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26681por Brethon, Benoît, Lainey, Elodie, Caye-Eude, Aurélie, Grain, Audrey, Fenneteau, Odile, Yakouben, Karima, Roupret-Serzec, Julie, Le Mouel, Lou, Cavé, Hélène, Baruchel, André“…The good MRD response on the two clones made it possible to continue the curative intent with a hematopoietic stem cell transplant at 9 months of age. …”
Publicado 2021
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26682por Jia, Ru, Liu, Ningning, Cai, Guoxiang, Zhang, Yun, Xiao, Haijuan, Zhou, Lihong, Ji, Qing, Zhao, Ling, Zeng, Puhua, Liu, Huaimin, Huo, Jiege, Yue, Xiaoqiang, Zhang, Yi, Wu, Chaojun, Sun, Xiaoting, Feng, Yuanyuan, Liu, Hongjie, Liu, Hui, Han, Zhifen, Lai, Youying, Zhang, Yanbo, Han, Gang, Gong, Hangjun, Wang, Yan, Li, Qi“…METHODS: In this parallel-group study, patients who had undergone curative resection for stage III colon cancer were randomly assigned to receive adjuvant chemotherapy (FOLFOX q2w for 6 months, or CapeOx q3w for 6 months) plus PRM1201 (chemo+PRM1201 group) or adjuvant chemotherapy plus placebo (chemo+placebo group). …”
Publicado 2021
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26683por Zhao, Yiqing, Fu, Sunyang, Bielinski, Suzette J, Decker, Paul A, Chamberlain, Alanna M, Roger, Veronique L, Liu, Hongfang, Larson, Nicholas B“…METHODS: The algorithm was trained and validated using an existing epidemiology cohort consisting of 4914 patients with atrial fibrillation (AF) with manually curated incident stroke events. Various combinations of feature sets and machine learning classifiers were compared. …”
Publicado 2021
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26684por Shiraishi, Takuya, Ikeda, Koji, Tsukada, Yuichiro, Nishizawa, Yuji, Sasaki, Takeshi, Ito, Masaaki, Kojima, Motohiro, Ishii, Genichiro, Tsumura, Ryo, Saijou, Sinji, Koga, Yoshikatsu, Yasunaga, Masahiro, Matsumura, Yasuhiro“…METHODS: A total of 157 patients (86 men and 71 women; median age 63.0 years) with stage III CRC who underwent curative surgery were analyzed for TMEM180 expression as a retrospective cohort design. …”
Publicado 2021
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26685por Lewin, Jörn, Kottwitz, Denise, Aoyama, Johanna, deVos, Theo, Garces, Jorge, Hasinger, Oliver, Kasielke, Stefanie, Knaust, Florian, Rathi, Preeti, Rausch, Sebastian, Weiss, Gunter, Zipprich, Alexander, Mena, Edward, Fong, Tse-Ling“…HCC screening is recommended among individuals with cirrhosis using biannual abdominal ultrasound, for earlier tumor detection, administration of curative treatment, and improved survival. Surveillance by imaging with or without biomarkers such as alpha-fetoprotein (AFP) remains suboptimal for early stage HCC detection. …”
Publicado 2021
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26686por Shah, Shailja, Padhani, Zahra Ali, Als, Daina, Munyuzangabo, Mariella, Gaffey, Michelle F, Ahmed, Wardah, Siddiqui, Fahad J, Meteke, Sarah, Kamali, Mahdis, Jain, Reena P, Radhakrishnan, Amruta, Ataullahjan, Anushka, Das, Jai K, Bhutta, Zulfiqar A“…Moreover, there is very little information on coverage or effectiveness of nutrition interventions; more rigorous evaluation of effectiveness and delivery approaches is needed, including outside of camps and for preventive as well as curative nutrition interventions. PROSPERO REGISTRATION NUMBER: CRD42019125221.…”
Publicado 2021
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26687por Jiao, Haiyan, Yang, Hongjun, Yan, Zhiyi, Chen, Jianbei, Xu, Mengbai, Jiang, Youming, Liu, Yueyun, Xue, Zhe, Ma, Qingyu, Li, Xiaojuan, Chen, Jiaxu“…Xiaoyaosan and fluoxetine had obvious curative effects that could significantly alleviate the above changes in the hippocampus. …”
Publicado 2021
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26688por Paku, Masakatsu, Uemura, Mamoru, Kitakaze, Masatoshi, Fujino, Shiki, Ogino, Takayuki, Miyoshi, Norikatsu, Takahashi, Hidekazu, Yamamoto, Hirofumi, Mizushima, Tsunekazu, Doki, Yuichiro, Eguchi, Hidetoshi“…BACKGROUND: Local recurrence is common after curative resections for rectal cancer. Surgical intervention is among the best treatment choices. …”
Publicado 2021
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26689“…BACKGROUND: The Integrated Management of Newborn and Childhood Illness (IMNCI) strategy includes both preventive and curative interventions to improve practices in health facilities, the health system and at home. …”
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26690“…Five HCP Community managers (CMs) were trained in on-line platform curation, moderation and screening. An on-line survey was designed to capture data from HPiR members. …”
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26691por Cos, Heidy, Li, Dingwen, Williams, Gregory, Chininis, Jeffrey, Dai, Ruixuan, Zhang, Jingwen, Srivastava, Rohit, Raper, Lacey, Sanford, Dominic, Hawkins, William, Lu, Chenyang, Hammill, Chet W“…BACKGROUND: Pancreatic cancer is the third leading cause of cancer-related deaths, and although pancreatectomy is currently the only curative treatment, it is associated with significant morbidity. …”
Publicado 2021
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26692por de’Angelis, Nicola, Espin, Eloy, Ris, Frederic, Landi, Filippo, Le Roy, Bertrand, Coccolini, Federico, Celentano, Valerio, Gurrado, Angela, Pezet, Denis, Bianchi, Giorgio, Memeo, Riccardo, Vitali, Giulio C., Solis, Alejandro, Denet, Christine, Di Saverio, Salomone, de’Angelis, Gian Luigi, Kraft, Miquel, Gonzálvez-Guardiola, Paula, Stakelum, Aine, Catena, Fausto, Fuks, David, Winter, Des C., Testini, Mario, Martínez-Pérez, Aleix“…For the present analysis, SFC patients were selected if they had received emergency surgical resection with curative intent between 2000 and 2018. Extended right colectomy (ERC), left colectomy (LC), and segmental left colectomy (SLC) were evaluated and compared. …”
Publicado 2021
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26693por Li, Bin, Zhao, Guihu, Zhou, Qiao, Xie, Yali, Wang, Zheng, Fang, Zhenghuan, Lu, Bin, Qin, Lixia, Zhao, Yuwen, Zhang, Rui, Jiang, Li, Pan, Hongxu, He, Yan, Wang, Xiaomeng, Luo, Tengfei, Zhang, Yi, Wang, Yijing, Chen, Qian, Liu, Zhenhua, Guo, Jifeng, Tang, Beisha, Li, Jinchen“…By systematic review and curation of multiple lines of public studies, we integrate multiple layers of genetic data (rare variants and copy-number variants identified from patients with PD, associated variants identified from genome-wide association studies, differentially expressed genes, and differential DNA methylation genes) and age at onset in PD. …”
Publicado 2021
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26694por Fan, Yanfen, Yu, Yixing, Wang, Ximing, Hu, Mengjie, Du, Mingzhan, Guo, Lingchuan, Sun, Shifang, Hu, Chunhong“…METHODS: Eighty-one patients with VETC-negative HCC and 52 patients with VETC-positive HCC who underwent Gd-EOB-DTPA-enhanced MRI before curative partial hepatectomy were retrospectively evaluated in our institution. …”
Publicado 2021
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26695por Abrahamsson, Hanna, Meltzer, Sebastian, Hagen, Vidar Nyløkken, Johansen, Christin, Bousquet, Paula A., Redalen, Kathrine Røe, Ree, Anne Hansen“…BACKGROUND: We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating levels of 25-hydroxyvitamin D [25(OH) D] were low. …”
Publicado 2021
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26696por Krüger, William H., Hirt, Carsten, Basara, Nadezda, Sayer, Herbert G., Behre, Gerhard, Fischer, Thomas, Grobe, Norbert, Maschmeyer, Georg, Neumann, Thomas, Schneidewind, Laila, Niederwieser, Dietger, Dölken, Gottfried, Schmidt, Christian A.“…The early mortality is higher than after autoSCT; however, the survival curves after alloSCT indicate the curative potential of this therapy. AlloSCT is a standard of care for all feasible patients with refractory or relapsed MCL and should offer to selected patients with de novo MCL and a poor risk profile. …”
Publicado 2021
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26697por Kim, Ji-Yeon, Lee, Yong Seok, Yu, Jonghan, Park, Youngmin, Lee, Se Kyung, Lee, Minyoung, Lee, Jeong Eon, Kim, Seok Won, Nam, Seok Jin, Park, Yeon Hee, Ahn, Jin Seok, Kang, Mira, Im, Young-Hyuck“…Several prognosis prediction models have been developed for breast cancer (BC) patients with curative surgery, but there is still an unmet need to precisely determine BC prognosis for individual BC patients in real time. …”
Publicado 2021
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26698por Cui, Qingya, Qian, Chongsheng, Xu, Nan, Kang, Liqing, Dai, Haiping, Cui, Wei, Song, Baoquan, Yin, Jia, Li, Zheng, Zhu, Xiaming, Qu, Changju, Liu, Tianhui, Shen, Wenhong, Zhu, Mingqing, Yu, Lei, Wu, Depei, Tang, Xiaowen“…Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for acute myeloid leukemia (AML). …”
Publicado 2021
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26699por Holländer-Mieritz, Cecilie, Vogelius, Ivan R, Kristensen, Claus A, Green, Allan, Rindum, Judith L, Pappot, Helle“…Patients aged ≥18 years intended for primary or postoperative curatively intended RT for HNC will be recruited. Consenting patients will be asked to wear an Apple Watch on the wrist during and until 2 weeks after RT. …”
Publicado 2021
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26700por Delaidelli, Alberto, Richner, Mette, Jiang, Lixiang, van der Laan, Amelia, Bergholdt Jul Christiansen, Ida, Ferreira, Nelson, Nyengaard, Jens R., Vægter, Christian B., Jensen, Poul H., Mackenzie, Ian R., Sorensen, Poul H., Jan, Asad“…Using immunohistochemical analyses, we show a robust nuclear NRF2 accumulation in post-mortem PD midbrain, detected by NRF2 phosphorylation on the serine residue 40 (nuclear active p-NRF2, S40). Curated gene expression analyses of four independent publicly available microarray datasets revealed considerable alterations in NRF2-responsive genes in the disease affected regions in PD, including substantia nigra, dorsal motor nucleus of vagus, locus coeruleus and globus pallidus. …”
Publicado 2021
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