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  1. 304821
    “…The expression of miR-27a-3p and DiGeorge syndrome critical region 8 (DGCR8) was examined by RT-qPCR after transfection with E6 overexpressing plasmid or E6 siRNA. …”
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    HPV16 E6 enhances the radiosensitivity in HPV-positive human head and neck squamous cell carcinoma by regulating the miR-27a-3p/SMG1 axis
  2. 304822
    “…Inclusion criteria were: peer‐reviewed articles published in scientific journals, any design, published in English, participants born with a CP±L aged up to age 18 years who completed speech input processing assessments compared with normative data and/or a control or other comparison group. Critical Appraisal Skills Programme (CASP) checklists were used to quality appraise included studies. …”
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    Speech input processing in children born with cleft palate: A systematic literature review with narrative synthesis
  3. 304823
    “…Macroautophagy/autophagy plays a critical role in the pathogenesis of various human diseases including neurodegenerative disorders such as Parkinson disease (PD) and Huntington disease (HD). …”
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    A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducers
  4. 304824
    por Nakamura, Tomoka, Cohen, Adam L, Schwartz, Stephanie, Mwenda, Jason M, Weldegebriel, Goitom, Biey, Joseph N M, Katsande, Reggis, Ghoniem, Amany, Fahmy, Kamal, Rahman, Hossam Abdel, Videbaek, Dovile, Daniels, Danni, Singh, Simarjit, Wasley, Annemarie, Rey-Benito, Gloria, de Oliveira, Lucia, Ortiz, Claudia, Tondo, Emmanuel, Liyanage, Jayantha B L, Sharifuzzaman, Mohammad, Grabovac, Varja, Batmunkh, Nyambat, Logronio, Josephine, Heffelfinger, James, Fox, Kimberly, De Gouveia, Linda, von Gottberg, Anne, Du Plessis, Mignon, Kwambana-Adams, Brenda, Antonio, Martin, El Gohary, Samaa, Azmy, Aya, Gamal, Asmaa, Voropaeva, Elena, Egorova, Ekaterina, Urban, Yulia, Duarte, Carolina, Veeraraghavan, Balaji, Saha, Samir, Howden, Ben, Sait, Michelle, Jung, Sangoun, Bae, Songmee, Litt, David, Seaton, Shila, Slack, Mary, Antoni, Sebastien, Ouattara, Mahamoudou, Van Beneden, Chris, Serhan, Fatima
    Publicado 2021
    “…Maintaining case-based, active surveillance with laboratory confirmation for prioritized vaccine-preventable diseases remains a critical component of the global agenda in public health. …”
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    The Global Landscape of Pediatric Bacterial Meningitis Data Reported to the World Health Organization–Coordinated Invasive Bacterial Vaccine-Preventable Disease Surveillance Network, 2014–2019
  5. 304825
    “…Establishing generalizability, or lack thereof, is critical to devise strategies facilitating the development of clinically useful predictive tests. …”
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    Proteomic signatures predict preeclampsia in individual cohorts but not across cohorts – implications for clinical biomarker studies
  6. 304826
    “…Two reviewers independently extracted the data and critically appraised the study quality. Heterogeneity was quantified with I(2). …”
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    EGb in the Treatment for Patients with VCI: A Systematic Review and Meta-Analysis
  7. 304827
    “…Although non-invasive tests (NITs) are critical to early detection of the development of liver fibrosis, the prognostic role of NITs remains unclear due to the limited types of NITs and liver outcomes explored in previous studies. …”
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    Non-invasive tests for predicting liver outcomes in chronic hepatitis C patients: A systematic review and meta-analysis
  8. 304828
    “…Thus, we suggest our model as a tool for addressing critical challenges and unsolved problems in female diseases, such as endometriosis, uterine cancer and female infertility, in a personalised manner. …”
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    Three-dimensional microengineered vascularised endometrium-on-a-chip
  9. 304829
    “…Further research remains critical to identify interventions toward improved early childhood growth in challenging conditions. …”
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    Effect of scheduled antimicrobial and nicotinamide treatment on linear growth in children in rural Tanzania: A factorial randomized, double-blind, placebo-controlled trial
  10. 304830
    “…When therapists move towards the patient (personal), the display changes smoothly to show critical performance information. Furthermore, therapists can use their hand as a virtual stethoscope to display detailed measures about a specific body segment/joint (intimate). …”
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    Proximity-aware interactive displays for rehabilitation centres
  11. 304831
    “…However, suicide risk assessment among youth via eHealth platforms in school settings represents a critical research gap. On the basis of the findings of this review, we provide specific recommendations for future research, including the need to focus on the needs of diverse youth.…”
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    School-Based Suicide Risk Assessment Using eHealth for Youth: Systematic Scoping Review
  12. 304832
    “…Recent studies have shown the critical function and potential clinical applications of circular RNAs (circRNAs) in osteosarcoma. …”
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    Clinicopathologic significance and prognostic value of circRNAs in osteosarcoma: a systematic review and meta-analysis
  13. 304833
    “…BACKGROUND: With the revolutionary progress of immune checkpoint inhibitors (ICIs) achieved in non-small cell lung cancers (NSCLC), identifying patients benefiting from ICIs becomes critical and urgent. The associations of genomic alterations in protein tyrosine phosphatase receptor-type (PTPRs) and ICIs responses are unknown. …”
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    Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squamous NSCLC
  14. 304834
    “…Nevertheless, a clear disconnect exists between its mRNA and protein levels, indicating that its post-translational regulation may be critical in maintaining its protein levels. Similarly, AURKA is vastly overexpressed in all stages of prostate cancer (PCa), including castration-resistant PCa (CRPC) and neuroendocrine PCa (NEPC), although its transcripts are only increased in ~ 15% of cases, hinting at additional mechanisms of deregulation. …”
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    Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models
  15. 304835
    Publicado 2021
    “…Strict and standardized cytogenetic monitoring is critical for early detection, precise diagnosis, and treatment of these patients.…”
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    伴Ph阳性附加染色体异常慢性髓性白血病的生物学特征及疗效分析
  16. 304836
    por Lee, Jaedong, Kwag, Jeehyun
    Publicado 2021
    “…Thus, identifying the molecular targets of AβO involved in LTP inhibition is critical for developing therapeutics for AD. Endocannabinoid (eCB) synthesis and release, a process collectively called eCB mobilization by hippocampal CA1 pyramidal cells, is known to facilitate LTP induction. eCB can be mobilized either by postsynaptic depolarization in an intracellular Ca(2+) concentration ([Ca(2+)](i))-dependent pathway or by group 1 metabotropic glutamate receptor (mGluR) activation in a phospholipase Cβ (PLCβ)-dependent pathway. …”
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    Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer’s amyloidosis
  17. 304837
    “…BACKGROUND: People living with dementia (PLWD) and caregivers are adversely impacted by lack of meaningful activity leading to worse symptoms and impaired quality-of-life. There is a critical need to develop effective and well-tolerated treatments that mitigate clinical symptoms, engage PLWD and support caregiver wellbeing. …”
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    Effects of the tailored activity program (TAP) on dementia-related symptoms, health events and caregiver wellbeing: a randomized controlled trial
  18. 304838
    “…The pre-defined maternal outcomes we collected were mode of delivery (vaginal or by caesarean section), severe or critical COVID-19 (as defined by the authors), symptomatic COVID-19, maternal death, maternal hospital admission, ICU admission, mechanical ventilation, ECMO and maternal pneumonia. …”
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    Treatment of COVID-19 in pregnant women: A systematic review and meta-analysis
  19. 304839
    “…These results emphasise the importance of robust evaluation of the trade-offs of the wider health, welfare and economic effects of NPI to support both resource allocation and the prioritisation of time-critical health services directly impacted in a pandemic, such as cancer care.…”
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    Economic impact of avoidable cancer deaths caused by diagnostic delay during the COVID-19 pandemic: A national population-based modelling study in England, UK
  20. 304840
    “…Regarding clinical evolution, 5 patients were classified as critical and transferred to ICU; all had a CT with GGO. 3 of them needed respiratory support and 1 needed only supplementary oxygen. …”
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    CLINICAL AND RADIOLOGICAL FINDINGS IN PEDIATRIC PATIENTS WITH ACUTE LEUKEMIA DURING COVID-19 INFECTION - WHAT HAVE WE LEARNED?
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