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  1. 26401
    “…BACKGROUND: Alzheimer’s Disease (AD) is a progressive neurological disorder with no specific curative medications. While only a few medications are approved by FDA (i.e., donepezil, galantamine, rivastigmine, and memantine) to relieve symptoms (e.g., cognitive decline), sophisticated clinical skills are crucial to optimize the appropriate regimens given the multiple coexisting comorbidities in this patient population. …”
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    Using Artificial Intelligence to Learn Optimal Regimen Plan for Alzheimer’s Disease
  2. 26402
    “…BACKGROUND: Treatment of nonmetastatic esophageal cancer with curative intention remains a major challenge. Neoadjuvant radiochemotherapy followed by surgery, as described in the CROSS trial in 2012, has been established as a standard of care. …”
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    Reproducibility of the CROSS Trial Results in the Multimodal Treatment of Esophageal Cancer in Daily Practice: A Single Center Retrospective Observational Study
  3. 26403
    “…Breeders, collection curators, and other germplasm users require genetic information, both genome-wide and locus-specific, to effectively manage their genetically diverse plant material. …”
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    Deducing genotypes for loci of interest from SNP array data via haplotype sharing, demonstrated for apple and cherry
  4. 26404
    “…Multivariate Cox regression analysis showed that T stage (T3/T4), N stage (N2/N3), curative effect (progressive diseases) and high TXN expression were associated with poor survival, although high TXN expression was poorly predictive of overall survival. …”
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    Identification of thioredoxin-1 as a biomarker of lung cancer and evaluation of its prognostic value based on bioinformatics analysis
  5. 26405
    “…The samples were sequenced by next-generation sequencing (NGS), and the taxonomy was identified by resorting to Kraken2 and improved with Bracken, using a curated database called ‘GutHealth_DB’. The α and β-diversity analyses were used to determine the richness and evenness of the gut microbiota. …”
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    Breast Cancer Survivors and Healthy Women: Could Gut Microbiota Make a Difference?—“BiotaCancerSurvivors”: A Case-Control Study
  6. 26406
    “…ABSTRACT: The current study aims to profile sarcopenic condition (both at baseline and developed during treatment) in oropharyngeal carcinoma (OPC) patients treated with curative radiotherapy (RT) +/− chemotherapy and to evaluate its impact on oncological outcomes and toxicity. …”
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    Prognostic Impact of Sarcopenia’s Occurrence during Radiotherapy in Oropharyngeal Cancer Patients
  7. 26407
    “…SIMPLE SUMMARY: Neuroendocrine tumor (NET) patients often suffer from metastases, thereby eliminating surgery as a curative treatment option. A possible treatment strategy for these patients is peptide receptor radionuclide therapy (PRRT). …”
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    In Vivo Efficacy Testing of Peptide Receptor Radionuclide Therapy Radiosensitization Using Olaparib
  8. 26408
    “…METHODS AND MATERIALS: We identified patients with the 4 most common cancer types treated with curative-intent EBRT. Beam-on time for each fraction was extracted from the treatment planning system and averaged over each site and treatment modality. …”
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    Estimating Carbon Dioxide Emissions and Direct Power Consumption of Linear Accelerator–Based External Beam Radiation Therapy
  9. 26409
    “…Colorectal cancer was the most common metachronous tumor, diagnosed in 20 patients (51%), and diagnosed prior to PC or BTC in all cases. Curative surgery was attempted on 17 of 39 patients. …”
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    Clinical characteristics of pancreatic and biliary tract cancers in Lynch syndrome: A retrospective analysis from the Finnish National Lynch Syndrome Research Registry
  10. 26410
    “…CONCLUSION: Kyphoplasty for patients with osteoporotic thoracolumbar compression fractures complicated with diabetes can achieve a satisfactory clinical effect, the curative effect is affected by many factors, attention to these factors can improve the clinical effect.…”
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    Clinical effect of kyphoplasty in the treatment of osteoporotic thoracolumbar compression fractures in patients with diabetes
  11. 26411
    “…We have exhaustively curated the public data for AChE inhibition data and developed machine learning classification models for seven different species. …”
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    Validation of Acetylcholinesterase Inhibition Machine Learning Models for Multiple Species
  12. 26412
    “…In the isolates with IC(50) of 24 nM, regimen-I is recommended. Curative treatment criteria for mefloquine and artesunate were C(336h) (>408 ng.mL(-1)) or C(max)/IC(50) (>130.1 g.m/M), and C(max)/IC(50) (>381.2 g.m/M), respectively. …”
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    Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
  13. 26413
    “…The two currently available treatments, nintedanib and pirfenidone, are only able to slow down the disease without being curative. We demonstrated in the past that HSPB5, a low molecular weight heat shock protein, was involved in the development of fibrosis and therefore was a potential therapeutic target. …”
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    HSPB5 Inhibition by NCI-41356 Reduces Experimental Lung Fibrosis by Blocking TGF-β1 Signaling
  14. 26414
    “…CLINICAL DISCUSSION: Curative surgery is recommended for resectable liver metastases of colorectal cancer (CRLM), be it synchronous or heterochronous. …”
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    Pathological complete response of multiple liver metastases from colon cancer successfully treated with conversion surgery: A case report
  15. 26415
    “…Subgroup analysis indicated that exosome type and ED model type made no difference to curative effects. CONCLUSION: This meta-analysis suggests the therapeutic efficacy of stem cell–derived exosomes for ED. …”
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    Effects of stem cell–derived exosome therapy on erectile dysfunction: a systematic review and meta-analysis of preclinical studies
  16. 26416
    “…These disease features were then used to generate a phenotype risk score for tic disorder, which was applied across an independent set of 90,051 individuals. A previously curated set of tic disorder cases from an electronic health record algorithm followed by clinician chart review was used to validate the tic disorder phenotype risk score. …”
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    Developing a Phenotype Risk Score for Tic Disorders in a Large, Clinical Biobank
  17. 26417
    “…CPIC assigned a level to each gene-drug pair based on curated genotype-to-phenotype evidence. We analyzed a subgroup of 45 cases, inclusive of response type (ADRs/ineffectiveness). …”
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    The pharmacogenetics of CYP2D6 and CYP2C19 in a case series of antidepressant responses
  18. 26418
    “…Data were collected on comorbidities, cancer type and stage, performance status, ICI cycles, biomarkers, prior curative treatment, diagnostic evaluation, antibiotics, steroids, progression, and survival. …”
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    A Novel Workflow to Create a Checkpoint Inhibitor Pneumonitis Patient Registry
  19. 26419
    “…IMPACT AND IMPLICATIONS: Understanding factors counteracting HDV infections is paramount to develop curative therapies. We compared the responsiveness of three different cloned HDV strains to pegylated interferon alpha in chronically infected mice. …”
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    Strain-specific responsiveness of hepatitis D virus to interferon-alpha treatment
  20. 26420
    “…[Figure: see text] The use of curated feature sets did not demonstrate any statistically significant improvement over the complete genetic variation feature set. …”
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    290. Prediction of Severe Clostridioides difficile Infection Using Isolate Genomic Variation Influenced by Patient Comorbidity Score
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