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  1. 28901
    “…Following NGS, human sequences are removed and remaining sequences are aligned to a curated pathogen database of >1,000 organisms. Organisms present above a statistical threshold are quantified in DNA molecules per microliter (MPM) and reported. …”
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    762. Integrating Diagnostics of Tomorrow into Clinical Practice Today: One Infectious Disease Group’s First 90 Days Experience with the Karius® Test
  2. 28902
    “…We find enrichment for DE of genes curated in the SFARI human gene database. Pathways showing evidence of enrichment included those related to immune cell signalling and immune response, transcriptional control and cell cycle/proliferation. …”
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    RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation
  3. 28903
    “…Further, candidate HLA ligands were manually curated. Peripheral blood mononuclear cells were stimulated in vitro with epitope candidate peptides, and functional T cell responses were assessed by intracellular cytokine staining. …”
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    A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer
  4. 28904
    por van Santen, Jeffrey A., Jacob, Grégoire, Singh, Amrit Leen, Aniebok, Victor, Balunas, Marcy J., Bunsko, Derek, Neto, Fausto Carnevale, Castaño-Espriu, Laia, Chang, Chen, Clark, Trevor N., Cleary Little, Jessica L., Delgadillo, David A., Dorrestein, Pieter C., Duncan, Katherine R., Egan, Joseph M., Galey, Melissa M., Haeckl, F.P. Jake, Hua, Alex, Hughes, Alison H., Iskakova, Dasha, Khadilkar, Aswad, Lee, Jung-Ho, Lee, Sanghoon, LeGrow, Nicole, Liu, Dennis Y., Macho, Jocelyn M., McCaughey, Catherine S., Medema, Marnix H., Neupane, Ram P., O’Donnell, Timothy J., Paula, Jasmine S., Sanchez, Laura M., Shaikh, Anam F., Soldatou, Sylvia, Terlouw, Barbara R., Tran, Tuan Anh, Valentine, Mercia, van der Hooft, Justin J. J., Vo, Duy A., Wang, Mingxun, Wilson, Darryl, Zink, Katherine E., Linington, Roger G.
    Publicado 2019
    “…Using a combination of manual curation and automated data mining approaches we have created a database of microbial natural products (The Natural Products Atlas, www.npatlas.org) that includes 24 594 compounds and contains referenced data for structure, compound names, source organisms, isolation references, total syntheses, and instances of structural reassignment. …”
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    The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery
  5. 28905
    “…BACKGROUND: Hematopoietic stem cell transplantation (HCT), also referred to as blood and marrow transplantation (BMT), is a high-risk, but potentially curative therapy for a number of cancer and noncancer conditions. …”
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    A Mobile Health App (Roadmap 2.0) for Patients Undergoing Hematopoietic Stem Cell Transplant: Qualitative Study on Family Caregivers' Perspectives and Design Considerations
  6. 28906
    “…Using the joint model, follow-up care of PDAC patients after curative therapy can be stratified.…”
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    CA19-9 for detecting recurrence of pancreatic cancer
  7. 28907
    “…OBJECTIVES AND ENDPOINTS OF THE PHASE II STUDY: Our main objective is to investigate the efficacy, in term of CRR (R0-R1), of treatment intensification in patients with liver-only CRLM not amenable to curative-intent resection (and/or ablation) after at least 2 months of induction sys-CT. …”
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    Treatment intensification with hepatic arterial infusion chemotherapy in patients with liver-only colorectal metastases still unresectable after systemic induction chemotherapy – a randomized phase II study -- SULTAN UCGI 30/PRODIGE 53 (NCT03164655)- study protocol
  8. 28908
    “…Since local recurrences are amenable to curative therapy, these mutations may inform the selection of subsequent endocrine therapies.…”
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    ESR1 mutations are frequent in newly diagnosed metastatic and loco-regional recurrence of endocrine-treated breast cancer and carry worse prognosis
  9. 28909
    “…Spinal muscular atrophy type 1 (SMA-1) is a severe neurodegenerative disorder, which in the absence of curative treatment, leads to death before 1 year of age in most cases. …”
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    Palliative Care in SMA Type 1: A Prospective Multicenter French Study Based on Parents' Reports
  10. 28910
    “…All patients with histologically confirmed HNSCC treated at a specialist cancer centre with curative-intent non-surgical treatment who underwent baseline and response assessment FDG PET-CT between August 2008 and May 2017 were included. …”
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    Post-treatment FDG PET-CT in head and neck carcinoma: comparative analysis of 4 qualitative interpretative criteria in a large patient cohort
  11. 28911
    por Befekadu, Ager, Yitayal, Mezgebu
    Publicado 2020
    “…BACKGROUND: The HEP was established decades ago to address preventive, promotive and selective curative services through Health Extension Workers (HEWs). …”
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    Knowledge and practice of health extension workers on drug provision for childhood illness in west Gojjam, Amhara, Northwest Ethiopia
  12. 28912
    “…Even after potentially curative resection the risk for tumor recurrence is high. …”
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    Relevance of suspicious lymph nodes in preoperative imaging for resectability, recurrence and survival of intrahepatic cholangiocarcinoma
  13. 28913
    “…The symptomatic treatments used in COVID-19 have frequent interactions with the most used psychotropics. If there is no curative treatment for infection to SARS-CoV-2, the interactions of the various molecules currently tested with several classes of psychotropic drugs (antidepressants, antipsychotics) are important to consider because of the risk of changes in cardiac conduction. …”
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    Informations relatives aux psychotropes et à leurs adaptations éventuelles pour les patients souffrant de troubles psychiques en France pendant l’épidémie à SARS-CoV-2
  14. 28914
    “…Methods: Patients with advanced PPGL who were heavily pre-treated and were ineligible for curative surgery or chemotherapy received a dosimetric dose followed by up to two therapeutic doses (each at 296 MBq/kg to a max of 18.5 GBq). …”
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    OR25-07 A Multi-Center, Open-Label, Pivotal Phase 2 Study of Azedra® (HSA I-131-MIBG) in Patients with Unresectable, Locally Advanced or Metastatic Pheochromocytoma or Paraganglioma: Updated Long-Term Survival and Safety
  15. 28915
    “…BACKGROUND: Assessment of the immune status of muscle-invasive bladder cancer (MIBC) has previously shown to be prognostically relevant after treatment with curative intent. We conducted this study to develop a clinically applicable immune gene expression assay to predict prognosis and adjuvant chemotherapy benefit. …”
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    Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy
  16. 28916
    “…The proposed guideline is believed to accommodate more patients receiving less invasive surgery without compromising the curative effect.…”
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    Surgical treatment strategies for extra-pelvic intravenous leiomyomatosis
  17. 28917
    “…The available literature indicates that telemedicine has been implemented successfully in several common clinical scenarios, including the decision-making process following a diagnosis of nonmetastatic PCa, follow-up care of patients with localized PCa after curative treatments, initial diagnosis of hematuria, management diagnosis and follow-up care of uncomplicated urinary stones and uncomplicated UTIs, and initial evaluation, behavioral therapies, and pelvic floor muscle training in UI patients, as well as follow-up care after surgical treatments of stress urinary incontinence or pelvic organ prolapse. …”
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    Telehealth in Urology: A Systematic Review of the Literature. How Much Can Telemedicine Be Useful During and After the COVID-19 Pandemic?
  18. 28918
    “…Results from two recent clinical studies in China suggest that traditional Chinese medicine (TCM) formula Dingkun pill (DKP) showed a curative effect by improving the clinical pregnancy rate in women with DOR and POR. …”
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    Efficacy and safety of Dingkun pill for female infertility patients with low prognosis undergoing in vitro fertilization-embryo transfer: study protocol for a multicenter, double-blind, randomized, placebo-controlled trial
  19. 28919
    “…METHODS: We retrospectively reviewed the pretreatment [(18)F]FDG PET/CT images of 75 MSGC patients treated with curative intent. Using a 1.5:1 ratio, the patients were randomly divided into a training and validation group. …”
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    Development and validation of a prognostic model incorporating [(18)F]FDG PET/CT radiomics for patients with minor salivary gland carcinoma
  20. 28920
    “…METHODS: In this phase I dose-expansion cohort, patients with advanced SCCHN not amenable to curative therapy that progressed/recurred after platinum therapy in the recurrent/metastatic setting, or <6 months after platinum therapy in the locally advanced setting, received bintrafusp alfa 1200 mg intravenously every 2 weeks. …”
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    Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort
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