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  1. 305441
    “…For example, we observed that pericytes are in close proximity to SPP1(+)/KDR(+) capillary endothelial cells (cluster 9) and identified that VISFATIN- (ITGA5+ITGB1) and SPP1-CD44 are critical signaling pathways between these two cell populations in OA synovium (Fig. 3B). …”
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    Poster 116: Integrated scRNA-seq and spatial transcriptomics analysis uncovers distinct cellular populations and transcriptomes in human hip synovium between patients with femoroacetabular impingement and osteoarthritis.
  2. 305442
    “…DATA COLLECTION AND ANALYSIS: We used three‐stage maximum variation sampling to ensure diversity in terms of relevance of the study to the review objectives, richness of data, and coverage of critical contextual elements: setting (region, country income level), perspective (type of participant), and topic (prevention, detection, management). …”
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    Perceptions and experiences of the prevention, detection, and management of postpartum haemorrhage: a qualitative evidence synthesis
  3. 305443
    por Elsberg, Charles A.
    Publicado 1899
    “…In the last few decades, the advances made in all the branches of medicine—especially in pathology, bacteriology and surgery—have been due to a great extent to the generalization of the results of animal experimentation. To the careful and critical investigator, the results obtained in the animal experiment have always been of the greatest value in indicating to him the possibility of results to be obtained by similar procedures in the human body. …”
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    AN EXPERIMENTAL INVESTIGATION OF THE TREATMENT OF WOUNDS OF THE HEART BY MEANS OF SUTURE OF THE HEART MUSCLE
  4. 305444
    “…As the intervention is often claimed to have important health, nutrition, and societal effects beyond the removal of worms, we critically evaluated the evidence on benefits. OBJECTIVES: To summarize the effects of giving deworming drugs to children to treat soil‐transmitted helminths on weight, haemoglobin, and cognition; and the evidence of impact on physical well‐being, school attendance, school performance, and mortality. …”
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    Deworming drugs for soil‐transmitted intestinal worms in children: effects on nutritional indicators, haemoglobin, and school performance
  5. 305445
    “…Some micronutrients play critical roles in maintenance of the immune system, and routine supplementation could therefore be beneficial. …”
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    Micronutrient supplementation in adults with HIV infection
  6. 305446
    “…It is therefore important at this stage to establish the efficacy and safety of these programmes, and furthermore to address the critical factors that determine their success or failure. …”
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    Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
  7. 305447
    “…Improving preconception health before and between pregnancies is critical for reducing maternal and infant mortality and pregnancy-related complications. …”
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    Disparities in Preconception Health Indicators — 
Behavioral Risk Factor Surveillance System, 2013–2015, and Pregnancy Risk Assessment Monitoring System, 2013–2014
  8. 305448
    “…These agencies and organizations, including schools and youth-friendly health care providers, can help facilitate access to critically important education, health care, and high-impact, evidence-based interventions.…”
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    Youth Risk Behavior Surveillance — United States, 2017
  9. 305449
    “…Early diagnosis and appropriate referral to a specialist unit may be critical. Guidance regarding echocardiogram as a tool for detecting PAH in PSS patients would be helpful. …”
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    28. Acute pulmonary arterial hypertension in primary Sjögren’s syndrome with known cryptogenic organising pneumonia
  10. 305450
    por Bracha, H. Stefan
    Publicado 2006
    “…A research agenda for the DSM-V advocated the “development of a pathophysiologically based classification system”. The author critically reviews the neuroevolutionary literature on stress-induced and fear circuitry disorders and related amygdala-driven, species-atypical fear behaviors of clinical severity in adult humans. …”
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    Human brain evolution and the “Neuroevolutionary Time-depth Principle:” Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder
  11. 305451
    “…Mortality and/or need for Critical Care admission, from randomisation until ICU admission or hospital discharge, whatever occurs first, O2 saturation levels , from randomization until ICU admission or hospital discharge, whatever occurs first. …”
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    A prospective, randomized, controlled study assessing vagus nerve stimulation using the gammaCore®-Sapphire device for patients with moderate to severe CoViD-19 Respiratory Symptoms (SAVIOR): A structured summary of a study protocol for a randomised controlled trial”
  12. 305452
    “…PARTICIPANTS: Only critically ill adult patients that fulfill all of the inclusion criteria and none of the exclusion criteria will be included. …”
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    A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial
  13. 305453
    “…AIMS: In this work, the survival and mortality data of 54 consecutive patients admitted to the Intensive Care Unit (ICU) and suffering from severe respiratory insufficiency imputable to viral SARS - CoV - 2 infection were analyzed and shared, after a critical review of the evidence in order to optimize the most dedicated clinical and treatment strategy, for a future ‘targeted’ management in the care of the possible return flu outbreak. …”
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    Intensive care for seriously ill patients affected by novel coronavirus sars - CoV – 2: Experience of the Crema Hospital, Italy
  14. 305454
    “…Written informed consent will be taken for all recruited patients. Patients with a critical illness (WHO clinical improvement ordinal score > 5), documented significant liver disease/dysfunction (aspartate transaminase [AST] / alanine aminotransferase [ALT] > 240), myopathy and rhabdomyolysis (creatine phosphokinase [CPK] > 5x normal), allergy or intolerance to statins or aspirin, prior statin or aspirin use within 30 days, history of active gastrointestinal bleeding in past three months, coagulopathy, thrombocytopenia (platelet count < 100000/ dl), pregnancy, active breastfeeding, or inability to take oral or nasogastric medications will be excluded. …”
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    Atorvastatin and Aspirin as Adjuvant Therapy in Patients with SARS-CoV-2 Infection: A structured summary of a study protocol for a randomised controlled trial
  15. 305455
    “…Given her clinical deterioration, she was reviewed by the critical care team for consideration of transfer to higher-level care. …”
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    O03 A case of hyperinflammatory COVID-19 that responded to tocilizumab therapy
  16. 305456
    “…An early pathogenic mechanism of lung injury in mechanically ventilated, critically ill patients is inflammation-induced pulmonary fibrin deposition, leading to thrombosis of the microvasculature and hyaline membrane formation in the air sacs. …”
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    Nebulised heparin for patients with or at risk of acute respiratory distress syndrome: a multicentre, randomised, double-blind, placebo-controlled phase 3 trial
  17. 305457
    “…Of patients infected with Covid-19, about 15 % have severe illness and 5 % have critical illness (Emanuel et al. in N Engl J Med. 2020). …”
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    Modeling and tracking Covid-19 cases using Big Data analytics on HPCC system platform
  18. 305458
    “…Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases. …”
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    Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles
  19. 305459
    por Harrison, C, Gameiro, S, Boivin, J
    Publicado 2021
    “…In total 881 clicked on the survey link, 118 did not consent, 41 were excluded after data screening, 57 did not meet the inclusion criteria, 331 started the survey but did not complete it, 28 had missing data on critical variables (e.g., age) and 306 completed the survey (40.1% completion, 57 men, 249 women). …”
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    Patient willingness, preferences and decision-making about planning for three complete cycles of IVF/ICSI treatment
  20. 305460
    “…PARTICIPANTS: Patients of either sex between 18 to 60 years, ambulatory, willing to participate, with history (not more than 4 weeks) of positive RT-PCR for COVID-19 or IgM antibodies positivity for SARS CoV-2, but having negative RT-PCR for COVID-19 at the time of screening will be considered eligible for enrolment in the study. Critically ill patients with ARDS (acute respiratory distress syndrome), requiring invasive respiratory support in the intensive care unit, known case of any malignancy, immune-compromised state (e.g. …”
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    Safety and efficacy of Ayurvedic interventions and Yoga on long term effects of COVID-19: A structured summary of a study protocol for a randomized controlled trial
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