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Mostrando 2,121 - 2,140 Resultados de 2,862 Para Buscar '"data integrity"', tiempo de consulta: 0.44s Limitar resultados
  1. 2121
    “…In this paper, we show how seeing the spatial organization of chromosomes can bring new perspectives to omics data integration. We assembled state-of-the-art tools into a workflow that goes from Hi-C raw data to fully annotated 3D models and we re-analysed public omics datasets available for three fungal species. …”
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    3D models of fungal chromosomes to enhance visual integration of omics data
  2. 2122
    “…After 4 weeks, trace metals (cadmium, chromium, copper, iron, manganese, nickel, lead, and zinc) and polycyclic aromatic hydrocarbons (PAHs) were measured and these data integrated with the analyses of molecular and biochemical responses. …”
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    Use of the Land Snail Helix aspersa as Sentinel Organism for Monitoring Ecotoxicologic Effects of Urban Pollution: An Integrated Approach
  3. 2123
    “…Furthermore, even in the case of the widely-used, industry-standard Affymetrix oligonucleotide microarrays, the various array generations have different probe sets representing different genes, hindering the data integration. RESULTS: In this study our objective is to find systematic approaches to normalize the data emerging from different Affymetrix array generations and from different laboratories. …”
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    Comparison of Affymetrix data normalization methods using 6,926 experiments across five array generations
  4. 2124
    “…Metabolic network reconstructions represent valuable scaffolds for ‘-omics’ data integration and are used to computationally interrogate network properties. …”
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    Genome-Scale Reconstruction of Escherichia coli's Transcriptional and Translational Machinery: A Knowledge Base, Its Mathematical Formulation, and Its Functional Characterization
  5. 2125
    “…This approach limits the CL's utility for computation and for cross-species data integration. RESULTS: To enhance the CL's utility for computational analyses, we developed a method for the ontological representation of cells and applied this method to develop a dendritic cell ontology (DC-CL). …”
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    An improved ontological representation of dendritic cells as a paradigm for all cell types
  6. 2126
    “…CONCLUSION: We demonstrate that CFA is a useful tool for gene-protein data integration and modeling, where the main question is in finding which patterns of gene expression are most correlated with protein expression.…”
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    Correlating gene and protein expression data using Correlated Factor Analysis
  7. 2127
    “…In contrast to other microarray-related web-tools, multiple algorithms and data sets for an analysis task can be combined using ensemble feature selection, ensemble prediction, consensus clustering and cross-platform data integration. By interlinking different analysis tools in a modular fashion, new exploratory routes become available, e.g. ensemble sample classification using features obtained from a gene set analysis and data from multiple studies. …”
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    ArrayMining: a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalization
  8. 2128
    “…We then demonstrate many of the issues and benefits of multi-resolution data integration. CONCLUSIONS: Genome3D is a software visualization tool that explores a wide range of structural genomic and epigenetic data. …”
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    Genome3D: A viewer-model framework for integrating and visualizing multi-scale epigenomic information within a three-dimensional genome
  9. 2129
    “…More microRNA specific normalization methods are in demand for cross-platform microRNA microarray data integration and comparison, which will improve the reproducibility and consistency between platforms.…”
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    Systematic Evaluation of Three microRNA Profiling Platforms: Microarray, Beads Array, and Quantitative Real-Time PCR Array
  10. 2130
    “…In addition, to detect the potential for data integration, we constructed statistical compensation models using linear regression analysis with residual analysis, and presented the R-square values. …”
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    Reliability of Quadruplicated Serological Parameters in the Korean Genome and Epidemiology Study
  11. 2131
    “…In this work we propose a novel data integration approach that utilises semantic kernels and a kernel classification method that is a probabilistic analogue to SVMs. …”
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    Protein interaction sentence detection using multiple semantic kernels
  12. 2132
    “…Our work reveals the complementarity between physical evidence of regulatory interactions (TF binding, motif conservation) and functional evidence (coordinated expression or chromatin patterns) and demonstrates the power of data integration for network inference and studies of gene regulation at the systems level.…”
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    Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks
  13. 2133
    “…Nevertheless, this concept has its relevance in epidemiology, such as for data integration within mortality notification systems. …”
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    Towards an ontological representation of morbidity and mortality in Description Logics
  14. 2134
    “…Together, our findings suggest that encapsulation and multinucleated giant cells control M. bovis viability, whereas neutrophils may serve as a cellular biomarker of bacterial proliferation during natural infection. These data integrate host granuloma responses with mycobacterial dissemination and could provide useful immunopathological-based biomarkers of disease severity in natural infection with M. bovis, an important cattle pathogen.…”
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    Asymptomatic Cattle Naturally Infected with Mycobacterium bovis Present Exacerbated Tissue Pathology and Bacterial Dissemination
  15. 2135
    “…However, the difficulties in data management and the complexities of analytical approaches have significantly limited data integration to enable meta-analysis. Here, we introduce integrative meta-analysis of expression data (INMEX), a user-friendly web-based tool designed to support meta-analysis of multiple gene-expression data sets, as well as to enable integration of data sets from gene expression and metabolomics experiments. …”
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    INMEX—a web-based tool for integrative meta-analysis of expression data
  16. 2136
    “…Taken together, these data integrated micro RNA expression and function into GATA factor coordinated networks and provided mechanistic insight into a regulatory circuit that comprised GATA1/2 switch and miR-27a/24 in erythropoiesis.…”
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    A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis
  17. 2137
    “…Therefore, it is needed to filter out contaminated gene expression data before further data integration and analysis. RESULTS: Firstly, we adopt a dynamic model-based method to filter noisy data from dynamic expression profiles. …”
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    Detecting protein complexes from active protein interaction networks constructed with dynamic gene expression profiles
  18. 2138
    “…To address the issues, a seamless information system was developed at Institut Curie which facilitates the data integration and tracks in real-time the processing of individual samples. …”
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    Bioinformatics for precision medicine in oncology: principles and application to the SHIVA clinical trial
  19. 2139
    “…Computational removal of nodes from the Boolean network model was also used to predict lineage specification outcomes. In summary, data integration, modeling, and targeted experiments were used to improve our understanding of the regulatory topology that controls mESC fate decisions as well as to develop robust directed lineage specification protocols.…”
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    Construction and Validation of a Regulatory Network for Pluripotency and Self-Renewal of Mouse Embryonic Stem Cells
  20. 2140
    “…The data analyses included both thematic and the Systematic Data Integration approach. RESULTS: Two contrasting types of collaboration emerged from the analyses; knowledge sharing and information exchange. …”
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    User involvement as sharing knowledge – an extended perspective in patient education
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