treated as a case of myxedema coma and started on full replacement dose thyroid hormone with 120 mcg IV levothyroxine daily and liothyronine 5 mcg every 8 hours. …”
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“…Although new targeted therapies are emerging, among breast cancer subtypes TNBC continues to carry the worst prognosis and therefore developing a greater understanding of the links between IR signaling and TNBC progression is critical. The aim of this study is to understand the role of IR-A and IR-B on proliferation, metastasis and metabolism in breast cancer cells. …”
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“…Background: GATA3 encodes a transcription factor critical for embryonic development of the parathyroid glands, kidney, inner ear, thymus, and the central nervous system. …”
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“…Qualitative studies were appraised by 2 different reviewers using the Critical Appraisal Skills Programme checklist. Extracted data were synthesized narratively. …”
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“…NSS are seen both state- and trait-related features of schizophrenia and thus critical to identify schizophrenia subtypes. Although association between NSS and cognitive performance is well recognized in schizophrenia, the links between these subtle neurological sensory integration/motor deficits and cognitive abilities to represent space (spatial memory) has not been studied yet. …”
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“…BACKGROUND: Adolescence is a critical period for the emergence of psychopathology and risk behaviors, including psychotic symptoms and suicidal behavior. …”
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“…SI was strongly connected to pessimism (SV= .69); social anxiety (SV= .41); and self-criticalness/worthlessness (SV= .39). The correlation stability coefficient for the strength was (cor = 0.7) = 0.672, suggesting robustness of the findings. …”
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“…In additional to demographic data and clozapine and G-CSF details, Clinical Global Impression severity scale (CGI-S) was used to evaluate psychopathology severity during four critical turning points: before and after clozapine introduction, after agranulocytosis episode and after clozapine rechallenge. …”
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