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  1. 305021
    “…CONCLUSIONS: Finding innovative strategies to detect BSMM at risk of contracting or transmitting HIV is critical to eliminating HIV disparities in this community. …”
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    Social Media Communication and Network Correlates of HIV Infection and Transmission Risks Among Black Sexual Minority Men: Cross-sectional Digital Epidemiology Study
  2. 305022
    “…CONCLUSIONS: Our findings suggest that patterns of never-smoking status associated with sociodemographic and clinical characteristics are different across sex and race/ethnicity among patients with lung cancer. Such data are critical to increasing awareness and expediting diagnosis of this disease.…”
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    Sociodemographic and clinical characteristics associated with never-smoking status in patients with lung cancer: findings from a large integrated health system
  3. 305023
    “…BACKGROUND: Swine influenza A viruses (SwIAVs) pose an economic and pandemic threat, and development of novel effective vaccines is of critical significance. We evaluated the performance of split swine influenza A virus (SwIAV) H1N2 antigens with a plant-derived nanoparticle adjuvant alone (Nano-11) [Nano11-SwIAV] or in combination with the synthetic stimulator of interferon genes (STING) agonist ADU-S100 (NanoS100-SwIAV). …”
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    A split influenza vaccine formulated with a combination adjuvant composed of alpha-d-glucan nanoparticles and a STING agonist elicits cross-protective immunity in pigs
  4. 305024
    “…As treatments continue to evolve, consistent reporting of validated patient-reported outcome measures is critically important to facilitate analysis with existing RCT evidence. …”
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    What is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
  5. 305025
    “…In this context, ERβ was selected as a druggable target for endometriosis due to its critical role in progression. Therefore, selective targeting of ERβ without inhibiting ERα activity would be a new paradigm for endometriosis treatment to overcome the low efficacy and adverse effects of hormonal endometriosis therapy. …”
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    Oleuropein suppresses endometriosis progression and improves the fertility of mice with endometriosis
  6. 305026
    “…The tumor necrosis factor (TNF) signaling pathway, the hypoxia-inducible factor 1 (HIF-1) signaling pathway, and the nuclear factor kappa-B (NF-κB) signaling pathway was signaling pathways that G.s Maxim mediated anti-anoxia effects. The critical targets were TNF, Jun proto-oncogene (JUN), tumor protein p53 (TP53), and threonine kinase 1 (AKT1). …”
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    Preliminary verification of the anti-hypoxia mechanism of Gentiana straminea maxim based on UPLC-triple TOF MS/MS and network pharmacology
  7. 305027
    “…Our preliminary findings suggest that rehabilitation loading is critical to structural and functional outcomes following surgically repairing the Achilles tendon. …”
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    Surgically Repairing Achilles Tendon Ruptures Restores Plantar Flexor Function Better Than Non- Surgical Treatment in a Rat Model
  8. 305028
    “…CONCLUSIONS: In two large prospective multicenter cohorts of critically ill patients with TBI, levels of PaO(2) and FiO(2) varied widely across centers during the first seven days after ICU admission. …”
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    High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI
  9. 305029
    “…CONCLUSIONS: PARP1 mediated ADPR is critical to the 'early phase' events of muscle cell differentiation. …”
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    OR07-5 PARP1 Contributes to the Glucocorticoid Receptor Transcriptional Response And Influences the Skeletal Muscle Phenotype
  10. 305030
    “…With increasing rates of obesity, diabetes, and NAFLD it is critical to examine the mechanisms by which in utero exposure to PFOA contributes to the development of metabolic syndrome in offspring. …”
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    RF22 | PSUN318 Hepatocytes Exposed to PFOA Prior to Differentiation Leads to Epigenetic Changes in Genes Linked With NAFLD
  11. 305031
    “…OBJECTIVE: This overview of systematic reviews aims to critically appraise and consolidate evidence from current systematic reviews (SRs)/meta-analyses on the effects of exercise interventions on cancer-related fatigue (CRF) in breast cancer patients. …”
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    Effects of exercise interventions on cancer-related fatigue in breast cancer patients: an overview of systematic reviews
  12. 305032
    “…Via integration with HPLC-FLD, ER-DSM was used to rapidly extract and analyze trace-level BPs in six types of boxed drinks. Critical factors were optimized individually, including the type of eluent and elution time and volume, which influenced the enrichment effect. …”
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    磁性三维氮掺杂碳纳米材料对6种双酚类化合物的吸附性能及其在泡腾分散微萃取中的应用
  13. 305033
    “…Deficient handling and procedures in the transport/slaughter processes can be critically scrutinized and corrected only when personnel are sufficiently educated. …”
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    Impact of Procedures and Human-Animal Interactions during Transport and Slaughter on Animal Welfare of Pigs: A Systematic Literature Review
  14. 305034
    “…However, when applied to critically ill patients with shock, its measurement may be affected by changes in FiO(2) and PaO(2) and potential associated O(2) diffusion between urine and ureteric or bladder tissue. …”
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    Effects of changes in inspired oxygen fraction on urinary oxygen tension measurements
  15. 305035
    “…Two of them, KLF2 and HOXB6, are critical molecules in the gene interaction network of endometriosis. …”
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    Gene expression analysis in endometriosis: Immunopathology insights, transcription factors and therapeutic targets
  16. 305036
    “…BACKGROUND: Invasive fungal infection (IFI) is associated with high mortality rates in critically ill patients. Appropriate antifungal treatment is crucial for managing IFI. …”
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    347. Azole Activity against Filamentous Fungi Causing Invasive Infections in Patients from ICU and Non-ICU Units (2017-2021)
  17. 305037
    “…An electronic reference customized for local practice and rapidly updated by ASPs offers critical support for front-line clinicians. DISCLOSURES: Martha B. …”
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    961. Pandemic Hits: Evaluation of an Antimicrobial Stewardship Program Website for Hospital Communication During the COVID-19 Pandemic
  18. 305038
    “…[Figure: see text] [Figure: see text] CONCLUSION: Frequent surveillance testing of NH staff during a pandemic is critical due to many factors that drive reluctance to speak up about potential symptoms. …”
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    1401. Evaluating Barriers and Potential Solutions to Speaking Up About COVID-19 Symptoms: A Survey Among Nursing Home Workers
  19. 305039
    “…BACKGROUND: Schools, depending on their access to and quality of water, sanitation and hygiene (WASH) and the implementation of healthy behaviours, can be critical for the control and spread of many infectious diseases, including COVID-19. …”
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    Kenyan school book knowledge for water, sanitation, hygiene and health education interventions: Disconnect, integration or opportunities?
  20. 305040
    “…BACKGROUND: Acute hypoxemic respiratory failure (AHRF) is a leading concern in critically ill patients. Experimental and clinical data suggest that early sedation with volatile anesthestics may improve arterial oxygenation and reduce the plasma and alveolar levels of markers of alveolar epithelial injury and of proinflammatory cytokines. …”
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    Isoflurane vs. propofol for sedation in invasively ventilated patients with acute hypoxemic respiratory failure: an a priori hypothesis substudy of a randomized controlled trial
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