“…Conventional method of cell culture studies has been performed on two-dimensional substrates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…One characteristic of senescent cells documented very early in cell culture studies was an increase in cell size and total protein content, but whether this occurs in vivo is not known. …”
Enlace del recurso
Enlace del recurso

“…The protozoa were isolated from the rumen of sheep and either grown in vitro or inoculated into the rumen of ciliate-free sheep and maintained in natural conditions. In vitro culture studies showed that the enrichment of culture medium with the examined saccharides results in an increase in the number of ciliates in comparison to the control cultures. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This paper explored the effectiveness and safety of natural chemical biocide hydrogen peroxide (H(2)O(2)) for brown tide bloom control. Culture studies showed that H(2)O(2) at 1.6 mg L(−1) effectively eradicated high density A. anophagefferens within 24-hr, but caused no significant growth inhibition in the diatoms, prymnesiophytes, green algae and dinoflagellates of >2–3 μm cell sizes among 12 phytoplankton species tested over 1-week observation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: This cross-cultural study was designed to examine cultural differences in empathy levels of first-year medical students. …”
Enlace del recurso
Enlace del recurso

“…Here we show that clinically relevant sugammadex concentrations cause apoptotic/necrosis neuron death in primary cultures. Studies on the underlying mechanism revealed that sugammadex-induced activation of mitochondria-dependent apoptosis associates with depletion of neuronal cholesterol levels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We review how cell culture studies have revealed a number of different mechanisms whereby cells can be rendered less susceptible to the effects of Hsp90 inhibitor treatment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In pig ear fibroblast cell culture study, the demethylation of OPN promoter was found in dose-dependent response of 5-aza-dc treatment and followed the OPN mRNA reexpression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our data and the previous cell culture studies that say EGF triggers apoptosis in some cell lines suggest that the EGF-mediated modulation of PCD is likely conserved in C. elegans and humans.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Both animal model studies and human cell culture studies have shown a possible link between omega-3 fatty acids, zinc transporter levels and free zinc availability at cellular levels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, WNV infectious titers were reduced in CB-D28k-transfected cells. As in cell culture studies, WNV env ir was not co-localized with CB-D28k ir in the cortex of an infected WNV hamster, or in the hippocampus of an infected mouse. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Whether for cell culture studies of protein function, construction of mouse models to enable in vivo analysis of disease epidemiology, or ultimately gene therapy of human diseases, a critical enabling step is the ability to achieve finely controlled regulation of gene expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through in vivo genetic analysis and culture studies we show that inhibition of Activin signaling in the female UGS leads to a similar phenotype to that of retinoic acid treatment, namely bud formation in the absence of androgens. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The physiological mechanisms responsible for these proxy relationships are still unknown. This culture study investigates the impact of different seawater [Mg(2 +)] on calcification in two benthic foraminiferal species precipitating contrasting Mg/Ca(CC): Ammonia aomoriensis, producing low-Mg calcite and Amphistegina lessonii, producing intermediate-Mg calcite. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Adhesion of melanoma cells to fibronectin was critical in amplifying the fibroblast-derived NRG and HGF-mediated PI3K/AKT survival signaling in the melanoma cells following BRAF inhibition. In co-culture studies, combination treatment with inhibitors of BRAF/MET/HER kinase was ineffective at reversing the fibroblast-mediated therapeutic escape from BRAF inhibition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Lead intoxication in humans is characterized by cognitive impairments, particularly in the domain of memory, where evidence indicates that glutamatergic neurotransmission may be impacted. Animal and cell culture studies have shown that lead decreases the expression and activity of glutamine synthetase (GS) in astrocytes, yet the basis of this effect is uncertain. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further, using a T-ALL cell line, CCRF-CEM (CEM) cells, we show that CEM cells induce pulmonary remodeling in immunocompromised mice, suggesting potential interaction between these cells and lung fibroblasts. Co-culture studies suggested that fibroblasts-induced phenotypic and genotypic divergence in co-cultured CEM cells leading to diminished therapeutic responses in vitro. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In support of this, cell culture studies have detected microdomain-associated “raftophilic” proteins on LDs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Because axon growth and regeneration is impaired in familial amyloidotic polyneuropathy (FAP), a neurodegenerative disorder characterized by misfolding and deposition of mutant transthyretin (TTR) in the peripheral nervous system (PNS), we presently investigated the expression levels and the potential role for MMP-14 in this condition. By using cell culture studies, a mouse model of disease and human clinical samples, we observed that MMP-14: (i) is overexpressed in FAP nerves, correlating with TTR deposition; (ii) is upregulated in sciatic nerves from a preclinical transgenic mouse model, increasing with TTR deposition; (iii) levels in the PNS and plasma are rescued upon treatment of mice with anakinra or TTR siRNA, drugs acting over the IL-1 signaling pathway or TTR liver synthesis, respectively; (iv) increases in Schwann cells upon incubation with amyloid-like aggregates; and, finally, (v) is increased in plasma of FAP patients, correlating with disease progression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso