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  1. 304981
    “…BACKGROUND: Evidence-based clinical practice guidelines regarding high-flow nasal cannula (HFNC) use for respiratory support in critically ill children are lacking. Therefore, we aimed to determine the risk factors for early HFNC failure to reduce the failure rate and prevent adverse consequences of HFNC failure in children with acute respiratory dysfunction. …”
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    Analysis of risk factors for the failure of respiratory support with high-flow nasal cannula oxygen therapy in children with acute respiratory dysfunction: A case–control study
  2. 304982
    “…CONCLUSIONS: Complement activation is critically involved in the development of subretinal fibrosis, partially through C5a–C5aR-mediated EMT in RPE cells. …”
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    Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells
  3. 304983
    “…CONCLUSION: This study revealed the critical role and mechanism of METTL1-mediated tRNA m(7)G modification in regulating NBL progression, providing new insights for developing therapeutic approaches for NBL patients. …”
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    METTL1 promotes neuroblastoma development through m(7)G tRNA modification and selective oncogenic gene translation
  4. 304984
    “…The study will randomise 40 SARs-CoV-2-positive patients receiving advanced respiratory support in a critical care area. Randomisation will be via 1:1 allocation to usual care plus nebulised unfractionated heparin 6 hourly to day 10 while receiving advanced respiratory support or usual care only. …”
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    The CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial
  5. 304985
    “…BACKGROUND: Natural language processing (NLP) methods are powerful tools for extracting and analyzing critical information from free-text data. MedTaggerIE, an open-source NLP pipeline for information extraction based on text patterns, has been widely used in the annotation of clinical notes. …”
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    Multicenter Validation of Natural Language Processing Algorithms for the Detection of Common Data Elements in Operative Notes for Total Hip Arthroplasty: Algorithm Development and Validation
  6. 304986
    “…BACKGROUND: Notch signaling is highly conserved and critically involved in cell differentiation, immunity, and survival. …”
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    Macrophage Notch1 inhibits TAK1 function and RIPK3-mediated hepatocyte necroptosis through activation of β-catenin signaling in liver ischemia and reperfusion injury
  7. 304987
    “…RESULTS: RESULTS Prominent German experts for justice: Patrick BUROW, Jens GNISA/President Law-Association/Germany, Torsten SCHLEIF/Amtsrichter, Hans-Jochen VOGEL/Ex-Minister, Stephan ZANTKE/Richter reflect in their books fundamental-criticism of German justice [5]. Inst.-Ecol.-Med./IUM investigated psychopathology of juridical-offices&law-court in Munich (Amtsgericht). …”
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    On social psychopathology: Example with German justice
  8. 304988
    “…CONCLUSION: Most cases of C. auris infection were found in critical patients with the most common presentation being candidemia. …”
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    P385 Candida auris: a growing threat to global health
  9. 304989
    “…Early recognition of cutaneous entry of Fusarium in severely immunocompromised patients is critical to initiate early treatment. The aim of this presentation is to present two cases of disseminated fusariosis in severe oncohematological patients with favorable outcomes. …”
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    P194 Disseminated fusariosis in h ematological malignancies with favo rable outcomes
  10. 304990
    “…But, recently increasing cases have been reported in patients with non-classical risk factors and non-neutropenic patients like diabetes mellitus, chronic lung disease, HIV infection, critically ill patients, etc. According to ISHAM these non-classical risk factors should be included in EORTC/MSG host criteria for diagnosis of invasive aspergillosis. …”
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    P144 The uncommon meets the common: Invasive Aspergillosis and tuberculosis co-infection in non-neutropenic patients— arare association
  11. 304991
    “…Although, ruling out evidence of TB is critical in diagnostic algorithms for CPA, in rare cases, CPA may occur in patients with active TB. …”
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    P143 Incidence of chronic pulmonary aspergillosis in a cohort of bacteriologically confirmed TB patients at a tertiary hospital in Ghana
  12. 304992
    “…Defer the need for histopathology diagnosis in critically ill children Cardiac involvement is a life-threatening marker Early diagnosis prevents life threatening complications.…”
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    P41 Spotting the needle amongst the haystack - when asthma isn’t asthma
  13. 304993
    por Alkoky, Hoda, Hall, Frances
    Publicado 2022
    “…Bosentan was considered but cautioned against, given also diagnosed with aortic stenosis. 1980s Calcinosis Recurrent calcinotic fingers and the olecranon processes with cellulitis and no osteomyelitis. 1999-2007 Critical ischemia of legs In 1999, she developed left leg ischemia.  …”
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    OA13 Multiple complication in the lifetime of limited cutaneous systemic sclerosis
  14. 304994
    por Hao, Xiuling, Wei, Huiqiang
    Publicado 2022
    “…OBJECTIVE: Acute lung injury (ALI) increases sepsis morbidity and mortality. LncRNA H19 plays a critical role in sepsis. miR-107 is highly-expressed and TGFβ type III receptor (TGFBR3) is poorly-expressed in sepsis, yet their roles in sepsis development require further investigation. …”
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    LncRNA H19 alleviates sepsis-induced acute lung injury by regulating the miR-107/TGFBR3 axis
  15. 304995
    “…Thus, understanding the exact effects of cuproptosis-related genes in LIHC and determining their prognosticvalue is critical. However, the prognostic model of LIHC based on cuproptosis-related genes has not been reported. …”
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    System analysis based on the cuproptosis-related genes identifies LIPT1 as a novel therapy target for liver hepatocellular carcinoma
  16. 304996
    “…Primary care providers and medical specialists are critical gatekeepers who can identify fractures and initiate proven osteoporosis interventions. …”
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    The clinician’s guide to prevention and treatment of osteoporosis
  17. 304997
    “…In this pilot study, we aimed to investigate our clinical mid-term outcome and 3D accuracy as well as their possible correlation, including identifying aspects critical to reaching optimal correction results. METHODS: From October 2018 to January 2020, we used PSIs for 12 corrective osteotomies of the upper extremity in 11 bones of 8 patients (congenital or posttraumatic deformities in 2 elbows, 3 forearms, 3 distal radii). …”
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    3D accuracy and clinical outcomes of corrective osteotomies with patient-specific instruments in complex upper extremity deformities: an approach for investigation and correlation
  18. 304998
    “…BACKGROUND: Instruments to critically appraise randomised controlled trials (RCTs) are based on evidence from meta-epidemiological studies. …”
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    Empirical evidence of study design biases in nutrition randomised controlled trials: a meta-epidemiological study
  19. 304999
    “…More than half (55.2%) of our patients had severe COVID-19, 18.8% had moderate, 16.2% had critical, 5.2% had mild, and 4.5% were asymptomatic. …”
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    ALTERED PLASMA CYTOKINE CONCENTRATIONS ARE ASSOCIATED WITH THE CLINICAL SEVERITY OF PATIENTS WITH COVID-19
  20. 305000
    “…BACKGROUND: Financial risk-sharing through community-based health insurance is a critical component of universal health coverage. However, its development is a great challenge, not only due to low enrollment but also due to the high dropout rate of members from the program, which threatens its sustainability. …”
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    Factors influencing drop-out of households from community based health insurance membership in rural districts of Gurage Zone, Southern Ethiopia: Community based case-control study
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