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28981por Huang, Liang-Chin, Taujale, Rahil, Gravel, Nathan, Venkat, Aarya, Yeung, Wayland, Byrne, Dominic P., Eyers, Patrick A., Kannan, Natarajan“…We exploit KinOrtho here to identify kinase orthologs and show that its well-curated kinome ortholog set can serve as a valuable resource for illuminating understudied kinases, and the KinOrtho framework can be extended to any protein-family of interest. …”
Publicado 2021
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28982por Maoz, Asaf, Merenstein, Carter, Koga, Yusuke, Potter, Austin, Gower, Adam C, Liu, Gang, Zhang, Sherry, Liu, Hanqiao, Stevenson, Christopher, Spira, Avrum, Reid, Mary E, Campbell, Joshua D, Mazzilli, Sarah A, Lenburg, Marc E, Beane, Jennifer“…Using the biopsies and brushes, the ratio of private (ie, found in one patient only) and public (ie, found in two or more patients) TCRs was quantified, and the CDR3 sequences were compared with those found in curated databases with known antigen specificities. …”
Publicado 2021
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28983por Arikawa, Koji, Ide, Keigo, Kogawa, Masato, Saeki, Tatsuya, Yoda, Takuya, Endoh, Taruho, Matsuhashi, Ayumi, Takeyama, Haruko, Hosokawa, Masahito“…Despite improvements in bioinformatic approaches to generate curated metagenome-assembled genomes (MAGs), existing metagenome binners obtain population consensus genomes but they are nowhere comparable to genomes sequenced from isolates in terms of strain level resolution. …”
Publicado 2021
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28984por Zhao, Dantong, Zhou, Zhongliang, Shen, Chi, Ibrahim, Sahardid, Zhao, Yaxin, Cao, Dan, Lai, Sha“…Humanistic care, preventive care and curative treatment strategies focusing on such populations should be developed and refined. …”
Publicado 2021
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28985por Teepe, Gisbert W, Da Fonseca, Ashish, Kleim, Birgit, Jacobson, Nicholas C, Salamanca Sanabria, Alicia, Tudor Car, Lorainne, Fleisch, Elgar, Kowatsch, Tobias“…METHODS: We systematically searched for apps addressing depression in the Apple App Store and Google Play Store, as well as in curated lists from the Anxiety and Depression Association of America, the United Kingdom National Health Service, and the American Psychological Association in August 2020. …”
Publicado 2021
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28986“…Oligometastatic disease (OMD) is an intermediate state between widespread metastases and locally confined disease, where curative strategies may be effective for some patients. …”
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28987por De La Vega, Francisco M., Chowdhury, Shimul, Moore, Barry, Frise, Erwin, McCarthy, Jeanette, Hernandez, Edgar Javier, Wong, Terence, James, Kiely, Guidugli, Lucia, Agrawal, Pankaj B., Genetti, Casie A., Brownstein, Catherine A., Beggs, Alan H., Löscher, Britt-Sabina, Franke, Andre, Boone, Braden, Levy, Shawn E., Õunap, Katrin, Pajusalu, Sander, Huentelman, Matt, Ramsey, Keri, Naymik, Marcus, Narayanan, Vinodh, Veeraraghavan, Narayanan, Billings, Paul, Reese, Martin G., Yandell, Mark, Kingsmore, Stephen F.“…RESULTS: GEM ranked over 90% of the causal genes among the top or second candidate and prioritized for review a median of 3 candidate genes per case, using either manually curated or CNLP-derived phenotype descriptions. Ranking of trios and duos was unchanged when analyzed as singletons. …”
Publicado 2021
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28988“…Species with the recorded highest consensus for curative purposes are useful sources for further phytochemical and pharmacological validation for better utilization. …”
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28989por Maruta, Akinori, Iwashita, Takuji, Yoshida, Kensaku, Uemura, Shinya, Yasuda, Ichiro, Shimizu, Masahito“…In the prognostic study, 256 patients with curative R0 or R1 had a recurrence rate was 54.3% (70/129) in the FNA group and 57.4% (73/127) in the non-FNA group. …”
Publicado 2021
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28990por vd Wiel, Hester J, Stuiver, Martijn M, May, Anne M, van Grinsven, Susan, Benink, Marlou F A, Aaronson, Neil K, Oldenburg, Hester S A, van der Poel, Henk G, van Harten, Wim H, Groen, Wim G“…METHODS: Breast and prostate cancer survivors, 3-36 months after primary curative treatment, were invited to participate in the PABLO trial; this trial compared an internet-based intervention to enhance PA levels, with or without additional support from a physical therapist, to usual care. …”
Publicado 2021
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28991por Jin, Peng, Liu, Hao, Ma, Fu-Hai, Ma, Shuai, Li, Yang, Xiong, Jian-Ping, Kang, Wen-Zhe, Hu, Hai-Tao, Tian, Yan-Tao“…Multivariate analysis identified neoadjuvant chemotherapy [hazard ratio (HR) 0.290, 95% confidence interval (CI): 0.103–0.821, P = 0.020], linitis plastic (HR 2.614, 95% CI: 1.024–6.675, P = 0.033), surgical margin (HR 0.274, 95% CI: 0.102–0.738, P = 0.010), N stage (HR 3.489, 95% CI: 1.334–9.120, P = 0.011), and postoperative chemoradiotherapy (HR 0.369, 95% CI: 0.163–0.836, P = 0.017) as independent predictors of survival in patients with pT4b gastric cancer and pancreatic head invasion. CONCLUSION: Curative resection of the invaded pancreas should be performed to improve survival in selected patients. …”
Publicado 2021
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28992por Pearce, Christopher, McLeod, Adam, Supple, Jamie, Gardner, Karina, Proposch, Amanda, Ferrigi, Jason“…Data cleaning for analysis uses a variety of techniques, including Natural Language Processing and coding of free text information. The curated dataset is then distilled into several analytic solutions designed to address specific areas of investigation of interest to various stakeholders. …”
Publicado 2022
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28993por Wu, Ann Chen, McMahon, Pamela M, Welch, Emily, McMahill-Walraven, Cheryl N, Jamal-Allial, Aziza, Gallagher, Mia, Zhang, Tancy, Draper, Christine, Kline, Anne Marie, Koerner, Leslie, Brown, Jeffrey S, Van Dyke, Melissa K“…METHODS: We conducted a new-user observational cohort study using data from Aetna, a CVS Health Company, HealthCore (Anthem), Harvard Pilgrim Healthcare, and IBM MarketScan Research Databases. Curated administrative claims data in the FDA Sentinel System common data model format and publicly available Sentinel analytical tools were used to query the databases. …”
Publicado 2021
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28994por Javorcikova, Zuzana, Dangoisse, Michel, Nikis, Stéphane, Lechat, Jean-Paul, Gillain, Aline, Fils, Jean-François, Van der Linden, Philippe“…BACKGROUND: Fibromyalgia is a chronic multidimensional pain disease with no curative treatment currently available. Its management relies on a multimodal approach involving pharmacologic and non-pharmacologic elements. …”
Publicado 2021
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28995por Salim, Nesreen A., Alamoush, Rasha A., Al-Abdallah, Mariam Mohammad, Al-Asmar, Aya Ahmed, Satterthwaite, Julian D.“…CONCLUSION: Malocclusion may increase the risk of caries and periodontal disease; the magnitude of this risk is amplified in populations with poor oral health and limited access to oral healthcare services, highlighting the need for preventive and curative oral health programs.…”
Publicado 2021
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28996por Ahn, Imjin, Gwon, Hansle, Kang, Heejun, Kim, Yunha, Seo, Hyeram, Choi, Heejung, Cho, Ha Na, Kim, Minkyoung, Jun, Tae Joon, Kim, Young-Hak“…METHODS: We set up the cohort criteria and extracted the data from CardioNet, a manually curated database that specializes in CVDs. We processed the data to create a suitable data set by reindexing the date-index, integrating the present features with past features from the previous 3 years, and imputing missing values. …”
Publicado 2021
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28997por Liu, Lin, Fan, Shicai, Zeng, Donggui, Chen, Yuhui, Song, Hui, Zeng, Letian, Jin, Dadi“…CONCLUSION: An anterior ring internal fixator system combined with sacroiliac screw fixation can effectively treat Tile C pelvic fracture, and has advantages, including minimal invasiveness, simple operation, short operative time, safe and reliable features, fewer complications, short hospital stay and a good curative effect.…”
Publicado 2021
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28998por Yang, Yunpeng, Zhou, Ting, Chen, Xiaozhong, Li, Jingao, Pan, Jianji, He, Xiaohui, Lin, Lizhu, Shi, Ying-rui, Feng, Weineng, Xiong, Jianping, Yang, Kunyu, Yu, Qitao, Zhang, Qunling, Hu, Desheng, Sun, Yan, Hu, Guangyuan, Li, Ping, Shen, Liangfang, Lin, Qin, Zhang, Ben, Qu, Xiao, Zou, Jianjun, Zhang, Li, Fang, Wenfeng, Zhao, Yuanyuan“…METHODS: Patients with recurrent (not amenable to locally curative treatment) or metastatic NPC who had failed at least two lines of chemotherapy were eligible to receive camrelizumab (200 mg intravenously every 2 weeks) for 2 years or until disease progression, intolerable adverse events, withdrawal of consents, or investigator decision. …”
Publicado 2021
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28999“…Sur le plan thérapeutique, 85 % étaient mis sous oxygénothérapie : 61 % sous lunettes, 25 % sous masque à haute concentration et 14 % sous VNI ; la corticothérapie était prescrite chez 61 %, le traitement antibiotique chez 70 %, 100 % des patients avaient pris le traitement anticoagulant avec une dose curative ou préventive. L’évolution des patients était favorable dans 70 %, les accidents thromboemboliques 24 %, l’insuffisance respiratoire chronique 4 % et les décès 14 %. …”
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29000por Hitz, Anna-Maria, Bläsing, Kim-Alina, Wiegmann, Bettina, Bellmàs-Sanz, Ramon, Chichelnitskiy, Evgeny, Wandrer, Franziska, Horn, Lisa-Marie, Neudörfl, Christine, Keil, Jana, Beushausen, Kerstin, Ius, Fabio, Sommer, Wiebke, Avsar, Murat, Kühn, Christian, Tudorache, Igor, Salman, Jawad, Siemeni, Thierry, Haverich, Axel, Warnecke, Gregor, Falk, Christine S., Kühne, Jenny F.“…INTRODUCTION: For end-stage lung diseases, double lung transplantation (DLTx) is the ultimate curative treatment option. However, acute and chronic rejection and chronic dysfunction are major limitations in thoracic transplantation medicine. …”
Publicado 2021
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