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28261por Liu, Chengyou, Hogan, Andrew M., Sturm, Hunter, Khan, Mohd Wasif, Islam, Md. Mohaiminul, Rahman, A. S. M. Zisanur, Davis, Rebecca, Cardona, Silvia T., Hu, Pingzhao“…Lastly, we applied the trained model to an externally curated drug set that had experimental results against M. tuberculosis genes to examine the effectiveness of our method. …”
Publicado 2022
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28262por Batch, Karen E., Yue, Jianwei, Darcovich, Alex, Lupton, Kaelan, Liu, Corinne C., Woodlock, David P., El Amine, Mohammad Ali K., Causa-Andrieu, Pamela I., Gazit, Lior, Nguyen, Gary H., Zulkernine, Farhana, Do, Richard K. G., Simpson, Amber L.“…To develop the models, a subset of the reports was curated for ground-truth: 7,732 total reports in the lung metastases dataset from 867 individual patients; 2,777 reports in the liver metastases dataset from 315 patients; and 4,107 reports in the adrenal metastases dataset from 404 patients. …”
Publicado 2022
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28263por Peng, Panxin, Luan, Yusong, Sun, Peng, Wang, Liming, Zeng, Xufeng, Wang, Yangyang, Cai, Xuhao, Ren, Peide, Yu, Yonggang, Liu, Qi, Ma, Haoyue, Chang, Huijing, Song, Bolun, Fan, Xiaohua, Chen, Yinggang“…Metastasectomy is the most common curative method. However, evidence of the factors affecting the prognosis of CRC patients after resection of LM and/or PM is still insufficient. …”
Publicado 2022
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28264por Leister, Iris, Mittermayr, Rainer, Mattiassich, Georg, Aigner, Ludwig, Haider, Thomas, Machegger, Lukas, Kindermann, Harald, Grazer-Horacek, Anja, Holfeld, Johannes, Schaden, Wolfgang“…Despite extensive efforts in the treatment of SCI, there is yet no causal, curative treatment approach available. Extracorporeal shock wave therapy (ESWT) has been successfully implemented in clinical use. …”
Publicado 2022
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28265por Li, Wei, Li, Tiandong, Sun, Chenguang, Du, Yimeng, Chen, Linna, Du, Chunyan, Shi, Jianxiang, Wang, Weijie“…Surgical resection is the only “curative” treatment. However, only a minority of patients with PC can obtain surgery. …”
Publicado 2022
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28266por Al-Zubaidi, Mohammed, Viswambaram, Pravin, McCombie, Steve, Liow, Elizabeth, Lenzo, Nat, Ferguson, Tom, Redfern, Andrew D, Gauci, Richard, Hayne, Dickon“…This trial will also examine the safety and utility of (89)Zr-TLX250-PET/CT in patients either undergoing preoperative staging of bladder or other urothelial carcinomas for curative intent, or with known metastatic urothelial carcinomas. …”
Publicado 2022
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28267por Hyldgaard, Charlotte, Trolle, Christian, Harders, Stefan Markus Walbom, Engberg, Henriette, Rasmussen, Torben Riis, Møller, Henrik“…METHODS: The referral and imaging pathways for all patients diagnosed with lung cancer in 2013–2018 were described based on manually curated information from the electronic health care systems and staging information from the Danish Lung Cancer Registry. …”
Publicado 2022
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28268por Mengist Dessie, Anteneh, Fenta Feleke, Sefineh, Getaye Workie, Sewnet, Getinet Abebe, Tiruayehu, Mossu Chanie, Yonas, Kassa Yalew, Anteneh“…Hence, preventive and curative health services should be provided for these schoolchildren to achieve a considerable reduction in the prevalence of skin disorders.…”
Publicado 2022
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28269por Wu, Zehua, Hu, Huabin, Wang, Chao, Zhang, Jianwei, Cai, Yue, Xie, Xiaoyu, Huang, Yan, Deng, Yanhong“…METHODS: A total of 854 consecutive patients with locally advanced rectal cancer with MMR status who underwent neoadjuvant therapy followed by curative surgery between January 2013 and December 2018 were included this retrospective study. …”
Publicado 2022
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28270por Bäuerle, Alexander, Martus, Peter, Erim, Yesim, Schug, Caterina, Heinen, Jana, Krakowczyk, Julia Barbara, Steinbach, Jasmin, Damerau, Mirjam, Bethge, Wolfgang, Dinkel, Andreas, Dries, Sebastian, Mehnert-Theuerkauf, Anja, Neumann, Anja, Schadendorf, Dirk, Tewes, Mitra, Wiltink, Jörg, Wünsch, Alexander, Zipfel, Stephan, Graf, Johanna, Teufel, Martin“…We will include patients who have received a cancer diagnosis in the past 12 months, are in a curative treatment setting, are 18–65 years old, have given informed consent and experience high perceived psychological distress (Hospital Anxiety and Depression Scale ≥13) for at least 1 week. …”
Publicado 2022
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28271por Schleberger, Ruben, Riess, Jan, Brauer, Anika, Pinnschmidt, Hans O., Rottner, Laura, Moser, Fabian, Moser, Julia, Kany, Shinwan, My, Ilaria, Lemoine, Marc D., Reissmann, Bruno, Meyer, Christian, Metzner, Andreas, Ouyang, Feifan, Kirchhof, Paulus, Rillig, Andreas“…INTRODUCTION: Catheter ablation of ventricular arrhythmias emerging from the ventricular outflow tracts and adjacent structures is very effective and considered almost curative in patients without structural heart disease (SHD). …”
Publicado 2022
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28272por Zhou, Yadi, Liu, Yuan, Gupta, Shagun, Paramo, Mauricio I., Hou, Yuan, Mao, Chengsheng, Luo, Yuan, Judd, Julius, Wierbowski, Shayne, Bertolotti, Marta, Nerkar, Mriganka, Jehi, Lara, Drayman, Nir, Nicolaescu, Vlad, Gula, Haley, Tay, Savaş, Randall, Glenn, Lis, John T., Feschotte, Cédric, Erzurum, Serpil C., Cheng, Feixiong, Yu, Haiyuan“…Leveraging our interactome, we performed network-based drug screens for over 2,900 FDA-approved/investigational drugs and obtained a curated list of 23 drugs that had significant network proximities to SARS-CoV-2 host factors, one of which, carvedilol, showed promising antiviral properties. …”
Publicado 2022
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28273por Araújo, Leonardo Pereira de, Dias, Maria Eduarda Carvalho, Scodeler, Gislaine Cristina, Santos, Ana de Souza, Soares, Letícia Martins, Corsetti, Patrícia Paiva, Padovan, Ana Carolina Barbosa, Silveira, Nelson José de Freitas, de Almeida, Leonardo Augusto“…To select an epitope with the highest probability of binding to the MHC or BCR, all epitopes of each consensus sequence were aligned. The curation indicated 1, 4, 8, and 21 selected epitopes for E, M, N, and S proteins, respectively. …”
Publicado 2022
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28274por Kantor, Daniel, Farlow, Martin, Ludolph, Albert, Montaner, Joan, Sankar, Raman, Sawyer Jr, Robert N, Stocchi, Fabrizio, Lara, Agnès, Clark, Sarah, Deschet, Karine, Ouyahia, Loucif, Hadjiat, Yacine“…METHODS: Specific scientific criteria were designed using a 5-point scale to measure the quality of curated and original content published on the website: for Summaries, (1) source reliability and topic relevance for neurologists, (2) structure, and (3) scientific and didactic value; for Congress highlights, (1) relevance of congress selection, (2) congress coverage based on the original program, and (3) scientific and didactic value of individual abstracts; for Expert points of view and talks, (1) credibility (authorship) and topic relevance for neurologists, (2) scientific and didactic value, and (3) reliability (references) and format. …”
Publicado 2022
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28275“…BACKGROUND: The overall survival for patients with resectable PDAC following curative surgical resection hasn’t been improved significantly, as a considerable proportion of patients develop recurrence within a year. …”
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28276por Dong, Zhongyi, Ni, Bo, Yang, Linxi, Guan, Yujing, Zhu, Chunchao, Zhao, Enhao, Zhao, Gang, Xia, Xiang, Zhang, Zizhen“…Gastrectomy with radical lymph node dissection is the cornerstone of curative treatment for Stage III gastric cancer, and postoperative systemic chemotherapy with docetaxel, S-1 improved patients’ disease-free survival rates. …”
Publicado 2022
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28277por Sawong, Suphunwadee, Pekthong, Dumrongsak, Suknoppakit, Pennapha, Winitchaikul, Thanwarat, Kaewkong, Worasak, Somran, Julintorn, Intapa, Chaidan, Parhira, Supawadee, Srisawang, Piyarat“…The therapeutic applications lowered TNF-α, IL-6, TGF-β, and α-SMA inflammatory cytokines in a similar way, implying that CGDCM had a curative effect against the inflammation-induced liver carcinogenesis produced by DEN exposure. …”
Publicado 2022
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28278por Dordoni, Paola, Remmers, Sebastiaan, Valdagni, Riccardo, Bellardita, Lara, De Luca, Letizia, Badenchini, Fabio, Marenghi, Cristina, Roobol, Monique J., Venderbos, Lionne D. F.“…Trial registration This study is registered in the Dutch Trial Registry (www.trialregister.nl) under NL1622 (registration date 11-03-2009), ‘PRIAS: Prostate cancer Research International: Active Surveillance—guideline and study for the expectant management of localized prostate cancer with curative intent’.…”
Publicado 2022
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28279“…DED seriously affects the quality of life of patients; however, the current curative effect of medicine for moderate to severe DED is poor. …”
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28280por Aboelella, Nada S, Brandle, Caitlin, Okoko, Ogacheko, Gazi, Md Yeashin, Ding, Zhi-Chun, Xu, Hongyan, Gorman, Gregory, Bollag, Roni, Davila, Marco L, Bryan, Locke J, Munn, David H, Piazza, Gary A, Zhou, Gang“…There is increasing need to improve the efficacy of ACT so that durable, curative outcomes can be achieved in a broad patient population. …”
Publicado 2022
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