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26661por Martin Saborido, Carlos, Borobia, Alberto M, Cobas, Javier, D'Antiga, Lorenzo, Frauca, Esteban, Hernández-Oliveros, Francisco, Jara, Paloma, López-Granados, Eduardo, Muñoz, Jose María, Nicastro, Emanuele, Ojeda, Jose Jonay, Pérez-Martínez, Antonio, Torres, Juan Manuel, Carcas, Antonio“…INTRODUCTION: Paediatric transplantation is the only curative therapeutic procedure for several end-stage rare diseases affecting different organs and body systems, causing altogether great impact in European children’s health and quality of life. …”
Publicado 2020
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26662por Swanson, Megan, Nakalembe, Miriam, Chen, Lee-may, Ueda, Stefanie, Namugga, Jane, Nakisige, Carol, Huchko, Megan J“…OBJECTIVES: This study aimed to report the proportion of women with a new diagnosis of cervical cancer recommended for curative hysterectomy as well as associated factors. …”
Publicado 2020
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26663por Hu, Huabin, Wu, Zehua, Wang, Chao, Huang, Yan, Zhang, Jianwei, Cai, Yue, Xie, Xiaoyu, Li, Jianxia, Shen, Cailu, Li, Weiwei, Ling, Jiayu, Xu, Xuehu, Deng, Yanhong“…METHODS: This retrospective study identified a cohort of patients with high-risk stage II and III dMMR CC who underwent curative surgery between May 2011 and July 2019. DFS was compared using the Kaplan-Meier survival methods and Cox proportional hazards models. …”
Publicado 2020
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26664por Mertens, Alexander C., Kalff, Marianne C., Eshuis, Wietse J., Van Gulik, Thomas M., Van Berge Henegouwen, Mark I., Gisbertz, Suzanne S.“…Patients who underwent esophagectomy with curative intent and gastric tube reconstruction for mid/distal esophageal or esophagogastric junction carcinoma (cT1-4aN0-3M0) from 2011 to 2016 were included. …”
Publicado 2020
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26665por Nagano, Hideki, Togawa, Tamotsu, Watanabe, Takeshi, Ohnishi, Kenji, Kimura, Toshihisa, Iida, Atsushi, Noriki, Sakon, Imamura, Yoshiaki, Sato, Yasunori, Goi, Takanori“…CONCLUSION: This is the first English case report of HO in a metachronous metastatic lymph node after the curative resection of HO-negative rectal cancer. Unlike HO lesions in past reports, the HO lesion did not show peripheral osteoblast-like cells, and the immunohistochemical findings indicated that the present case resulted from the EMT.…”
Publicado 2021
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26666por Dalle, Jean-Hugues, Balduzzi, Adriana, Bader, Peter, Pieczonka, Anna, Yaniv, Isaac, Lankester, Arjan, Bierings, Marc, Yesilipek, Akif, Sedlacek, Petr, Ifversen, Marianne, Svec, Peter, Toporski, Jacek, Gungor, Taifun, Wachowiak, Jacek, Glogova, Evgenia, Poetschger, Ulrike, Peters, Christina“…Allogeneic HSCT represents the only potentially curative treatment for very high risk (VHR) ALL. Two consecutive international prospective studies, ALL-SCT-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with VHR disease leading to any kind of HSCT. …”
Publicado 2020
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26667“…Rane’s test was also used to evaluate the curative potential of the n-butanol fraction that showed the highest effect during the 4-day suppressive test. …”
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26668por Xiao, Qiao, Yi, Xiaoping, Guan, Xiao, Yin, Hongling, Wang, Cikui, Zhang, Liang, Pang, Yingxian, Li, Minghao, Gong, Guanghui, Chen, Danlei, Liu, Longfei“…METHODS: The study consisted of 753 ccRCC patients treated with curative surgery between 2010 and 2018 at Xiangya Hospital Central South University (Changsha, China). …”
Publicado 2020
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26669“…However, the standard of care remains cytarabine and anthracyclines, and the primary hindrance towards curative treatment is the frequent emergence of intrinsic and acquired anticancer drug resistance. …”
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26670por Di Mauro, Vittoria, Ceriotti, Paola, Lodola, Francesco, Salvarani, Nicolò, Modica, Jessica, Bang, Marie-Louise, Mazzanti, Andrea, Napolitano, Carlo, Priori, Silvia G., Catalucci, Daniele“…This situation highlights the urgent need to overcome current difficulties by developing novel groundbreaking curative strategies. BrS has been associated with mutations in 18 different genes of which loss-of-function (LoF) CACNA1C mutations constitute the second most common cause. …”
Publicado 2021
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26671por Johnson, W. Evan, Odom, Aubrey, Cintron, Chelsie, Muthaiah, Mutharaj, Knudsen, Selby, Joseph, Noyal, Babu, Senbagavalli, Lakshminarayanan, Subitha, Jenkins, David F., Zhao, Yue, Nankya, Ethel, Horsburgh, C. Robert, Roy, Gautam, Ellner, Jerrold, Sarkar, Sonali, Salgame, Padmini, Hochberg, Natasha S.“…We developed a computational profiling platform of TB signature gene sets and characterized the diagnostic ability of existing signature gene sets to differentiate active TB from LTBI in the setting of malnutrition. METHODS: We curated 45 existing TB-related signature gene sets and developed our TBSignatureProfiler software toolkit that estimates gene set activity using multiple enrichment methods and allows visualization of single- and multi-pathway results. …”
Publicado 2021
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26672por Liang, Chengyuan, Hui, Nan, Liu, Yuzhi, Qiao, Guaiping, Li, Juan, Tian, Lei, Ju, Xingke, Jia, Minyi, Liu, Hong, Cao, Wenqiang, Yu, Pengcheng, Li, Han, Ren, Xiaodong“…However, there is still a lack of drugs with clear curative effects, and the clinical trial research of vaccines has not been completely finished. …”
Publicado 2021
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26673por Asahi, Yoh, Kamiyama, Toshiya, Orimo, Tatsuya, Shimada, Shingo, Nagatsu, Akihisa, Sakamoto, Yuzuru, Ishizuka, Chihiro, Hamada, Kazuya, Kamachi, Hirofumi, Takakuwa, Emi, Mitsuhashi, Tomoko, Taketomi, Akinobu“…Laparoscopic hepatectomy for the present 2 cases of HAML seemed to be effective for providing a correct diagnosis after the curative removement of liver tumor with a smaller invasion compared to open hepatectomy, and for denying risk of dissemination of the malignant tumor by needle biopsy that had to be considered before ruling out malignant tumor.…”
Publicado 2021
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26674por Roelands, Jessica, Mall, Raghvendra, Almeer, Hossam, Thomas, Remy, Mohamed, Mahmoud G., Bedri, Shahinaz, Al-Bader, Salha Bujassoum, Junejo, Kulsoom, Ziv, Elad, Sayaman, Rosalyn W., Kuppen, Peter J. K., Bedognetti, Davide, Hendrickx, Wouter, Decock, Julie“…We applied a unique approach that combines the use of curated survival data from The Cancer Genome Atlas (TCGA) Pan-Cancer clinical data resource, improved single-nucleotide polymorphism-based inferred ancestry assignment, and a novel breast cancer subtype classification to interrogate the TCGA and a local Arab breast cancer dataset. …”
Publicado 2021
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26675por Chen, Emerson Y., Mayo, Skye C., Sutton, Thomas, Kearney, Matthew R., Kardosh, Adel, Vaccaro, Gina M., Billingsley, Kevin G., Lopez, Charles D.“…PURPOSE: Resection of liver-only colorectal liver metastases (CRLM) with perioperative chemotherapy is potentially curative. Specific primary tumor and liver metastasis characteristics have been validated to estimate the risk of recurrence. …”
Publicado 2020
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26676por Seely, Dugald, Legacy, Mark, Auer, Rebecca C., Fazekas, Anna, Delic, Edita, Anstee, Caitlin, Angka, Leonard, Kennedy, Michael A., Tai, Lee-Hwa, Zhang, Tinghua, Maziak, Donna E., Shamji, Farid M., Sundaresan, R. Sudhir, Gilbert, Sebastien, Villeneuve, P. James, Ashrafi, Ahmad S., Inculet, Richard, Yasufuku, Kazuhiro, Waddell, Thomas K., Finley, Christian, Shargall, Yaron, Plourde, Madelaine, Fergusson, Dean A., Ramsay, Tim, Seely, Andrew J.E.“…BACKGROUND: Despite curative intent resection in patients with non-small cell lung cancer (NSCLC), recurrence leading to mortality remains too common. …”
Publicado 2021
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26677“…Our approach uses a database of 521,824 universal marker genes from 241 conserved gene families, which we curated from 3713 fungal, protist, non-vertebrate metazoan, and non-streptophyte archaeplastida genomes and transcriptomes. …”
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26678por McEntire, Caleb R. S., Song, Kun-Wei, McInnis, Robert P., Rhee, John Y., Young, Michael, Williams, Erika, Wibecan, Leah L., Nolan, Neal, Nagy, Amanda M., Gluckstein, Jeffrey, Mukerji, Shibani S., Mateen, Farrah J.“…Some of the diseases have curative treatments available while in other cases, supportive care remains the only management option. …”
Publicado 2021
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26679por Alsager, Mohammed, Neong, Shuet Fong, Gandhi, Radhika, Teriaky, Anouar, Tang, Ephraim, Skaro, Anton, Qumosani, Karim, Lilly, Les, Galvin, Zita, Selzner, Nazia, Bhat, Mamatha Pallavi, Puka, Klajdi, Brahmania, Mayur“…BACKGROUND: Liver transplantation (LT) remains the curative treatment for symptomatic Polycystic Liver Disease (PCLD) patients and is associated with excellent survival rates. …”
Publicado 2021
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26680por Bencomo-Alvarez, Alfonso E., Rubio, Andres J., Olivas, Idaly M., Gonzalez, Mayra A., Ellwood, Rebecca, Fiol, Carme Ripoll, Eide, Christopher A., Lara, Joshua J., Barreto-Vargas, Christian, Jave-Suarez, Luis F., Nteliopoulos, Georgios, Reid, Alistair G., Milojkovic, Dragana, Druker, Brian J., Apperley, Jane, Khorashad, Jamshid S., Eiring, Anna M.“…Despite success, targeting leukemic stem cells and overcoming drug resistance remain challenges for curative cancer therapy. To identify drivers of kinase-independent TKI resistance in CML, we performed genome-wide expression analyses on TKI-resistant versus sensitive CML cell lines, revealing a nuclear factor-kappa B (NF-κB) expression signature. …”
Publicado 2021
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