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  1. 305081
    “…Furthermore, exogenous rhBMP2 alone, at the concentration found in MMN-CM collected from D5 to D10 cultures, failed to induce new bone, indicating that other factors in the CM play a critical role in that osteoinductive microenvironment. …”
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    Bone marrow stromal cells generate an osteoinductive microenvironment when cultured on titanium–aluminum–vanadium substrates with biomimetic multiscale surface roughness
  2. 305082
    “…We concluded that we identified a significant, functional, and robust risk variant block covering entire KTN1 that might play a critical role in the risk and pathogenesis of schizophrenia.…”
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    A significant, functional and replicable risk KTN1 variant block for schizophrenia
  3. 305083
    “…Abnormal expression and prognosis of critical downstream molecules were analyzed using gene databases and molecular experiments. qRT-PCR and western blot analysis was performed to verify the expression of candidate genes. …”
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    The hsa_circ_0000276-ceRNA regulatory network and immune infiltration in cervical cancer
  4. 305084
    “…CER-001-treated patients had reduced risk for the onset and progression to severe AKI (stage 2 or 3) and, in a subset of critically ill patients, a reduced need for organ support and shorter ICU length of stay. …”
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    Beneficial effects of recombinant CER-001 high-density lipoprotein infusion in sepsis: results from a bench to bedside translational research project
  5. 305085
    por Zhang, Ming, Ferrari, Raffaele, Tartaglia, Maria Carmela, Keith, Julia, Surace, Ezequiel I, Wolf, Uri, Sato, Christine, Grinberg, Mark, Liang, Yan, Xi, Zhengrui, Dupont, Kyle, McGoldrick, Philip, Weichert, Anna, McKeever, Paul M, Schneider, Raphael, McCorkindale, Michael D, Manzoni, Claudia, Rademakers, Rosa, Graff-Radford, Neill R, Dickson, Dennis W, Parisi, Joseph E, Boeve, Bradley F, Petersen, Ronald C, Miller, Bruce L, Seeley, William W, van Swieten, John C, van Rooij, Jeroen, Pijnenburg, Yolande, van der Zee, Julie, Van Broeckhoven, Christine, Le Ber, Isabelle, Van Deerlin, Vivianna, Suh, EunRan, Rohrer, Jonathan D, Mead, Simon, Graff, Caroline, Öijerstedt, Linn, Pickering-Brown, Stuart, Rollinson, Sara, Rossi, Giacomina, Tagliavini, Fabrizio, Brooks, William S, Dobson-Stone, Carol, Halliday, Glenda M, Hodges, John R, Piguet, Olivier, Binetti, Giuliano, Benussi, Luisa, Ghidoni, Roberta, Nacmias, Benedetta, Sorbi, Sandro, Bruni, Amalia C, Galimberti, Daniela, Scarpini, Elio, Rainero, Innocenzo, Rubino, Elisa, Clarimon, Jordi, Lleó, Alberto, Ruiz, Agustin, Hernández, Isabel, Pastor, Pau, Diez-Fairen, Monica, Borroni, Barbara, Pasquier, Florence, Deramecourt, Vincent, Lebouvier, Thibaud, Perneczky, Robert, Diehl-Schmid, Janine, Grafman, Jordan, Huey, Edward D, Mayeux, Richard, Nalls, Michael A, Hernandez, Dena, Singleton, Andrew, Momeni, Parastoo, Zeng, Zhen, Hardy, John, Robertson, Janice, Zinman, Lorne, Rogaeva, Ekaterina
    Publicado 2018
    “…Further, investigating the functional links within the C6orf10/LOC101929163/HLA-DRB1 pathway will be critical to better define age-dependent pathogenesis of frontotemporal dementia and amyotrophic lateral sclerosis.…”
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    A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers
  6. 305086
    por Passamonti, Francesco, Cattaneo, Chiara, Arcaini, Luca, Bruna, Riccardo, Cavo, Michele, Merli, Francesco, Angelucci, Emanuele, Krampera, Mauro, Cairoli, Roberto, Della Porta, Matteo Giovanni, Fracchiolla, Nicola, Ladetto, Marco, Gambacorti Passerini, Carlo, Salvini, Marco, Marchetti, Monia, Lemoli, Roberto, Molteni, Alfredo, Busca, Alessandro, Cuneo, Antonio, Romano, Alessandra, Giuliani, Nicola, Galimberti, Sara, Corso, Alessandro, Morotti, Alessandro, Falini, Brunangelo, Billio, Atto, Gherlinzoni, Filippo, Visani, Giuseppe, Tisi, Maria Chiara, Tafuri, Agostino, Tosi, Patrizia, Lanza, Francesco, Massaia, Massimo, Turrini, Mauro, Ferrara, Felicetto, Gurrieri, Carmela, Vallisa, Daniele, Martelli, Maurizio, Derenzini, Enrico, Guarini, Attilio, Conconi, Annarita, Cuccaro, Annarosa, Cudillo, Laura, Russo, Domenico, Ciambelli, Fabrizio, Scattolin, Anna Maria, Luppi, Mario, Selleri, Carmine, Ortu La Barbera, Elettra, Ferrandina, Celestino, Di Renzo, Nicola, Olivieri, Attilio, Bocchia, Monica, Gentile, Massimo, Marchesi, Francesco, Musto, Pellegrino, Federici, Augusto Bramante, Candoni, Anna, Venditti, Adriano, Fava, Carmen, Pinto, Antonio, Galieni, Piero, Rigacci, Luigi, Armiento, Daniele, Pane, Fabrizio, Oberti, Margherita, Zappasodi, Patrizia, Visco, Carlo, Franchi, Matteo, Grossi, Paolo Antonio, Bertù, Lorenza, Corrao, Giovanni, Pagano, Livio, Corradini, Paolo
    Publicado 2020
    “…Older age (hazard ratio 1·03, 95% CI 1·01–1·05); progressive disease status (2·10, 1·41–3·12); diagnosis of acute myeloid leukaemia (3·49, 1·56–7·81), indolent non-Hodgin lymphoma (2·19, 1·07–4·48), aggressive non-Hodgkin lymphoma (2·56, 1·34–4·89), or plasma cell neoplasms (2·48, 1·31–4·69), and severe or critical COVID-19 (4·08, 2·73–6·09) were associated with worse overall survival. …”
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    Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
  7. 305087
    por Côté, Pierre, Hartvigsen, Jan, Axén, Iben, Leboeuf-Yde, Charlotte, Corso, Melissa, Shearer, Heather, Wong, Jessica, Marchand, Andrée-Anne, Cassidy, J. David, French, Simon, Kawchuk, Gregory N., Mior, Silvano, Poulsen, Erik, Srbely, John, Ammendolia, Carlo, Blanchette, Marc-André, Busse, Jason W., Bussières, André, Cancelliere, Carolina, Christensen, Henrik Wulff, De Carvalho, Diana, De Luca, Katie, Du Rose, Alister, Eklund, Andreas, Engel, Roger, Goncalves, Guillaume, Hebert, Jeffrey, Hincapié, Cesar A., Hondras, Maria, Kimpton, Amanda, Lauridsen, Henrik Hein, Innes, Stanley, Meyer, Anne-Laure, Newell, David, O’Neill, Søren, Pagé, Isabelle, Passmore, Steven, Perle, Stephen M., Quon, Jeffrey, Rezai, Mana, Stupar, Maja, Swain, Michael, Vitello, Andrew, Weber, Kenneth, Young, Kenneth J., Yu, Hainan
    Publicado 2021
    “…At the summit, participants critically appraised the literature and synthesized the evidence. …”
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    The global summit on the efficacy and effectiveness of spinal manipulative therapy for the prevention and treatment of non-musculoskeletal disorders: a systematic review of the literature
  8. 305088
    por Neves, Ana Luísa, Jácome, Cristina, Taveira-Gomes, Tiago, Pereira, Ana Margarida, Almeida, Rute, Amaral, Rita, Alves-Correia, Magna, Mendes, Sandra, Chaves-Loureiro, Cláudia, Valério, Margarida, Lopes, Cristina, Carvalho, Joana, Mendes, Ana, Ribeiro, Carmelita, Prates, Sara, Ferreira, José Alberto, Teixeira, Maria Fernanda, Branco, Joana, Santalha, Marta, Vasconcelos, Maria João, Lozoya, Carlos, Santos, Natacha, Cardia, Francisca, Moreira, Ana Sofia, Taborda-Barata, Luís, Pinto, Cláudia Sofia, Ferreira, Rosário, Morais Silva, Pedro, Monteiro Ferreira, Tania, Câmara, Raquel, Lobo, Rui, Bordalo, Diana, Guimarães, Cristina, Espírito Santo, Maria, Ferraz de Oliveira, José, Cálix Augusto, Maria José, Gomes, Ricardo, Vieira, Inês, da Silva, Sofia, Marques, Maria, Cardoso, João, Morete, Ana, Aroso, Margarida, Cruz, Ana Margarida, Nunes, Carlos, Câmara, Rita, Rodrigues, Natalina, Abreu, Carmo, Albuquerque, Ana Luísa, Vieira, Claúdia, Santos, Carlos, Páscoa, Rosália, Chaves-Loureiro, Carla, Alves, Adelaide, Neves, Ângela, Varanda Marques, José, Reis, Bruno, Ferreira-Magalhães, Manuel, Almeida Fonseca, João
    Publicado 2021
    “…A better understanding of the characteristics of users and nonusers is critical to design solutions that are effectively integrated in patients’ daily lives, and to ensure that these equitably reach out to different groups of patients, thus improving rather than entrenching health inequities. …”
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    Determinants of the Use of Health and Fitness Mobile Apps by Patients With Asthma: Secondary Analysis of Observational Studies
  9. 305089
    “…Therefore, electronic contact tracing and surveillance have critical roles in decreasing COVID-19 transmission; yet, if not conducted properly, these methods can rapidly become a bottleneck for synchronized data collection, case detection, and case management. …”
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    Leveraging Polio Geographic Information System Platforms in the African Region for Mitigating COVID-19 Contact Tracing and Surveillance Challenges: Viewpoint
  10. 305090
    por Liu, Xinxue, Munro, Alasdair P S, Feng, Shuo, Janani, Leila, Aley, Parvinder K, Babbage, Gavin, Baxter, David, Bula, Marcin, Cathie, Katrina, Chatterjee, Krishna, Dejnirattisai, Wanwisa, Dodd, Kate, Enever, Yvanne, Qureshi, Ehsaan, Goodman, Anna L., Green, Christopher A, Harndahl, Linda, Haughney, John, Hicks, Alexander, van der Klaauw, Agatha A., Kwok, Jonathan, Libri, Vincenzo, Llewelyn, Martin J, McGregor, Alastair C, Minassian, Angela M., Moore, Patrick, Mughal, Mehmood, Mujadidi, Yama F, Holliday, Kyra, Osanlou, Orod, Osanlou, Rostam, Owens, Daniel R, Pacurar, Mihaela, Palfreeman, Adrian, Pan, Daniel, Rampling, Tommy, Regan, Karen, Saich, Stephen, Serafimova, Teona, Saralaya, Dinesh, Screaton, Gavin R, Sharma, Sunil, Sheridan, Ray, Sturdy, Ann, Supasa, Piyada, Thomson, Emma C, Todd, Shirley, Twelves, Chris, Read, Robert C., Charlton, Sue, Hallis, Bassam, Ramsay, Mary, Andrews, Nick, Lambe, Teresa, Nguyen-Van-Tam, Jonathan S, Cornelius, Victoria, Snape, Matthew D, Faust, Saul N
    Publicado 2022
    “…While high antibody tires are desirable in situations of high transmission of new variants of concern, the maintenance of immune responses that confer long-lasting protection against severe disease or death is also of critical importance. Policymakers may also consider adenoviral vector, fractional dose of mRNA, or other non-mRNA vaccines as third doses.…”
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    Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial.
  11. 305091
    “…Thus, IL-2 cancer immunotherapy has two critical drawbacks: potent activation of undesired IL-2Rα(+) cells and suboptimal pharmacokinetics with high C(max) and short half-life. …”
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    TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer
  12. 305092
    “…Examination of postmortem brains of participants with antemortem plasma p-tau levels remains critical to understanding comorbid and AD-specific contribution to these biomarker changes. …”
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    Global neuropathologic severity of Alzheimer’s disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels
  13. 305093
    “…The use of a countermovement is demonstrated to be critical to the achievement of greater jump heights, and this phenomenon may only need to exploit physical principles alone to be successful; amplification of muscle performance may not necessarily be a proximate reason for the use of this maneuver. …”
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    Predictive Simulations of Musculoskeletal Function and Jumping Performance in a Generalized Bird
  14. 305094
    “…BACKGROUND: Studies suggest that high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV) can prevent reintubation in critically ill patients with a low risk of extubation failure. …”
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    The efficacy of high-flow nasal cannula (HFNC) versus non-invasive ventilation (NIV) in patients at high risk of extubation failure: a systematic review and meta-analysis
  15. 305095
    “…BACKGROUND: Hemolysis is associated with increased mortality in patients with sepsis, ARDS, or therapy with extracorporeal membrane oxygenation (ECMO). To quantify a critical threshold of hemolysis in patients with ARDS and treatment with veno-venous ECMO, we aimed to identify cutoff values for cell-free hemoglobin (CFH) and haptoglobin (Hp) plasma concentrations associated with a significant increase in ICU mortality. …”
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    Potential of cell-free hemoglobin and haptoglobin as prognostic markers in patients with ARDS and treatment with veno-venous ECMO
  16. 305096
    “…We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. METHODS: We did a prospective cohort study across 23 hospitals in Spain. …”
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    Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study
  17. 305097
    “…With less economic independence, the free provision of appropriate menstrual products is critical for adolescent girls to access materials that allow them to effectively manage their menstruation. …”
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    Does distribution of menstrual products through community-based, peer-led sexual and reproductive health services increase use of appropriate menstrual products? Findings from the Yathu Yathu trial
  18. 305098
    “…Furthermore, the goal of an Aldrete score > 8 at PACU arrival was achieved significantly more often in monitored patients (MM 2830 [83%], OM: 2665 [81%], p = 0.004). Critical hypoxemia (S(p)O(2) < 90%) at PACU arrival had an overall low occurrence within propensity matched datasets and showed no difference between groups (MM: 161 [5%], OM 150 [5%], p = 0.755). …”
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    Risikofaktoren für postoperative Hypoxämie während des Transportes in den Aufwachraum und Einfluss von Transport-Monitoring: Eine retrospektive Propensity-Score-gematchte Datenbankanalyse
  19. 305099
    “…CONCLUSION: LTBP1 was correlated with immune cell infiltration and identified as the critical diagnostic maker for PAH. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12890-023-02584-4.…”
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    Bioinformatics analysis of the immune cell infiltration characteristics and correlation with crucial diagnostic markers in pulmonary arterial hypertension
  20. 305100
    “…Standardized EHR data, which capture MH conditions is critical for health systems to examine past and current trends for future surveillance. …”
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    Electronic health records identify timely trends in childhood mental health conditions
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