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29101por Čerina, Dora, Krpina, Kristina, Jakopović, Marko, Dedić Plavetić, Natalija, Seiwerth, Fran, Tomić, Snježana, Radić, Jasna, Belac Lovasić, Ingrid, Canjko, Ivana, Boban, Marijo, Samaržija, Miroslav, Vrdoljak, Eduard“…Consequently, the implementation of the precision oncology concept in medical systems, in order to achieve optimal and proven curative effects in NSCLC, is imperative. In this study, we investigated the development, challenges, and results associated with the implementation of precision oncology in NSCLC on a national level in Croatia. …”
Publicado 2023
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29102por Sebastian, Nikhil, Goyal, Subir, Liu, Yuan, Janopaul-Naylor, James R., Patel, Pretesh R., Dhere, Vishal R., Hanasoge, Sheela, Shelton, Jay W., Godette, Karen D., Jani, Ashesh B., Hershatter, Bruce, Fischer-Valuck, Benjamin, Patel, Sagar A.“…Patients included men diagnosed with nonmetastatic VHR prostate cancer by National Comprehensive Cancer Network criteria (clinical T3b-T4 category, primary Gleason pattern 5, >4 cores with grade group 4-5, and/or 2-3 high-risk features) and treated with curative-intent radiotherapy and androgen deprivation therapy between January 1, 2004, to December 31, 2016. …”
Publicado 2023
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29103por Katalinic, Alexander, Halber, Marco, Meyer, Martin, Pflüger, Maren, Eberle, Andrea, Nennecke, Alice, Kim-Wanner, Soo-Zin, Hartz, Tobias, Weitmann, Kerstin, Stang, Andreas, Justenhoven, Christina, Holleczek, Bernd, Piontek, Daniela, Wittenberg, Ian, Heßmer, Annika, Kraywinkel, Klaus, Spix, Claudia, Pritzkuleit, Ron“…Therapy data for rectal cancer in 2019–2021 from the CR SH are shown as an example: 69% of the registered patients underwent surgery, mostly with curative intent (84%) and tumour-free resection (91%). …”
Publicado 2023
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29104por Fröhlich, Fabienne, Ramelyte, Egle, Turko, Patrick, Dzung, Andreas, Freiberger, Sandra N., Mangana, Joanna, Levesque, Mitchell P., Dummer, Reinhard“…However, the cohort’s mutational profiles closely matched three known mutational signatures curated by the Catalog of Somatic Mutations in Cancer (COSMIC): UV signature COSMIC_7 (cosine-similarity 0.932), clock-like signature COSMIC_5 (cosine-similarity 0.829), and COSMIC_30 (cosine-similarity 0.726). …”
Publicado 2023
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29105por Ambrosio, Frank J., Scribner, Michelle R., Wright, Sage M., Otieno, James R., Doughty, Emma L., Gorzalski, Andrew, Siao, Danielle Denise, Killian, Steve, Hua, Chi, Schneider, Emily, Tran, Michael, Varghese, Vici, Libuit, Kevin G., Pandori, Mark, Sevinsky, Joel R., Hess, David“…RESULTS: A primary result of this work is a curated fungal database containing 5,667 unique genomes representing 245 species. …”
Publicado 2023
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29106“…The indirect impact of ApoA-I explained over 50% of the curative effects of CETP inhibitors in sepsis. CONCLUSIONS: Our MR study suggested that ApoA-I and HDL-C protected against sepsis, while HMGCR and CETP inhibitors showed therapeutic potential beyond lipid-lowering effects. …”
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29107por Abdusalomov, Akmalbek Bobomirzaevich, Mukhiddinov, Mukhriddin, Whangbo, Taeg Keun“…To further improve the training of our proposed model, we apply data augmentation techniques to the openly accessible brain tumor dataset. The curated data include a wide variety of cases, such as 2548 images of gliomas, 2658 images of pituitary, 2582 images of meningioma, and 2500 images of non-tumors. …”
Publicado 2023
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29108“…Patients with recurrent HCC in the UEBMI were more likely to receive curative therapy (p < 0.001) and less likely to receive supportive care (p < 0.001). …”
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29109por Turcu, Adina F, Lee, Chaelin, Salman, Zara, Liu, Haiping, Rabbah, Amira, Marie Konzen, Sonja, Rainey, William E, Giordano, Thomas J, Zhao, Lili, Udager, Aaron“…Adrenal vein sampling (AVS)-guided unilateral adrenalectomy is often curative in patients with APA and offers marked cardiovascular and renal benefits. …”
Publicado 2023
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29110“…She was eventually diagnosed with adenocarcinoma in 2 colonic polyps and underwent a curative pan-proctocolectomy. The other patient was diagnosed clinically with FAP as she had multiple (30-40) colonic polyps which were tubular adenomas. …”
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29111“…Removal of the tumor is curative, though it can sometimes be a challenge to localize. …”
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29112por Devon, Karen M, Zahedi, Afshan, Madani, Amin, Pasternak, Jesse D, Saravana-Bawan, Bianka, Humar, Atul, Kathryn, Tinckam“…We are currently recruiting additional patients with the aim of demonstrating that deceased donor parathyroid allotransplant using fresh tissue and immunosuppression is a novel viable and curative approach to treat permanent severe hypoparathyroidism. …”
Publicado 2023
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29113“…Owing to increased mortality of untreated CS, it is essential for adequate identification of cause for curative therapy. We promote a non-invasive approach using the desmopressin stimulation test for successful identification in patients with discordant serum and imaging results. …”
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29114por Anandakrishnan, Manju, Ross, Karen E., Chen, Chuming, Shanker, Vijay, Cowart, Julie, Wu, Cathy H.“…We employ KSFinder to predict substrates of 68 “dark” kinases considered understudied by the Illuminating the Druggable Genome program and use our text-mining tool, RLIMS-P along with manual curation, to search for literature evidence for the predictions. …”
Publicado 2023
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29115por Nachankar, Ankita, Schafasand, Mansure, Carlino, Antonio, Hug, Eugen, Stock, Markus, Góra, Joanna, Fossati, Piero“…SIMPLE SUMMARY: Carbon-ion radiotherapy (CIRT) is a potentially curative treatment for unresectable pelvic sarcomas/chordomas. …”
Publicado 2023
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29116por Horton, Carolyn, Hoang, Lily, Zimmermann, Heather, Young, Colin, Grzybowski, Jessica, Durda, Kate, Vuong, Huy, Burks, David, Cass, Ashley, LaDuca, Holly, Richardson, Marcy E., Harrison, Steven, Chao, Elizabeth C., Karam, Rachid“…Demographic characteristics, clinical data, and test results were curated as samples were received, and changes to variant classification were assessed over time. …”
Publicado 2023
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29117“…Exploration of new decapping enzymes or engineering of already known enzymes could lead to improvements in NAD-specific protocols. The use of a curated set of decapping enzymes in a combinatorial approach could allow for the simultaneous detection of multiple 5′-caps. …”
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29118por Trevisani, Lorenzo Fernandes Moça, Kulcsar, Isabelle Fernandes, Kulcsar, Marco Aurélio Vamondes, Dedivitis, Rogerio Aparecido, Kowalski, Luiz Paulo, Matos, Leandro Luongo“…Methods: This retrospective cohort study included patients with oral squamous cell carcinoma (OSCC) who underwent curative-intent treatment. Treatment encompassed surgery, followed by adjuvant therapy, as necessary. …”
Publicado 2023
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29119“…Comprehensive databases, like TORGO and UA-Speech, were commonly used in combination with other curated databases, while primary data was preferred for specific or unique research objectives. …”
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29120por Martin-Hernandez, Roberto, Espeso-Gil, Sergio, Domingo, Clara, Latorre, Pablo, Hervas, Sergi, Hernandez Mora, Jose Ramon, Kotelnikova, Ekaterina“…Additional regulators of the identified signature were discovered using Clarivate CBDD (Computational Biology for Drug Discovery) network propagation and hidden nodes algorithms on a curated network of molecular interactions (MetaBase™). …”
Publicado 2023
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