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  1. 26621
    “…BACKGROUND: Patients with cancer of the lung or oesophagus, undergoing curative treatment, usually require a thoracotomy and a complex oncological resection. …”
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    Preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus (PRE-HIIT): protocol for a randomized controlled trial
  2. 26622
    “…Our findings indicate that inhibition of 5-Lox may emerge as a promising new approach to effectively kill ERPC cells sparing normal cells and suggest that development of a long-term curative therapy of prostate cancer may be possible by killing and eliminating ERPC cells with suitable 5-Lox-inhibitors.…”
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    Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis
  3. 26623
    “…This resource allows unprecedented insights into the past demography of SARS-CoV-2 but also monitoring of how the virus is adapting to its novel human host, providing information to direct drug and vaccine design. We curated a dataset of 7666 public genome assemblies and analysed the emergence of genomic diversity over time. …”
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    Emergence of genomic diversity and recurrent mutations in SARS-CoV-2
  4. 26624
    “…Mean age was 65.6 years, the most common cancer diagnoses were digestive organs (22.7%), male genital organs (20.5%) or breast (25.0%), 75.0% had metastatic or locally advanced cancer, 59.1% were treated with non-curative intention and 93.1% had Karnofsky Performance Status ≥ 80%. …”
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    Fully Integrated Oncology and Palliative Care Services at a Local Hospital in Mid-Norway: Development and Operation of an Innovative Care Delivery Model
  5. 26625
    “…Hematopoietic stem cell transplantation (HSCT) was applied as the major curative treatment in 25 (51%) of the patients, 18 patients survived transplantation, while two patients died and three required a second transplant in order to achieve full remission. …”
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    Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review
  6. 26626
    “…Therefore, if not accompanied with appropriate economic and epidemiological considerations, we anticipate that these measures might result in unprecedented difficulties among vulnerable segments of society to access essential services, including antiretroviral and prophylactic drugs among people living with HIV and Acquired Immune Deficiency Syndrome, anti-tuberculosis drugs, and curative and preventive treatments for malaria among pregnant women and children. …”
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    What does the COVID-19 pandemic mean for HIV, tuberculosis, and malaria control?
  7. 26627
    “…Several trials are exploring the curative potential of CAR T cells in other malignancies, and recent data on multiple myeloma and chronic lymphocytic leukemia are encouraging. …”
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    The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research Into Clinical Practice
  8. 26628
    “…Beneficial scores for decision making of curative surgeries were evaluated for each modality. …”
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    Computed tomography colonography versus colonoscopy for detection of colorectal cancer: a diagnostic performance study
  9. 26629
    “…METHODS: We retrospectively assessed 375 patients who were pathologically diagnosed with gastric cancer and underwent curative surgical resection at Tokyo Medical University, Japan, between September 2013 and October 2019. …”
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    Postoperative outcomes of gastric carcinoma with lymphoid stroma
  10. 26630
    “…Using automated delineation of the skeletal muscle, we have investigated the prognostic value of sarcopenia in locally advanced oesophageal cancer (LAOC) patients treated by curative-intent chemo-radiotherapy. METHODS: The clinical, nutritional, anthropometric, and functional-imaging ((18)FDG-PET/CT) data were collected in 97 patients treated between 2006 and 2012 in our institution. …”
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    Prognostic value of sarcopenia in patients treated by Radiochemotherapy for locally advanced oesophageal cancer
  11. 26631
    “…Although usage of embeddings is well described in the bioinformatics literature, the potential of end-to-end learning for single amino acids, as compared to more classical manually-curated encoding strategies, has not been systematically addressed. …”
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    Amino acid encoding for deep learning applications
  12. 26632
    “…While surgery is the only curative treatment option in early tumors, for locally advanced and metastatic patients further therapeutic targets are needed. …”
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    Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas
  13. 26633
    “…METHODS: In this study, we present a comprehensive IAV-host protein-protein interaction network that is obtained based on the literature-curated protein interaction datasets and some important interaction databases. …”
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    A systems biology-driven approach to construct a comprehensive protein interaction network of influenza A virus with its host
  14. 26634
    “…CONCLUSION: Because end-of-life care is more aggressive in HM patients compared to ST patients, a proactive integrated care approach with early start of palliative care alongside curative care is warranted. Timely discussions with patients and family about advance care planning and end-of-life choices can avoid inappropriate care at the end of life.…”
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    End-of-Life Trajectories of Patients With Hematological Malignancies and Patients With Advanced Solid Tumors Visiting the Emergency Department: The Need for a Proactive Integrated Care Approach
  15. 26635
    “…CONCLUSION: It is important to be cognizant of the initiation of caries in children through the initial stages so that efforts can be pooled in towards prevention rather than extensive curative measures. CLINICAL SIGNIFICANCE: In routine clinical examinations, WSLs are seldom detected. …”
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    Cross-sectional Study on White Spot Lesions and its Association with Dental Caries Experience among School Children
  16. 26636
    “…Mean differences between caregivers of curatively or palliatively treated patients were nonsignificant (p = 0.959) at T1. …”
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    Validation of a German version of the Caregiver Quality of Life Index-Cancer (CQOLC) in a sample of significant others of breast and gynaecologic cancer patients
  17. 26637
    “…DESIGN: Retrospective observational study. We curated data from the electronic health record, and used multivariable logistic regression to examine the association of pre-existing traits with a Covid-19 illness severity defined by level of required care: need for hospital admission, need for intensive care, and need for intubation. …”
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    Pre-existing traits associated with Covid-19 illness severity
  18. 26638
    “…BACKGROUND: Hematopoietic cell transplantation (HCT) is a curative option for a growing number of patients with hematologic diseases and malignancies. …”
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    Technology-enabled activation of skin cancer screening for hematopoietic cell transplantation survivors and their primary care providers (TEACH)
  19. 26639
    “…RESULTS: In total, 130 patients who underwent curative intent resection of pT4 colon cancer were included. …”
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    Subclassification of Multivisceral Resections for T4b Colon Cancer with Relevance for Postoperative Complications and Oncological Risks
  20. 26640
    “…Methods: A total of 1,046 gastric cancer patients who underwent curative gastrectomy in West China Hospital of Sichuan University from January 2011 to December 2016 were analyzed retrospectively. …”
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    Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer
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