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  1. 1021
    “…The factor is already in clinical use and a large clinical trial showed that, if supplemented to an embryo culture medium, it leads to increased survival of embryos, especially in women with previous miscarriages. Animal and cell culture studies on isolated trophectoderm cells support an effect mainly on cellular expansion. …”
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    GM-CSF perturbs cell identity in mouse pre-implantation embryos
  2. 1022
    “…The study combined psychophysical testing with olfactory mucosa biopsy analysis, single-cell RNA-Sequencing (scRNA-Seq), and culture studies. RESULTS: We identified evidence for inflammation-associated changes in the OE stem cells of presbyosmic patients. …”
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    Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans
  3. 1023
    “…STUDY DESIGN: In vitro cell culture study. METHODS: The GNPs were synthesized and successfully conjugated with cetuximab and cisplatin. …”
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    A Promising, Novel Radiosensitizer Nanodrug Complex for Oral Cavity Cancer: Cetuximab and Cisplatin-Conjugated Gold Nanoparticles
  4. 1024
    “…Cell culture studies offer the unique possibility to investigate the influence of pharmacological treatments with quantified dosages applied for defined time durations on survival, morphological maturation, protein expression and function as well as the mutual interaction of various cell types. …”
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    Adjusting the neuron to astrocyte ratio with cytostatics in hippocampal cell cultures from postnatal rats: A comparison of cytarabino furanoside (AraC) and 5-fluoro-2’-deoxyuridine (FUdR)
  5. 1025
    “…Ex vivo transcorneal permeation was significantly enhanced for CS coated formulation. In vitro cell culture studies on corneal stromal fibroblasts revealed NPs biocompatibility with enhanced cellular uptake and improved antioxidant and anti-proliferative properties for the CS-coated formulation. …”
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    Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment
  6. 1026
    “…METHODS: We performed a series of cell culture studies, followed by their interrogation in patient-derived organoids to evaluate the synergistic effect of BBR and OPCs against CRC. …”
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    Berberine and Oligomeric Proanthocyanidins Exhibit Synergistic Efficacy Through Regulation of PI3K-Akt Signaling Pathway in Colorectal Cancer
  7. 1027
    “…Conventional in vitro culture studies do not reflect the rheological properties of CM. …”
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    Three-Dimensional Kidney-on-a-Chip Assessment of Contrast-Induced Kidney Injury: Osmolality and Viscosity
  8. 1028
    “…Here we will review rodent preclinical models of AD-DS and how these can be used for both in vivo and ex vivo (cultured cells and organotypic slice cultures) studies to understand the mechanisms that contribute to the early development of AD in people who have DS and test the utility of treatments to prevent or delay the development of disease.…”
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    Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches
  9. 1029
    por Priyanka, Seth, Pankaj
    Publicado 2022
    “…Brain autopsies and cell culture studies showed reduced expression of mortalin in Alzheimer’s, Parkinson’s, and HAND cases and deciphered the important role of mortalin in brain cells. …”
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    Insights Into the Role of Mortalin in Alzheimer’s Disease, Parkinson’s Disease, and HIV-1-Associated Neurocognitive Disorders
  10. 1030
    “…STUDY DESIGN: Cell culture study and animal study. METHODS: The detection of circ_0010235, microRNA-588 (miR-588), and homeobox protein A10 (HOXA10) was implemented via reverse transcription-quantitative polymerase chain reaction (RT-qPCR). …”
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    Circ_0010235 Regulates HOXA10 Expression to Promote Malignant Phenotypes and Radioresistance in Non-small Cell Lung Cancer Cells Via Decoying miR-588
  11. 1031
    “…Current evidence from cell culture studies showed that AnxA1 expression is correlated with NF-κB, which promotes migration by activating ERK phosphorylation. …”
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    A Cell-Based Systematic Review on the Role of Annexin A1 in Triple-Negative Breast Cancers
  12. 1032
    “…In this systematic review, 29 articles were identified that either analyzed EAAT2 expression in the AD human brain or used a human-derived cell culture. Studies were inconclusive as to whether EAAT2 was upregulated or downregulated in AD. …”
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    EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review
  13. 1033
    “…In vitro cell culture studies are common in the cancer research field, and reliable biomimetic 3D models are needed to ensure physiological relevance. …”
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    Decellularization of xenografted tumors provides cell-specific in vitro 3D environment
  14. 1034
    “…Besides, through deep signal transduction analyses and cell co-culture studies, we further disclosed that these GPNMB-high macrophage subpopulations, originating from monocytes, could also ineffectively retain T cells from activating by dendritic cells (DCs). …”
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    Integrated single-cell transcriptomic analyses reveal that GPNMB-high macrophages promote PN-MES transition and impede T cell activation in GBM
  15. 1035
    “…Disposable small-scale vessels are commonly used in cell culture studies in academia as well as early stages of bioprocess development. …”
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    A novel approach to noninvasive monitoring of dissolved carbon dioxide in small-scale cell culture processes
  16. 1036
    “…Blood samples were collected at different times for HPLC analysis, and 5-FU pharmacokinetic parameters were calculated. RESULTS: At cell culture study, in a certain concentration range, combination therapy showed synergistic effects (<0.05). …”
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    Effect of Ketorolac on Pharmacokinetics and Pharmacodynamics of 5-Fluorouracil: In Vivo and In Vitro Study
  17. 1037
    “…With a simple electrospinning setup and innovative writing strategies supported by simulation, we successfully overcame the intricate jet–field interactions while preserving high-fidelity template topographies, via excellent target recognition, with pattern features ranging from 100’s μm to 10’s cm. A 3D cell culture study ensured the anatomical compatibility of the so-made 3D scaffolds. …”
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    Self-Searching Writing of Human-Organ-Scale Three-Dimensional Topographic Scaffolds with Shape Memory by Silkworm-like Electrospun Autopilot Jet
  18. 1038
    “…Outcomes from a cross-cultural study. Educ Gerontol. 2020;46:284-293. DISCLOSURE: No significant relationships.…”
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    Older adults and sexual well-being: A qualitative study in Portugal and Slovenia
  19. 1039
    “…Outcomes from a cross-cultural study. Educ Gerontol. 2020;46:284-293. DISCLOSURE: No significant relationships.…”
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    Different cultures and sexual unwellness in older adults: A qualitative study with older populations from Slovenia and Portugal
  20. 1040
    “…In this study, cell culture studies using MIA PaCa-2 and BxPC-3 cells, followed by analysis in patient-derived organoids were performed to evaluate the anti-cancer effects of BBR in PDAC. …”
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    Berberine Overcomes Gemcitabine-Associated Chemoresistance through Regulation of Rap1/PI3K-Akt Signaling in Pancreatic Ductal Adenocarcinoma
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