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  1. 304941
    “…GSEA analysis showed that these differentially expressed RNAs correlate with several critical biological processes such as “ncRNA metabolic process”, “ncRNA processing”, “ribosome biogenesis”, “rRNAs metabolic process”, “tRNA metabolic process” and “tRNA processing”, which might be participating in the progression of COPD. …”
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    Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease
  2. 304942
    “…CONCLUSIONS: Drawing on the critical perspectives of people with substance use disorder, our findings provide important and actionable information on individual and environmental barriers and facilitators of PrEP uptake among rural PWID at high risk for HIV infection. …”
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    Pre-Exposure Prophylaxis Barriers, Facilitators and Unmet Need Among Rural People Who Inject Drugs: A Qualitative Examination of Syringe Service Program Client Perspectives
  3. 304943
    “…Independent predictors of in-hospital death were age (hazards ratio (HR) 1.05, 95% confidence interval (CI) 1.03–1.08, p < 0.001), body mass index (HR 0.93, 95% CI 0.89–0.98, p = 0.004), COVID-19 severity (severe versus mild/moderate HR 3.67, 95% CI 1.30–10.4, p = 0.014, critical versus mild/moderate HR 12.1, 95% CI 4.57–32.2, p < 0.001), active neoplasia (HR 2.58, 95% CI 1.48–4.50, p < 0.001), chronic obstructive pulmonary disease (HR 2.47; 95% CI 1.15–5.27, p = 0.020), respiratory rate (HR 1.06, 95% CI 1.02–1.11, p = 0.008), heart rate (HR 1.03, 95% CI 1.01–1.04, p < 0.001), and any heparin treatment (HR 0.35, 95% CI 0.18–0.67, p = 0.001). …”
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    Effect of heparin treatment on pulmonary embolism and in-hospital death in unvaccinated COVID-19 patients without overt deep vein thrombosis
  4. 304944
    “…BACKGROUND: Maternal knowledge that motivates improvements in critical perinatal health behaviors has the potential to significantly reduce maternal and neonatal mortality. …”
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    Optimizing knowledge and behavioral intention of women and their partners in the perinatal period in South Africa: a randomized control trial study protocol in the Tshwane district, Gauteng province, South Africa
  5. 304945
    “…CONCLUSIONS: Full parent-child engagement is critical for the success of mHealth interventions. …”
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    The Aim2Be mHealth Intervention for Children With Overweight or Obesity and Their Parents: Person-Centered Analyses to Uncover Digital Phenotypes
  6. 304946
    “…N(6)-methyladenosine (m(6)A) RNA modification is known to play a critical role in regulating autophagy. In this study, it was found that SQSTM1/p62 (sequestosome 1), an autophagy receptor, was significantly downregulated in two human keratinocyte cells lines with short-term high-glucose treatment, as well as in the epidermis of diabetic patients and a db/db mouse model with long-term hyperglycemia. …”
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    m(6)A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin
  7. 304947
    “…IMPORTANCE: Fetal life and infancy might be critical periods for predisposing individuals to develop cardiovascular disease in adulthood. …”
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    Associations of Fetal and Infant Growth Patterns With Early Markers of Arterial Health in School-Aged Children
  8. 304948
    “…BACKGROUND: Among self-care measures, the self-monitoring of blood glucose (SMBG) is a critical component for checking blood glucose levels. …”
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    Real-world Benefits of Diabetes Management App Use and Self-monitoring of Blood Glucose on Glycemic Control: Retrospective Analyses
  9. 304949
    “…In the analysis, some theoretical hypotheses of the performance structure of Tibet's education policy are tested, and the empirical data are combed to give an overall view of the criticism contained in these studies. This study constructs the model blueprint of the performance structure of Tibetan language education language policy, which provides reference and suggestions for future researchers. …”
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    INVESTIGATION ON SATISFACTION AND EMOTIONAL BEHAVIOR CHANGES OF TIBETAN EDUCATIONAL LANGUAGE POLICY IN GANZI TIBETAN AUTONOMOUS PREFECTURE
  10. 304950
    por Qi, Baohua
    Publicado 2022
    “…From the tendency of public sentiment, microblog public opinion shows criticism, populism, nationalism, pragmatism, patriotism and justice. …”
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    ON THE EXPRESSION AND GUIDANCE OF NETWORK EMOTION IN EMERGENCIES FROM THE CHANGE OF EMOTIONAL BEHAVIOR -- TAKING THE RAINSTORM IN ZHENGZHOU ON JULY 20 AS AN EXAMPLE
  11. 304951
    “…These participants were assigned to three subgroups depending on disease severity as defined by the WHO ordinal scale of clinical improvement (outpatient, severe, or critical). Our control cohort comprised of 182 anonymised age-matched and sex-matched plasma samples that were available from the Mayo Clinic Biorepository and banked before the COVID-19 pandemic. …”
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    Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study
  12. 304952
    “…Finally, the phosphorylation of some kidney proteins, such as spectrin, L-lactate dehydrogenase, and ATPases, was found, which is critical for their functions. In summary, the SEC-RPLC-MS approach was developed for the identification of rat kidney proteins and is especially applicable for the identification of PTM proteins. …”
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    尺寸排阻-反相液相色谱-质谱联用技术在大鼠肾脏翻译后修饰蛋白质鉴定中的应用
  13. 304953
    “…This study provides critical information on the frequencies and distributions of HLA alleles and haplotypes in the Kinh Vietnamese population, accounting for more than 85% of Vietnamese citizens. …”
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    Allele and Haplotype Frequencies of HLA-A, -B, -C, and -DRB1 Genes in 3,750 Cord Blood Units From a Kinh Vietnamese Population
  14. 304954
    “…CONCLUSIONS: The COVID-19 pandemic has had severe, nationwide effects on healthcare delivery, exacerbating the deleterious effects of an existing, critical nursing shortage. To the best of our knowledge, the present study is the first detailed analysis of this phenomenon and its effects on a surgical division. …”
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    Drastic increase in hospital labor costs led to a sustained financial loss for an academic vascular surgery division during the coronavirus disease 2019 pandemic
  15. 304955
    “…BACKGROUND: Although coma is commonly encountered in critical care, worldwide variability exists in diagnosis and management practices. …”
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    The Curing Coma Campaign International Survey on Coma Epidemiology, Evaluation, and Therapy (COME TOGETHER)
  16. 304956
    “…BACKGROUND: Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. …”
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    Selective block of sensory neuronal T-type/Cav3.2 activity mitigates neuropathic pain behavior in a rat model of osteoarthritis pain
  17. 304957
    “…PURPOSE: Positron emission tomography (PET) attenuation correction (AC) in positron emission tomography‐magnetic resonance (PET/MR) scanners constitutes a critical and barely explored issue in spinal cord investigation, mainly due to the limitations in accounting for highly attenuating bone structures which surround the spinal canal. …”
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    The impact of MR‐based attenuation correction in spinal cord FDG‐PET/MR imaging for neurological studies
  18. 304958
    “…The finding that the effect size did not differ between low and high CoE indicate urgent need to refine current EBM critical appraisal methods.…”
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    High quality (certainty) evidence changes less often than low‐quality evidence, but the magnitude of effect size does not systematically differ between studies with low versus high‐quality evidence
  19. 304959
    “…Eligible studies were critically appraised for methodological quality. The primary outcome measure was Knee Society Function Score. …”
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    Functional outcomes in patient specific instrumentation vs. conventional instrumentation for total knee arthroplasty; a systematic review and meta-analysis of prospective studies
  20. 304960
    “…Other substrates of CD38 include nicotinamide adenine dinucleotide phosphate and nicotinamide mononucleotide, a critical NAD+ precursor in the salvage pathway. NAD+ is an important coenzyme involved in several metabolic pathways and is a required cofactor for the function of sirtuins (SIRTs) and poly (adenosine diphosphate-ribose) polymerases. …”
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    TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
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