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  1. 29501
    “…The determination of the dose–efficacy relationship of ACT-451840 under curative conditions in rodent malaria models allowed prediction of the human efficacious exposure. …”
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    Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling
  2. 29502
    “…OBJECTIVE: The aim of this study was to analyze the reliability of a tablet-based measuring application for EORTC QLQ-C30 in German language in patients with adjuvant and (curative) metastatic breast cancer. METHODS: Paper- and tablet-based questionnaires were completed by a total of 106 female patients with adjuvant and metastatic breast cancer recruited as part of the e-PROCOM study. …”
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    Reliability of an e-PRO Tool of EORTC QLQ-C30 for Measurement of Health-Related Quality of Life in Patients With Breast Cancer: Prospective Randomized Trial
  3. 29503
    “…While challenging, the development of tools suitable for deployment as single encounter curative treatments for adults and children in Africa and to support elimination strategies remains a key development goal. …”
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    A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria
  4. 29504
    por Bahig, Houda, Yuan, Ying, Mohamed, Abdallah S.R., Brock, Kristy K., Ng, Sweet Ping, Wang, Jihong, Ding, Yao, Hutcheson, Kate, McCulloch, Molly, Balter, Peter A., Lai, Stephen Y., Al-Mamgani, Abrahim, Sonke, Jan-Jakob, van der Heide, Uulke A., Nutting, Christopher, Li, X. Allen, Robbins, Jared, Awan, Mussadiq, Karam, Irene, Newbold, Katherine, Harrington, Kevin, Oelfke, Uwe, Bhide, Shreerang, Philippens, Marielle E.P., Terhaard, Chris H.J., McPartlin, Andrew J., Blanchard, Pierre, Garden, Adam S., Rosenthal, David I., Gunn, Gary B., Phan, Jack, Cazoulat, Guillaume, Aristophanous, Michalis, McSpadden, Kelli K., Garcia, John A., van den Berg, Cornelis A.T., Raaijmakers, Cornelis P.J., Kerkmeijer, Linda, Doornaert, Patricia, Blinde, Sanne, Frank, Steven J., Fuller, Clifton D.
    Publicado 2018
    “…METHODS: Patients with T1-2 N0-2b (as per AJCC 7th Edition) HPV-positive OPC, with lymph node <3 cm and <10 pack-year smoking history planned for curative radiotherapy alone to a dose of 70 Gy in 33 fractions will be eligible. …”
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    Magnetic Resonance-based Response Assessment and Dose Adaptation in Human Papilloma Virus Positive Tumors of the Oropharynx treated with Radiotherapy (MR-ADAPTOR): An R-IDEAL stage 2a-2b/Bayesian phase II trial
  5. 29505
    “…METHODS: A total of 213,908 HCV sequences available as of July 10, 2019 were retrieved from the NCBI nucleotide database. After curation, 17,312 NS3, 8,478 NS5A, and 25,991 NS5B sequence fragments from DAA-naïve patients were screened for RASs. …”
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    Computational analysis of naturally occurring resistance-associated substitutions in genes NS3, NS5A, and NS5B among 86 subtypes of hepatitis C virus worldwide
  6. 29506
    “…The trial objectives are: 1) To test the effect of a multidisciplinary residential nutritional rehabilitation programme compared to standard care on the primary outcome body weight and secondary outcomes health-related quality of life, physical function and symptoms of anxiety and depression in patients curatively treated for HNC and 2) To test for correlations between participants’ development in outcome scores during their participation in the programme and their baseline scores in Nutritional Risk Screening 2002 (NRS 2002), the Scored Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF), and M. …”
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    Rationale and design of a randomised controlled trial investigating the effect of multidisciplinary nutritional rehabilitation for patients treated for head and neck cancer (the NUTRI-HAB trial)
  7. 29507
    “…The 100 general practices currently undertaking annual influenza virology surveillance will be involved in the extended virological and serological surveillance. (4) Collecting convalescent serum samples. (5) Data curation. We have the opportunity to escalate the data extraction to twice weekly if needed. …”
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    Emergence of a Novel Coronavirus (COVID-19): Protocol for Extending Surveillance Used by the Royal College of General Practitioners Research and Surveillance Centre and Public Health England
  8. 29508
    “…To overcome morbidity and mortality from diarrheal diseases among children in the context of severe information shortages, a predictive model is needed to determine the burden of diarrheal disease on Yemeni children and their ability to reach curative health services through an estimate of healthcare coverage. …”
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    A predictive model for healthcare coverage in Yemen
  9. 29509
    “…BACKGROUND: Early detection of colorectal carcinoma (CRC) would help to identify tumors when curative treatments are available and beneficial. However, current screening methods for CRC, e.g., colonoscopy, may affect patients’ compliance due to the uncomfortable, invasive and time-consuming process. …”
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    Discovery and validation of methylation signatures in blood-based circulating tumor cell-free DNA in early detection of colorectal carcinoma: a case–control study
  10. 29510
    “…RESULTS: The clinical curative effect of the elastic nailing group was higher than that of the control group 16 months after operation (96.00% > 73.91%, P < 0.05). …”
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    Comparative efficacy and safety profile for the treatment of humeral bone cysts in children: curettage and mixed bone grafting either with or without elastic intramedullary nailing
  11. 29511
    “…We hypothesized that ultrasound-guided administration of MSCs combined with greater omentum might be more curative than currently available approaches. METHODS: In this study, we established an aristolochic acid nephropathy (AAN) model by intraperitoneally administering aristolochic acid I sodium salt (AA-I) at a dose of 5 mg/kg body weight on alternate days for 4 weeks. …”
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    Ultrasound enhances the therapeutic potential of mesenchymal stem cells wrapped in greater omentum for aristolochic acid nephropathy
  12. 29512
    “…By combining these B cell and T cell analyses, as well as a manufacturability heuristic, we proposed a set of 22 SARS-CoV-2 vaccine peptides for use in subsequent murine studies. We curated a dataset of ~ 1000 observed T cell epitopes from convalescent COVID-19 patients across eight studies, showing 8/15 recurrent epitope regions to overlap with at least one of our candidate peptides. …”
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    Landscape and selection of vaccine epitopes in SARS-CoV-2
  13. 29513
    por Li, Shuying, Yin, Yan, Xiao, Dan, Zou, Yong
    Publicado 2021
    “…CONCLUSION: The supplementary treatment of bifid triple viable capsules can effectively enhance the curative effect in ulcerative colitis patients, reduce plasma inflammatory factors, and regulate T cell frequency, which is worthy of clinical application.…”
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    Supplemental bifid triple viable capsule treatment improves inflammatory response and T cell frequency in ulcerative colitis patients
  14. 29514
    “…For both muscle diseases, no curative treatment options exist, yet promising preclinical studies are ongoing. …”
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    Natural history, outcome measures and trial readiness in LAMA2-related muscular dystrophy and SELENON-related myopathy in children and adults: protocol of the LAST STRONG study
  15. 29515
    “…Child/mother or caretaker pairs who visits outpatient department for curative care service or follow up were recruited for the study. …”
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    Acute lower respiratory tract infections and associated factors among under-five children visiting Wolaita Sodo University Teaching and Referral Hospital, Wolaita Sodo, Ethiopia
  16. 29516
    “…RESULTS: Of 808 individuals assessed by sequencing, 69 (9%) had pdSNV in the 102 ASC genes, and 144 (18%) had pdSNV in the 102 ASC genes or in a larger set of curated neurodevelopmental genes (from the Deciphering Developmental Disorders study, the gene2phenotype database, and the Radboud University gene lists). …”
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    Prevalence and phenotypic impact of rare potentially damaging variants in autism spectrum disorder
  17. 29517
    “…BACKGROUND: Immunotherapy is a valuable option for cancer treatment, and the curative effect of anti-PD-1/PD-L1 therapy correlates closely with PD-L1 expression levels. …”
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    Dose escalation biodistribution, positron emission tomography/computed tomography imaging and dosimetry of a highly specific radionuclide-labeled non-blocking nanobody
  18. 29518
    “…BACKGROUND: The BOLT study for sonidegib, a Hedgehog pathway inhibitor (HHI) approved for patients with locally advanced basal cell carcinoma (laBCC) not amenable to curative surgery or radiotherapy, used modified Response Evaluation Criteria in Solid Tumors (mRECIST) for laBCC tumor evaluation. …”
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    Assessment of various efficacy outcomes using ERIVANCE-like criteria in patients with locally advanced basal cell carcinoma receiving sonidegib: results from a preplanned sensitivity analysis
  19. 29519
    “…Here, 87 metagenomes and five viral size-fraction metagenomes (viromes) from a boreal peatland in northern Minnesota (the SPRUCE whole-ecosystem warming experiment and surrounding bog) were analyzed for dsDNA viral community ecological patterns, and the recovered viral populations (vOTUs) were compared with our curated PIGEON database of 266,125 vOTUs from diverse ecosystems. …”
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    Minnesota peat viromes reveal terrestrial and aquatic niche partitioning for local and global viral populations
  20. 29520
    “…BACKGROUND: An increasing number of patients reach the final stage of heart failure with heart transplantation as the only curative treatment. Mechanical circulatory support, such as left ventricular assist devices (LVAD) are becoming increasingly more important at this stage of the disease. …”
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    „Palliative care“ bei Patienten mit Linksherzunterstützungssystem: systematische Übersichtsarbeit
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