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27261por Blatt, Katharina, Menzl, Ingeborg, Eisenwort, Gregor, Cerny-Reiterer, Sabine, Herrmann, Harald, Herndlhofer, Susanne, Stefanzl, Gabriele, Sadovnik, Irina, Berger, Daniela, Keller, Alexandra, Hauswirth, Alexander, Hoermann, Gregor, Willmann, Michael, Rülicke, Thomas, Sill, Heinz, Sperr, Wolfgang R., Mannhalter, Christine, Melo, Junia V., Jäger, Ulrich, Sexl, Veronika, Valent, Peter“…Leukemic stem cells (LSCs) are an emerging target of curative anti-leukemia therapy. In acute lymphoblastic leukemia (ALL), LSCs frequently express CD34 and often lack CD38. …”
Publicado 2018
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27262por Paz, Alessandra, Rigoni, Lisandra, Fischer, Gustavo, Schittler, Monise, Pezzi, Annelise, Valim, Vanessa, Dahmer, Alice, Zambonato, Bruna, Amorin, Bruna, Sehn, Filipe, Silva, Maria Aparecida da, Daudt, Liane, Silla, Lucia“…BACKGROUND: Hematopoietic stem cell transplantation is a curative treatment for many patients with hematological disorders. …”
Publicado 2018
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27263por Fang, Li, Wu, Jining, Luo, Jing, Wen, Ping, Xiong, Mingxia, Cao, Jinlong, Chen, Xiaolan, Yang, Junwei“…The bone loss in SHPT had its predilection site in the load-bearing cancellous bone. After curative total PTX without autotransplantation, BMD improved significantly in both lumbar spine and hip overall. …”
Publicado 2018
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27264por Ausmees, Kristiina, John, Aji, Toor, Salman Z., Hellander, Andreas, Nettelblad, Carl“…For scientific questions where curated called variants are not sufficient, the sheer size of the datasets makes analysis prohibitively expensive. …”
Publicado 2018
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27265“…In addition, whether in the literature curation or clinical validation, Regorafenib has a strong correlation with breast cancer. …”
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27266por Cusin, Isabelle, Teixeira, Daniel, Zahn-Zabal, Monique, Rech de Laval, Valentine, Gleizes, Anne, Viassolo, Valeria, Chappuis, Pierre O., Hutter, Pierre, Bairoch, Amos, Gaudet, Pascale“…RESULTS AND CONCLUSION: We have collected, curated, and structured the molecular and cellular phenotypic impact of 3654 distinct BRCA1 variants. …”
Publicado 2018
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27267por Lim, Jeong Uk, Yeo, Chang Dong, Kang, Hye Seon, Park, Chan Kwon, Kim, Ju Sang, Kim, Jin Woo, Kim, Seung Joon, Lee, Sang Haak“…While previous study on COP-LMR has evaluated its prognostic value in NSCLC patients who underwent curative resections, the combination of these two markers has not been evaluated in advanced NSCLC yet. …”
Publicado 2018
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27268por Romano, Kara D., Hill, Colin, Trifiletti, Daniel M., Peach, M. Sean, Horton, Bethany J., Shah, Neil, Campbell, Dylan, Libby, Bruce, Showalter, Timothy N.“…BACKGROUND: Brachytherapy (BT) is a vital component of the curative treatment of locally advanced cervical cancer. …”
Publicado 2018
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27269por Drury, Josephine A., Parkin, Kirstin L., Coyne, Lucy, Giuliani, Emma, Fazleabas, Asgerally T., Hapangama, Dharani K.“…METHODS: Eutopic and ectopic endometrial samples from 82 women across the menstrual cycle with/without endometriosis and from 8 baboons before and after induction of endometriosis were examined for CD56 and NKp30 expression with immunohistochemistry, quantified using computer assisted image analysis. Curated secretory phase endometrial microarray datasets were interrogated for NK cell receptors and their ligands. …”
Publicado 2018
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27270por Dijkstra, B. M., Motekallemi, A., den Dunnen, W. F. A., Jeltema, J. R., van Dam, G. M., Kruyt, F. A. E., Groen, R. J. M.“…Surgical removal can only be curative by complete resection; however surgical access can be challenging due to anatomical localization and local invasion of bone and soft tissues. …”
Publicado 2018
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27271por Pannier, Diane, Adenis, Antoine, Bogart, Emilie, Dansin, Eric, Clisant-Delaine, Stéphanie, Decoupigny, Emilie, Lesoin, Anne, Amela, Eric, Ducornet, Sandrine, Meurant, Jean-Pierre, Le Deley, Marie-Cécile, Penel, Nicolas“…METHODS: Patients ≥ 18 years of age with refractory metastatic cancers were eligible if no standard curative measures existed. Paclitaxel was administered IV weekly (D1, D8, D15; D1 = D28) in combination with a fixed dose of OMC (50 mg twice a day). …”
Publicado 2018
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27272“…The radioactive iodine curative ratio in younger patients is also lower than that in the other two groups (37.35, 18.75, and 32.08%, separately, P=0.029). …”
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27273por Abusahmin, Hussam, Surya, Ashutosh, Aldridge, Andrew, Okosieme, Onyebuchi, Das, Gautam“…OBJECTIVE: Parathyroidectomy is usually curative in primary hyperparathyroidism (PHPT), but its utility would be limited if patients are elderly who may either refuse surgery or may have advanced frailty and multimorbidity. …”
Publicado 2018
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27274por Chen, Xu, Wu, Lei, Li, Dezhi, Xu, Yanmei, Zhang, Luping, Niu, Kai, Kong, Rui, Gu, Jiaoyang, Xu, Zihan, Chen, Zhengtang, Sun, Jianguo“…However, radioresistance generally occurs in the majority of these patients, leading to poor curative effect, and the underlying mechanism remains unclear. …”
Publicado 2018
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27275“…BACKGROUND: Core collections provide genebank curators and plant breeders a way to reduce size of their collections and populations, while minimizing impact on genetic diversity and allele frequency. …”
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27276por Topaz, Nadav, Boxrud, Dave, Retchless, Adam C., Nichols, Megan, Chang, How-Yi, Hu, Fang, Wang, Xin“…BMScan employs species-specific thresholds for previously-validated, genome-wide similarity statistics compiled from a curated reference genome collection to rapidly and accurately identify the species of uncharacterized bacterial meningitis pathogens and closely related pathogens. …”
Publicado 2018
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27277“…However, none of these therapies have been shown to be curative and are associated with frequent relapses. …”
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27278por Kavian, Niloufar, Mehlal, Souad, Jeljeli, Mohamed, Saidu, Nathaniel Edward Bennett, Nicco, Carole, Cerles, Olivier, Chouzenoux, Sandrine, Cauvet, Anne, Camus, Claire, Ait-Djoudi, Mehdi, Chéreau, Christiane, Kerdine-Römer, Saadia, Allanore, Yannick, Batteux, Frederic“…In this work, we investigated whether NRF2 could be implicated in the pathogenesis of SSc, and if this pathway could represent a new therapeutic target in this orphan disease with no curative medicine. Skin biopsies from 11 patients and 10 controls were harvested, and skin fibroblasts were extracted. …”
Publicado 2018
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27279por Willett, Duwayne L., Kannan, Vaishnavi, Chu, Ling, Buchanan, Joel R., Velasco, Ferdinand T., Clark, John D., Fish, Jason S., Ortuzar, Adolfo R., Youngblood, Josh E., Bhat, Deepa G., Basit, Mujeeb A.“…Conclusion SNOMED CT-based diagnosis value sets are simple to develop, concise, understandable to clinicians, useful in the EHR and for analytics, and shareable. Developing curated SNOMED CT hierarchy-based condition definitions for public use could accelerate cross-organizational population health efforts, “smarter” EHR feature configuration, and clinical–translational research employing EHR-derived data.…”
Publicado 2018
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27280por Ostaszewski, Marek, Kieffer, Emmanuel, Danoy, Grégoire, Schneider, Reinhard, Bouvry, Pascal“…RESULTS: We investigate knowledge discovery in manually curated and annotated molecular interaction diagrams. …”
Publicado 2018
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