“…OBJECTIVES: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020. DATA SOURCES: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for impactful publications. …”
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“…The central role of vitamin D in the maintenance of calcium homeostasis is to increase the absorption of ingested calcium from the intestine. The critical importance of vitamin D in this process is noted in the causal link between vitamin D deficiency and rickets, as well as in studies using genetically modified mice including mice deficient in the vitamin D receptor (Vdr null mice) or in the cytochrome P‐450 enzyme, 25‐hydroxyvitamin D(3)‐1α‐ hydroxylase (CYP27B1) that converts 25‐hydroxyvitamin D(3) to the hormonally active form of vitamin D, 1,25‐dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] (Cyp27b1 null mice). …”
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“…Multidisciplinary care of critically ill patients has become an integral part of every modern health care system, ensuing improved care and reduced mortality. …”
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“…To describe the long-term evolution of the critically patient with COVID-19 and the need for invasive mechanical ventilation and orotracheal intubation (OTI), with or without tracheostomy. …”
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“…Hospitals and health care systems with active critical care organizations (CCOs) that unified ICU units before the onset of the COVID-19 Pandemic were better positioned to adapt to the demands of the pandemic, due to their established standardization of care and integration of critical care within the larger structure of the hospital or health care system. …”
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“…Nonetheless, materials scientists rarely take material criticality and reuse potential into account. In this work, we expand upon lists of “critical materials” generated by national and regional governments by showing that many materials are employed predominantly as alloying elements, which can be a deterrent to recovery and reuse at end of product life and, likely as a consequence, have low functional end-of-life recycling rates, among other problematic characteristics. …”
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“…Because organisms are also flexible enough to evolve, they arguably operate in a critical dynamical regime between order and chaos. …”
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“…In conclusion, YAP is a critical target in HCC therapy, and evodiamine can be an effective HCC anticancer drug by reducing the YAP level.…”
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“…Objective: In a few patients with mild COVID-19, there is a possibility of the infection becoming severe or critical in the future. This work aims to identify high-risk patients who have a high probability of changing from mild to critical COVID-19 (only account for 5% of cases). …”
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“…Objective: Evaluate the impact of a post-discharge critical care transition program (CTP) on intensive care unit (ICU) readmission, in-hospital mortality, and six-month survival. …”
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“…Mounting evidence suggests that during conscious states, the electrodynamics of the cortex are poised near a critical point or phase transition and that this near-critical behavior supports the vast flow of information through cortical networks during conscious states. …”
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“…The primary aim of this study was to investigate microvascular function in patients with critical coronavirus disease 2019. DESIGN: A prospective observational study was conducted in which patients with critical and severe COVID-19 were investigated during acute disease phase and at least 3 months after disease onset. …”
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