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  1. 27241
    “…Fewer than 30% of patients with hepatocellular carcinoma (HCC) are eligible to receive curative therapies, and so a better understanding of the molecular mechanisms of HCC is needed to identify potential therapeutic targets. …”
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    miR‐204‐5p suppresses hepatocellular cancer proliferation by regulating homeoprotein SIX1 expression
  2. 27242
    “…Formalin-fixed paraffin-embedded lesion samples of the patients with curatively resected CRC were collected. Next-generation sequencing was performed to identify somatic gene mutations. …”
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    PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients
  3. 27243
    “…BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated in lung fibroblasts and alveolar type II cells (ATII), thereby contributing to lung fibrosis in IPF. …”
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    The JAK2 pathway is activated in idiopathic pulmonary fibrosis
  4. 27244
    por Geisler, Christoph
    Publicado 2018
    “…CONCLUSIONS: Our results demonstrate TBLASTN searching massively parallel sequencing (MPS) assemblies with a compact, manually curated viral protein database is more sensitive for adventitious virus detection than BLASTN, as we identified various sequences that encoded virus-like proteins, but had no similarity to viral sequences at the nucleotide level. …”
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    A new approach for detecting adventitious viruses shows Sf-rhabdovirus-negative Sf-RVN cells are suitable for safe biologicals production
  5. 27245
    “…Furthermore, SCCmecFinder will be curated and updated as new elements are found and it is easy to use and freely accessible.…”
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    SCCmecFinder, a Web-Based Tool for Typing of Staphylococcal Cassette Chromosome mec in Staphylococcus aureus Using Whole-Genome Sequence Data
  6. 27246
    “…Although recent applications of genomic copy number and sequencing analyses revealed various ring chromosome structures from an increasing number of case studies, there was no organized effort for compilating and curating cytogenomic and clinical finding for ring chromosomes. …”
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    Human ring chromosome registry for cases in the Chinese population: re-emphasizing Cytogenomic and clinical heterogeneity and reviewing diagnostic and treatment strategies
  7. 27247
    “…CONCLUSIONS: A comprehensive resource of accurately annotated and curated Triticeae MPK and MKK sequences has been created for wheat, barley, rye, triticale, and two ancestral wheat species, goat grass and red wild einkorn. …”
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    Analysis of MAPK and MAPKK gene families in wheat and related Triticeae species
  8. 27248
    “…These datasets have undergone extensive curation using an automated workflow to select only high-quality data, and the chemical structures were standardized prior to calculation of the molecular descriptors. …”
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    OPERA models for predicting physicochemical properties and environmental fate endpoints
  9. 27249
    “…METHODS: We retrospectively conducted cohort study to evaluate the PNI as a predictor of survival in 368 resectable gastric cancer patients who underwent potentially curative gastrectomy at our institute between January 2010 and December 2016. …”
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    Prognostic nutritional index as a predictor of survival in resectable gastric cancer patients with normal preoperative serum carcinoembryonic antigen levels: a propensity score matching analysis
  10. 27250
    “…Synonym expansion approaches apply thesauri, ontologies, and query logs. All need laborious curation and maintenance. Furthermore, access to query logs is in general restricted. …”
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    LAILAPS-QSM: A RESTful API and JAVA library for semantic query suggestions
  11. 27251
    “…METHODS: We assessed the expression of PD-L1 and HIF-1α by immunohistochemistry in tumor tissue from 90 HCC patients who underwent curative hepatectomy. The results were validated in an independent cohort of additional 90 HCC patients. …”
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    Association of PD-L1 and HIF-1α Coexpression with Poor Prognosis in Hepatocellular Carcinoma
  12. 27252
    “…The audience for these standards includes researchers, journals, and granting agencies, and also the developers and curators of databases that may contribute to video data sharing efforts. …”
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    Data Management Rubric for Video Data in Organismal Biology
  13. 27253
    “…Patients ≥ 75 years undergoing radiotherapy with a curative intent for localized prostate cancer with or without androgen deprivation therapy (ADL) were eligible for study inclusion. …”
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    Comprehensive Geriatric Assessment and quality of life after localized prostate cancer radiotherapy in elderly patients
  14. 27254
    “…Shuxuening injection (SXNI) is a widely prescribed herbal medicine of Ginkgo biloba extract (EGB) for cerebral and cardiovascular diseases in China. However, its curative effects on ischemic stroke and heart diseases and the underlying mechanisms remain unknown. …”
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    Tnfrsf12a-Mediated Atherosclerosis Signaling and Inflammatory Response as a Common Protection Mechanism of Shuxuening Injection Against Both Myocardial and Cerebral Ischemia-Reperfusion Injuries
  15. 27255
    por Mondal, Shinjini, Van Belle, Sara
    Publicado 2018
    “…Inspired by an SDG vision, tackling NCDs will require a comprehensive approach rooted in preventive, curative and rehabilitative services. In India, some early momentum in this respect can already be witnessed, certainly in addressing the first two challenges identified by Buse and Hawkes, leadership and intersectoral coherence, and a shift from treatment to prevention. …”
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    India’s NCD strategy in the SDG era: are there early signs of a paradigm shift?
  16. 27256
    “…RESULTS: Here, we used a functional comparative annotation strategy combining orthology data, mining of curated genomics as well as protein domain databases and phylogenetic reconstructions. …”
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    Genome-wide expert annotation of the epigenetic machinery of the plant-parasitic nematodes Meloidogyne spp., with a focus on the asexually reproducing species
  17. 27257
    “…Furthermore, the serum VEGF levels could be used to assess prognosis and curative effects.…”
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    Serum VEGF levels in the early diagnosis and severity assessment of non-small cell lung cancer
  18. 27258
    “…Methods: The different seed gene lists associated with the herbs of LXNX formula, the CHD co-morbid diseases and symptoms which were relieved by the LXNX formula (co-morbid diseases and symptoms) were curated manually from biomedical databases and published biomedical literatures. …”
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    Prediction of Molecular Mechanisms for LianXia NingXin Formula: A Network Pharmacology Study
  19. 27259
    “…Inclusion criteria included complete (R0) and curative surgery cases, intra-thoracic esophageal cancer, preoperative biopsy-proven squamous cell carcinoma, and cases without LN metastasis (WL, cN0 and pN0) or with unsuspected LN metastasis (UL, cN0 and pN1). …”
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    Validity of upfront surgery for patients with unsuspected lymph node metastasis in esophageal cancer: a propensity scoring matching study
  20. 27260
    “…BACKGROUND: Few studies have shown nomograms that may predict disease-specific survival (DSS) probability after curative D2 gastrectomy for advanced gastric cancer (AGC), particularly among Chinese patients. …”
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    A novel nomogram individually predicting disease-specific survival after D2 gastrectomy for advanced gastric cancer
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