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28701por Shishido, Stephanie N., Sayeed, Salmaan, Courcoubetis, George, Djaladat, Hooman, Miranda, Gus, Pienta, Kenneth J., Nieva, Jorge, Hansel, Donna E., Desai, Mihir, Gill, Inderbir S., Kuhn, Peter, Mason, Jeremy“…Cystectomy, alone or with other treatments, is used to treat most BCa patients, as it offers the best chance of cure. However, even with curative intent, 29% of patients experience relapse of the cancer, 50% of which occur within the first year of surgery. …”
Publicado 2022
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28702por Safi, Sami-Alexander, Haeberle, Lena, Goering, Wolfgang, Keitel, Verena, Fluegen, Georg, Stoecklein, Nikolas, Rehders, Alexander, Knoefel, Wolfram Trudo, Esposito, Irene“…Methods: Panel next generation sequencing (NGS) and immunohistochemistry (IHC) were performed on paraffin-embedded tumor tissues from curatively treated PDAC patients. Tumor slides were re-evaluated with a focus on the histomorphology. …”
Publicado 2022
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28703por Patil, Vishal S., Harish, Darasaguppe R., Vetrivel, Umashankar, Roy, Subarna, Deshpande, Sanjay H., Hegde, Harsha V.“…To start with, the phytochemical dataset of T. chebula was curated from biological databases and the published literature. …”
Publicado 2022
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28704“…BACKGROUND: There are no curative medical therapies for Crohn’s disease (CD). …”
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28705por Liu, Yujie, Liu, Qinwen, Yin, Chuanhui, Li, Yi, Wu, Jie, Chen, Quanlin, Yu, Hailang, Lu, Aiping, Guan, Daogang“…Currently, the prescription of herbal medicine and their derived proprietary Chinese medicines are playing increasingly important roles in the treatment of OP due to their significant curative effects and few side effects. Among these prescriptions, Gushukang Granules (GSK), Xianling Gubao Capsules (XLGB), and Er-xian Decoction (EXD) are widely employed at the clinic on therapy of OP, which also is in line with the compatibility principle of “different treatments for the same disease” in herbal medicine. …”
Publicado 2022
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28706por Stikbakke, Einar, Wilsgaard, Tom, Haugnes, Hege Sagstuen, Pedersen, Mona Irene, Knutsen, Tore, Støyten, Martin, Giovannucci, Edward, Eggen, Anne Elise, Thune, Inger, Richardsen, Elin“…Patients with available tissue samples after a prostatectomy with curative intent were identified (n = 189). The tissue expression of miR-24-1-5p in prostate cancer was examined by in situ hybridization (ISH) in tissue microarray (TMA) blocks by semi-quantitative scoring by two independent investigators. …”
Publicado 2022
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28707“…The observation group was additionally treated with singulair tablets and ketotifen tablets for 14 days. The curative effect were observed after treatment. The first second forced expiratory volume (FEV1), forced vital capacity (FVC) and FEV1 as percentage of predicted value (FEV1% pred), blood oxygen pressure (PaO(2)) and blood carbon dioxide pressure (PaCO(2)), high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT), Th17 and Treg levels were measured in both groups before and after treatment. …”
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28708por Daneels, Willem, Rosskamp, Michael, Macq, Gilles, Saadoon, Estabraq Ismael, De Geyndt, Anke, Offner, Fritz, Poirel, Hélène A.“…Our data show that the majority of older patients are still started on first-line regimens with curative intent and a substantial proportion of them benefit from this approach. …”
Publicado 2022
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28709“…The ROC curve was drawn to analyze the value of the three indicators in predicting the curative effect in children with ABURTI. Pearson test was used to analyze the correlation among the expression of HBP, PCT, and CRP. …”
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28710por Fisher, Katie, Wang, Xiao Qian, Lee, Ashley, Morcilla, Vincent, de Vries, Anneke, Lee, Eunok, Eden, John-Sebastian, Deeks, Steven G., Kelleher, Anthony D., Palmer, Sarah“…The PRLS assay provides a new level of sensitivity for understanding the genetic composition of plasma-derived HIV-1 RNA from viremic individuals either pretherapy or after treatment interruption, which will be invaluable in assessing possible HIV-1 curative strategies. IMPORTANCE We developed novel plasma-derived RNA using long-range sequencing assays (PRLS assay; 8.3 kb, gag-3′, and 5.0 kb, int-3′). …”
Publicado 2022
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28711por Lisjak, Michela, De Caneva, Alessia, Marais, Thibaut, Barbon, Elena, Biferi, Maria Grazia, Porro, Fabiola, Barzel, Adi, Zentilin, Lorena, Kay, Mark A., Mingozzi, Federico, Muro, Andrés F.“…Many inborn errors of metabolism require life-long treatments and, in severe conditions involving the liver, organ transplantation remains the only curative treatment. Non-integrative AAV-mediated gene therapy has shown efficacy in adult patients. …”
Publicado 2022
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28712por Yue, Yaoting, Li, Nan, Shahid, Husnain, Bi, Dongsheng, Liu, Xin, Song, Shaoli, Ta, Dean“…BACKGROUND: The accurate definition of gross tumor volume (GTV) of esophageal squamous cell carcinoma (ESCC) can promote precise irradiation field determination, and further achieve the radiotherapy curative effect. This retrospective study is intended to assess the applicability of leveraging deep learning-based method to automatically define the GTV from 3D (18)F-FDG PET/CT images of patients diagnosed with ESCC. …”
Publicado 2022
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28713por Sha, Xiaoyuan, Chan, Leung, Fan, Xiaoyi, Guo, Penghao, Chen, Tianfeng, Liu, Lian, Zhong, Jingxiang“…The eye surface retention time, ocular irritation, and curative effect of the NAT ophthalmic suspension and Gel@PLGA-PEI-PEG@NAT on a rabbit fungal keratitis model were evaluated. …”
Publicado 2022
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28714por Renzulli, Matteo, Mottola, Margherita, Coppola, Francesca, Cocozza, Maria Adriana, Malavasi, Silvia, Cattabriga, Arrigo, Vara, Giulio, Ravaioli, Matteo, Cescon, Matteo, Vasuri, Francesco, Golfieri, Rita, Bevilacqua, Alessandro“…SIMPLE SUMMARY: Microvascular invasion (MVI) is a universally recognised predictor of hepatocellular carcinoma (HCC) recurrence after curative treatments, whose diagnosis, nowadays, is still postponed to surgery, through histopathological specimen investigation. …”
Publicado 2022
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28715“…During the treatment, the vital signs, inflammatory response indexes, fluid balance, and nutrition were continuously monitored; the body position was changed every 2 hours; and the curative effect was evaluated one week after treatment. …”
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28716por Contreras Garcia, Maria, Walshe, Emily, Steketee, Pieter C., Paxton, Edith, Lopez-Vidal, Javier, Pearce, Michael C., Matthews, Keith R., Ezzahra-Akki, Fatima, Evans, Alec, Fairlie-Clark, Karen, Matthews, Jacqueline B., Grey, Finn, Morrison, Liam J.“…The 7SL sRNA signal was undetectable or significantly reduced by 96-h post treatment; at 1 × curative dose there was no detectable signal in 5/5 cattle infected with T. congolense, and in 3/5 cattle infected with T. vivax, with the signal being reduced 14,630-fold in the remaining two T. vivax cattle. …”
Publicado 2022
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28717por Klunder, Merel B., Bruggink, Janneke L. M., Huynh, Leon D. H., Bodewes, Frank A. J. A., van der Steeg, Alida F. W., Kraal, Kathelijne C. J. M., van de Ven, C. P. (Kees), van Grotel, Martine, Zsiros, József, Wijnen, Marc H. W. A., Molenaar, I. Q. (Quintus), Porte, Robert J., de Meijer, Vincent E., de Kleine, Ruben H.“…The majority of these tumours are hepatoblastoma (HB) and hepatocellular carcinoma (HCC), for which radical resection, often in combination with chemotherapy, is the only curative treatment option. We investigated the surgical outcome of children with a malignant liver tumour in a consecutive cohort in the Netherlands. …”
Publicado 2022
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28718por Zhao, Yue-Yang, Yang, Yu-Qi, Sheng, Hong-Hao, Tang, Qing, Han, Ling, Wang, Su-Mei, Wu, Wan-Yin“…Background: Fuzheng Kang’ai decoction (FZKA) has been widely used to treat Non-Small Cell Lung Cancer (NSCLC) patients in China for decades, showing definitively curative effects in clinic. Recently, we found that FZKA could induce NSCLC cell ferroptosis, another type of programmed cell death (PCD), which is totally different from cell apoptosis. …”
Publicado 2022
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28719por Seol, Donghyeok, Lim, Jin Soo, Sung, Samsun, Lee, Young Ho, Jeong, Misun, Cho, Seoae, Kwak, Woori, Kim, Heebal“…We collected 16S-ITS-23S rRNA operon sequences extracted from bacterial genomes from NCBI GenBank and performed curation. A total of 97,781 16S-ITS-23S rRNA operon sequences covering 9,485 species from 43,653 genomes were obtained. …”
Publicado 2022
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28720por Chen, Cheng, Jiang, JianTao, Fu, ShaoLing, Wang, Cheng, Su, Yan, Mei, GuoHua, Xue, JianFeng, Zou, Jian, Li, XueQian, Shi, ZhongMin“…CONCLUSIONS: The HyProCure procedure for pediatric flexible flatfoot achieved satisfactory curative effects with a low complication rate; implant depth was associated with unsatisfactory postoperative outcome.…”
Publicado 2022
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