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  1. 28461
    “…In patients with resectable tumors, surgery followed by adjuvant chemotherapy is the only curative treatment. However, the 5-year survival is 20%. …”
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    A 25-gene classifier predicts overall survival in resectable pancreatic cancer
  2. 28462
    “…In addition, compounds 3d, 3f, 3i and 3m showed better curative activities against tobacco mosaic virus (TMV), with EC(50) values of 152.8, 99.7, 127.1, and 167.3 μg/mL, respectively, which were better than that of ningnanmycin (211.1 μg/mL). …”
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    Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold
  3. 28463
    por Huang, Zixia, Teeling, Emma C.
    Publicado 2017
    “…Current 3′-UTR mining tools, such as GETUTR, 3USS and UTRscan, all depend on a well-annotated reference genome or curated 3′-UTR sequences, which hinders their application on a myriad of non-model organisms where the genomes are not available. …”
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    ExUTR: a novel pipeline for large-scale prediction of 3′-UTR sequences from NGS data
  4. 28464
    “…However, the concomitant induction of immunosuppressive pathways suggests that a combination with immunotherapy could further enhance the in situ vaccination ability of radiotherapy, possibly further improving the curative potential of SBRT in this subset of patients.…”
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    Local High-Dose Radiotherapy Induces Systemic Immunomodulating Effects of Potential Therapeutic Relevance in Oligometastatic Breast Cancer
  5. 28465
    “…Consistent with these curated networks, mRNA expression of DICER1, AGO1, CREB1, DAPK1, and TP53 was downregulated significantly with miR-103a-3p expression in FDRs. …”
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    Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects
  6. 28466
    “…BACKGROUND: Jia-Wei-Jiao-Tai-Wan (JWJTW), composed of Jiao-Tai-Wan (Cinnamomum cassia and Rhizoma coptidis) and other antidiabetic herbs, including Astragalus membranaceus, Herba Gynostemmatis, Radix Puerariae Lobatae, Folium Mori and Semen Trigonellae, is widely used to treat diabetes and has demonstrated a curative effect in the clinic, but the potential mechanism is unknown. …”
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    Jia-Wei-Jiao-Tai-Wan ameliorates type 2 diabetes by improving β cell function and reducing insulin resistance in diabetic rats
  7. 28467
    “…PATIENTS AND METHODS: Pretreatment biopsy samples and data from the blood tests of 92 patients with rectal cancer who underwent curative resection after nCRT were retrospectively obtained. …”
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    Density of CD8+ lymphocytes in biopsy samples combined with the circulating lymphocyte ratio predicts pathologic complete response to chemoradiotherapy for rectal cancer
  8. 28468
    “…METHODS: Thirty patients with RPS treated with curative intent between 2006 and 2015 were included in this retrospective study. …”
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    Intensity modulated radiation therapy and surgery for Management of Retroperitoneal Sarcomas: a single-institution experience
  9. 28469
    “…Among children, LT can be curative for unresectable HCC confined to the liver and without vascular invasion, incidental HCC, embryonal tumors, and metastatic neuroendocrine tumors. …”
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    Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single‐center experience (1981‐2015)
  10. 28470
    “…METHODS: Seventeen patients with cervical carcinoma FIGO stage IB2–IIIB were treated with curative intent between 2011 and 2015. A total dose of 50.4 Gy was prescribed to the elective pelvic nodal volume. …”
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    Highly conformal combined radiotherapy with cisplatin and gemcitabine for treatment of loco-regionally advanced cervical cancer – a retrospective study
  11. 28471
    “…Patients undergoing curative surgery (n = 16) were enrolled and their laboratory and clinical history data collected. …”
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    DNA Methylation and Hydroxymethylation in Primary Colon Cancer and Synchronous Hepatic Metastasis
  12. 28472
    “…Furthermore, we have applied TCOA to two bimolecular expert-curate networks. Source code for our TCOA is freely available from http://sysbio.sibcb.ac.cn/cb/chenlab/software.htm or https://github.com/WilfongGuo/guoweifeng. …”
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    A novel algorithm for finding optimal driver nodes to target control complex networks and its applications for drug targets identification
  13. 28473
    “…RESULTS: Here, we present two new computational methods that utilize all the PubMed articles as domain specific background knowledge to assist in the extraction and curation of gene-mutation-drug relations from the literature. …”
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    Deep learning of mutation-gene-drug relations from the literature
  14. 28474
    “…Firstly, high-quality IHD-associated genes from both human curated disease-gene association database and biomedical literatures were integrated. …”
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    Integrated Modules Analysis to Explore the Molecular Mechanisms of Phlegm-Stasis Cementation Syndrome with Ischemic Heart Disease
  15. 28475
    por Gu, Xiang, Dong, Feilin, Gu, Jianhua
    Publicado 2018
    “…The purpose of this study was to investigate the curative effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). …”
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    Analysis of effect of 1α-hydroxyvitamin D3 on benign paroxysmal positional vertigo and risk factors
  16. 28476
    “…METHODS: This single-center retrospective observational study enrolled 433 STS patients who underwent surgery with curative intent. An inverse probability of treatment-weighted (IPTW) analysis was implemented to account rigorously for imbalances in prognostic variables between the adjuvant treatment groups. …”
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    Benefit of Adjuvant Radiotherapy for Local Control, Distant Metastasis, and Survival Outcomes in Patients with Localized Soft Tissue Sarcoma: Comparative Effectiveness Analysis of an Observational Cohort Study
  17. 28477
    “…Systemic effect levels were curated from ToxRefDB, HESS-DB and COSMOS-DB from numerous study types totaling 4379 in vivo studies for 1247 chemicals. …”
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    Predicting in vivo effect levels for repeat-dose systemic toxicity using chemical, biological, kinetic and study covariates
  18. 28478
    “…In conclusion, we found that rhMFGE8 pretreatment effectively alleviated neurological deficits and decreased brain water content and apoptotic cells in the SBI model through the MFGE8/integrin-β3 pathway, and treatment time was an important factor in achieving curative effects. Therefore, MFGE8 pretreatment may serve as a promising therapeutic strategy for SBI patients.…”
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    Milk Fat Globule-Epidermal Growth Factor-8 Pretreatment Attenuates Apoptosis and Inflammation via the Integrin-β3 Pathway after Surgical Brain Injury in Rats
  19. 28479
    “…CONCLUSIONS: CCT exerts a curative effect on neuropsychiatric symptoms, but the evidence remains insufficient. …”
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    Does Chinese calligraphy therapy reduce neuropsychiatric symptoms: a systematic review and meta-analysis
  20. 28480
    “…Of 379 (78%) people treated with curative intent, most were receiving ongoing colorectal cancer follow up from multiple providers with 28% (23–32%) attending three or more different doctors. …”
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    Patterns of follow up and survivorship care for people with colorectal cancer in new South Wales, Australia: a population-based survey
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