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  1. 28821
    “…Therefore, this study aimed to generate and explore a high-quality bovine SV catalogue exploiting a unique cattle family cohort data (total 266 samples, forming 127 trios). RESULTS: We curated 13,731 SVs segregating in the population, consisting of 12,201 deletions, 1,509 duplications, and 21 multi-allelic CNVs (> 50-bp). …”
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    High-resolution structural variants catalogue in a large-scale whole genome sequenced bovine family cohort data
  2. 28822
    “…For this reason, there is great interested in the development of new therapies targeting KDM1A and KDM5B, particularly in the context of castrate resistant PCa (CRPC), where conventional androgen deprivation therapies and androgen receptor signalling inhibitors are no longer effective. As there is no curative therapy for CRPC, new approaches are urgently required to suppress androgen signalling that prevent, delay or reverse progression to the castrate resistant state. …”
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    The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer
  3. 28823
    por Amegbor, Prince M., Addae, Angelina
    Publicado 2023
    “…METHODS: The data from 195 countries were curated from the World Bank’s World Development Indicators (WDI) spanning from 2000 to 2017 and national estimates for under-five mortality from the UN Inter-agency Group for Child Mortality Estimation (UN IGME).We built parametric and non-parametric Bayesian space-time interaction models to examine the effect of development indicators on under-five mortality rates. …”
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    Spatiotemporal analysis of the effect of global development indicators on child mortality
  4. 28824
    “…CONCLUSION: While salvage surgery with FTF reconstruction is the primary curative option for patients with advanced recurrent OCSCC, the present findings may help guide discussions with patients who have advanced recurrent regional disease and high GGT preoperatively, especially if there is a small chance of reaching surgical radicality.…”
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    Predictors of survival in advanced oral cancers after salvage surgery with free tissue flap reconstruction
  5. 28825
    “…Patients who receive treatment with curative intent but are poor candidates for or decline surgery receive definitive bimodality therapy. …”
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    ‘CROSS’-ing into the ‘Real World’: a retrospective cohort study of patients receiving trimodality and bimodality therapy for esophageal cancer
  6. 28826
    “…Using this resource, we curated a functional, strain-resolved view on how Salmonella remodels intact murine gut communities, advancing pathobiome understanding beyond inferences from prior amplicon-based approaches. …”
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    Exposing new taxonomic variation with inflammation — a murine model-specific genome database for gut microbiome researchers
  7. 28827
    “…INTRODUCTION: The composite coverage index (CCI) is the weighted average coverage of eight preventive and curative interventions received along the maternal and childcare continuum. …”
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    Evaluation of maternal and child care continuum in Guinea: a secondary analysis of two demographic and health surveys using the composite coverage index (CCI)
  8. 28828
    “…After a median follow-up of 4.9 years, 5-year progression-free survival (PFS) and OS rates of 84 patients without TP63-R treated with curative-intent anthracycline-based chemotherapy were 41% and 53%, respectively. …”
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    ALK-negative anaplastic large cell lymphoma with DUSP22 rearrangement has distinctive disease characteristics with better progression-free survival: a LYSA study
  9. 28829
    “…In life-limiting conditions it is important that palliative support can be provided even when curative attempts are being utilised. In Papua New Guinea, as in other low- and middle-income countries there is a lack of services and training on PPC. …”
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    Children with palliative care needs in Papua New Guinea, and perspectives from their parents and health care workers: a qualitative study
  10. 28830
    “…Although many biological treatments provide some success in the initial clearance of lesions, there is a dispute about the long-term maintenance of the disease, as no current biological treatment has been shown to be curative. Topical therapies are still the most widely used agents as first-line and maintenance treatment for psoriasis. …”
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    Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial
  11. 28831
    “…Inclusion criteria were: ≥ 18 years old, intended curative chemoradiotherapy, investigation under anesthesia. …”
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    Lymphatic mapping for image-guided radiotherapy in patients with locally advanced uterine cervical cancer: a feasibility study
  12. 28832
    “…The primary outcome of this study is the proportion of patients with pT1 CC that is curatively treated with CAL-WR only and in whom thus organ-preservation could be achieved. …”
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    Limited wedge resection for T1 colon cancer (LIMERIC-II trial) – rationale and study protocol of a prospective multicenter clinical trial
  13. 28833
    “…Complete excision is curative, and the outcome is generally favorable; although transient deficits may be seen.…”
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    Cystic Cerebral Cavernous Malformations: Report of Five Cases and a Review of Literature
  14. 28834
    “…METHODS: We performed a retrospective review of a prospectively maintained database of patients who had undergone curative resection of pathological stage I–III primary lung adenocarcinoma from January 1995 to December 2012 followed by metastatic recurrence and resection of metastatic tumor (n=87). …”
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    Organ-specific heterogeneity in tumor-infiltrating immune cells and cancer antigen expression in primary and autologous metastatic lung adenocarcinoma
  15. 28835
    “…This study investigated this association in NSCLC patients considered for potentially curative treatment and explored whether the two methods provide independent prognostic information. …”
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    Associations between detectable circulating tumor DNA and tumor glucose uptake measured by (18)F-FDG PET/CT in early-stage non-small cell lung cancer
  16. 28836
    “…CONCLUSION: This study highlights the oncological safety of NAC for patients being treated with curative intent for LACC using RCT and propensity-matched studies only. …”
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    Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies
  17. 28837
    “…BACKGROUND AND OBJECTIVES: LAMA2-related muscular dystrophy (LAMA2-MD) is a rare neuromuscular disease characterized by proximal and axial muscle weakness, rigidity of the spine, scoliosis, and respiratory impairment. No curative treatment options exist, yet promising preclinical studies are ongoing. …”
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    LAMA2-Related Muscular Dystrophy Across the Life Span: A Cross-sectional Study
  18. 28838
    “…DESIGN, SETTING AND DATA: Using a retrospective cohort design, we curated a text corpus containing 382,666 clinical notes collected between 01/01/2017 through 12/31/2020 from primary care electronic medical records in Toronto Canada. …”
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    Quality indices for topic model selection and evaluation: a literature review and case study
  19. 28839
    “…PURPOSE: Current antiretroviral therapies (ART) for human immunodeficiency virus (HIV) are not curative, as the virus persists in latent reservoirs, requiring lifelong adherence to ART and increasing the risk of co-morbidities. …”
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    Nanodepots Encapsulating a Latency Reversing Agent and Broadly Neutralizing Antibody Enhance Natural Killer Cell Cytotoxicity Against an in vitro Model of Latent HIV
  20. 28840
    “…Stratified analysis showed that the target embolization might be beneficial for unruptured AVMs [HR, 0.42 (95% CI, 0.08–2.29)], while the curative embolization improved the outcome of ruptured AVMs [HR, 0.29 (95% CI, 0.10-0.87)]. …”
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    Association of embolization with long-term outcomes in brain arteriovenous malformations: a propensity score-matched analysis using nationwide multicenter prospective registry data
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