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  1. 1081
    “…Furthermore, both our in vivo models and in vitro cell culture studies demonstrate that loss of Tak1 results in impaired activation of the downstream MAPK target p38, as well as diminished activation of the BMP/SMAD signaling pathway. …”
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    TAK1 Regulates Cartilage and Joint Development via the MAPK and BMP Signaling Pathways
  2. 1082
    “…Further, our model presents a framework for quantitative analyses of cell culture studies now extensively employed to investigate HCV infection.…”
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    Mathematical Model of Viral Kinetics In Vitro Estimates the Number of E2-CD81 Complexes Necessary for Hepatitis C Virus Entry
  3. 1083
    “…Primary cortical culture studies showed that chronic (5-day) exposure to nicotine stimulated ACSL6 mRNA expression. …”
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    ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure
  4. 1084
    “…By inhibiting the de novo production of CSPG following spinal cord injury, we demonstrated that this extracellular matrix, mainly known for its ability to inhibit axonal growth, serves as a critical template skewing the entering monocytes towards the resolving phenotype. In vitro cell culture studies demonstrated that this matrix alone is sufficient to induce such monocyte polarization. …”
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    The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair
  5. 1085
    “…Here we review results from human, animal and cell culture studies relevant to the ADE hypothesis. By understanding how human antibodies neutralize or enhance DENV, it will be possible to better evaluate existing vaccines and develop the next generation of novel vaccines.…”
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    The Human Antibody Response to Dengue Virus Infection
  6. 1086
    “…The availability of data in clinical, animal, and cell culture studies, however, has been quite limited. Many studies of virus infection kinetics have been based solely on measures of total or infectious virus count. …”
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    Quantification system for the viral dynamics of a highly pathogenic simian/human immunodeficiency virus based on an in vitro experiment and a mathematical model
  7. 1087
    “…Chicken embryo brain cell culture studies revealed that both HPAIV and LPAIV could infect cultivated embryonic brain cells, but in accordance with the absence of the necessary proteases, replication of LPAIV was limited. …”
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    Systemic virus distribution and host responses in brain and intestine of chickens infected with low pathogenic or high pathogenic avian influenza virus
  8. 1088
    “…Concentrations below 50 μM were determined as suitable RSV concentrations for both SLN and NLC in cell culture studies. RSV-NLC showed less fluorescence, indicating less ROS production in cytofluorometric studies. …”
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    Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications
  9. 1089
    “…Investigation of the mechanism in primary cell culture studies demonstrated that resveratrol treatment significantly protected endothelial cells against an in vitro ‘ischemia’ resulting in improved viability against oxygen and glucose deprivation (39.6±6.6% and 81.3±9.5% in vehicle and resveratrol treated cells, respectively). …”
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    Protection against Recurrent Stroke with Resveratrol: Endothelial Protection
  10. 1090
    por Knapp, Angela N.
    Publicado 2012
    “…However, an examination of culturing studies and in situ N(2) fixation rate measurements from marine euphotic, mesopelagic, and benthic environments indicates that while elevated concentrations of NO(−)(3) and/or NH(+)(4) can depress N(2) fixation rates, the process can continue at substantial rates in the presence of as much as 30μM NO(−)(3) and/or 200μM NH(+)(4). …”
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    The sensitivity of marine N(2) fixation to dissolved inorganic nitrogen
  11. 1091
    “…C/OK virus was able to infect both ferrets and pigs and transmit to naive animals by direct contact. Cell culture studies showed that C/OK virus displayed a broader cellular tropism than a human influenza C virus. …”
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    Isolation of a Novel Swine Influenza Virus from Oklahoma in 2011 Which Is Distantly Related to Human Influenza C Viruses
  12. 1092
    “…Each, have shown significant ADCC in the presence of the tumor cells grown in culture. Studies were performed to clarify at what stage in the development of the colon cancer do such TAA proteins begin to be expressed. …”
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    Nanocytology vs. Immunohistochemistry of Intestinal Colonocytes to Assess the Risk of Colon Cancer based on Field Cancerization - A Preliminary Report
  13. 1093
    “…OX40L expression was induced in the RPE cells stimulated with pro-inflammatory cytokines. In the co-culture studies, there was a significant reversal (20% to 30%) of the RPE-induced suppression of activated PBMCs when the ARPE cells were transfected with OX40L. …”
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    OX40 ligand expression abrogates the immunosuppressive function of retinal pigment epithelium
  14. 1094
    “…To test whether–as predicted by our earlier co-culture studies–absence of neuroligin-2 impairs beta cell function, we compared glucose-stimulated insulin secretion by islets from mutant and wild-type mice. …”
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    Altered Pancreatic Islet Function and Morphology in Mice Lacking the Beta-Cell Surface Protein Neuroligin-2
  15. 1095
    “…Those SLEV-Palenque strains form a highly distinct phylogenetic clade within the SLEV species. Cell culture studies of SLEV-Palenque versus epidemic SLEV (MSI-7) revealed no growth differences in insect cells but a clear inability of SLEV-Palenque to replicate in cells from birds, cotton rats, and free-tailed bats permissive for MSI-7 replication. …”
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    Provenance and Geographic Spread of St. Louis Encephalitis Virus
  16. 1096
    “…CLN3 encodes a putative lysosomal transmembrane protein with unknown function. Previous cell culture studies using CLN3-overexpressing vectors and/or anti-CLN3 antibodies with questionable specificity have also localized CLN3 in cellular structures other than lysosomes. …”
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    Osmotic Stress Changes the Expression and Subcellular Localization of the Batten Disease Protein CLN3
  17. 1097
    “…Such findings would have implications for how cultural variations in symptom presentation are interpreted, and would also inform the cultural study of affective experiences more broadly. …”
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    Beyond “somatization” and “psychologization”: symptom-level variation in depressed Han Chinese and Euro-Canadian outpatients
  18. 1098
    “…On average, 24% of the instrument's items were considered relevant for measuring aspects of the hospital's caring culture. Studies showed moderate-to-high validity and reliability scores. …”
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    Measuring a caring culture in hospitals: a systematic review of instruments
  19. 1099
    “…In the present study we used the second generation MicroPlaSter ß® in analogy to the current clinical standard (2 min treatment time) in order to determine molecular changes induced by CAP using in vitro cell culture studies with human fibroblasts and an in vivo mouse skin wound healing model. …”
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    Cold Atmospheric Plasma (CAP) Changes Gene Expression of Key Molecules of the Wound Healing Machinery and Improves Wound Healing In Vitro and In Vivo
  20. 1100
    “…Our data show that metformin acts synergistically with FuOx to (a) induce cell death in chemo resistant (CR) HT-29 and HCT-116 colon cancer cells, (b) inhibit colonospheres formation and (c) enhance colonospheres disintegration. In vitro cell culture studies have further demonstrated that the combinatorial treatment inhibits migration of CR colon cancer cells. …”
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    Metformin: A Potential Therapeutic Agent for Recurrent Colon Cancer
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