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  1. 1221
    “…In this review, we highlight common approaches to genomic data integration and provide a transparent benchmarking procedure to quantitatively compare method performances in cancer gene prioritization. …”
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    Online Artículo Texto
    Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review
  2. 1222
    “…The essential contribution of the work reported here lies in the novel data integration and reporting methods, as well as the approach to software sustainability achieved through the use of community-supported open-source components.…”
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    Online Artículo Texto
    Hadron therapy information sharing prototype
  3. 1223
    por Koscielny, Gautier, An, Peter, Carvalho-Silva, Denise, Cham, Jennifer A., Fumis, Luca, Gasparyan, Rippa, Hasan, Samiul, Karamanis, Nikiforos, Maguire, Michael, Papa, Eliseo, Pierleoni, Andrea, Pignatelli, Miguel, Platt, Theo, Rowland, Francis, Wankar, Priyanka, Bento, A. Patrícia, Burdett, Tony, Fabregat, Antonio, Forbes, Simon, Gaulton, Anna, Gonzalez, Cristina Yenyxe, Hermjakob, Henning, Hersey, Anne, Jupe, Steven, Kafkas, Şenay, Keays, Maria, Leroy, Catherine, Lopez, Francisco-Javier, Magarinos, Maria Paula, Malone, James, McEntyre, Johanna, Munoz-Pomer Fuentes, Alfonso, O'Donovan, Claire, Papatheodorou, Irene, Parkinson, Helen, Palka, Barbara, Paschall, Justin, Petryszak, Robert, Pratanwanich, Naruemon, Sarntivijal, Sirarat, Saunders, Gary, Sidiropoulos, Konstantinos, Smith, Thomas, Sondka, Zbyslaw, Stegle, Oliver, Tang, Y. Amy, Turner, Edward, Vaughan, Brendan, Vrousgou, Olga, Watkins, Xavier, Martin, Maria-Jesus, Sanseau, Philippe, Vamathevan, Jessica, Birney, Ewan, Barrett, Jeffrey, Dunham, Ian
    Publicado 2017
    “…We have designed and developed a data integration and visualization platform that provides evidence about the association of known and potential drug targets with diseases. …”
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    Online Artículo Texto
    Open Targets: a platform for therapeutic target identification and validation
  4. 1224
    “…However, until now, this task has required dedicated bioinformatics support to perform the necessary data integration. GenomeSpace provides a protocol, or “recipe”, and a user interface with inter-operating software tools to identify protein occupancies along the genome from a ChIP-seq experiment and associated differentially regulated genes from a RNA-Seq experiment. …”
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    Online Artículo Texto
    A multi-tool recipe to identify regions of protein-DNA binding and their influence on associated gene expression
  5. 1225
    “…Further, when attempting to integrate data, differences in existing datasets also impose challenges that limit opportunities for data integration. As a result, the pace of scientific advancements is suboptimal. …”
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    Online Artículo Texto
    Virtual Cohorts and Synthetic Data in Dementia: An Illustration of Their Potential to Advance Research
  6. 1226
    “…They are often aimed at benchmarking bioinformatics algorithms for purposes such as sample classification, differential expression analysis, correlation and network studies and the optimization of data integration and normalization techniques. Here, we propose a general framework to compare synthetically generated RNA-seq data and select a data-generating tool that is suitable for a set of specific study goals. …”
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    Online Artículo Texto
    A Framework for Comparison and Assessment of Synthetic RNA-Seq Data
  7. 1227
    “…Our implementation uses the RDF Data Model in Oracle Database 10g release 2 for data integration, query, and inference, while our Web interface allows users to query the data and retrieve the results in a convenient fashion. …”
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    AlzPharm: integration of neurodegeneration data using RDF
  8. 1228
    “…The quality of the forecast depends on the level of data integration, thus stressing the need for high-quality data in population-based models, and of progressive updates of validated available empirical knowledge to inform these models.…”
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    Online Artículo Texto
    Real-time numerical forecast of global epidemic spreading: case study of 2009 A/H1N1pdm
  9. 1229
    por Nie, Yaling, Yu, Jingkai
    Publicado 2013
    “…However, different types of data often contain varying degrees of noise. For effective data integration, it’s important to design methods that work robustly with respect to noise. …”
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    Online Artículo Texto
    Mining breast cancer genes with a network based noise-tolerant approach
  10. 1230
    “…In parallel, the development of recent whole-cell models using a systemic cell description opened alternatives for data integration. Integrating a systemic cell description within a bio-ontology would help to progress in whole-cell data integration and modeling synergistically. …”
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    Online Artículo Texto
    The bacterial interlocked process ONtology (BiPON): a systemic multi-scale unified representation of biological processes in prokaryotes
  11. 1231
    “…This review highlights critical advances and challenges in omics data analysis, dealing with data variability from lab-to-lab, and data integration. We also describe methods used in data mining and AI methods to obtain robust results for precision medicine from “big” data. …”
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    Online Artículo Texto
    Artificial Intelligence to Decode Cancer Mechanism: Beyond Patient Stratification for Precision Oncology
  12. 1232
    por Li, Binglan, Ritchie, Marylyn D.
    Publicado 2021
    “…We categorize and describe two types of data integrative methods. First, we describe fine-mapping methods. …”
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    Online Artículo Texto
    From GWAS to Gene: Transcriptome-Wide Association Studies and Other Methods to Functionally Understand GWAS Discoveries
  13. 1233
    “…Moreover, we propose a multi-omics data integration method by jointly modeling the proposed MRS and other risk scores constructed from other omics data in disease prediction. …”
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    Online Artículo Texto
    Microbial Risk Score for Capturing Microbial Characteristics, Integrating Multi-omics Data, and Predicting Disease Risk
  14. 1234
    “…BACKGROUND: Genomic and biosocial research data about individuals is rapidly proliferating, bringing the potential for novel opportunities for data integration and use. The scale, pace and novelty of these applications raise a number of urgent sociotechnical, ethical and legal questions, including optimal methods of data storage, management and access. …”
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    Online Artículo Texto
    Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure
  15. 1235
    “…Participating sites of the German Medical Informatics Initiative (MII) established data integration centers to integrate EHR data within research data repositories to support local and federated analyses. …”
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    Online Artículo Texto
    Linking a Consortium-Wide Data Quality Assessment Tool with the MIRACUM Metadata Repository
  16. 1236
    “…Finally, phase 3 will include data integration and dissemination of key findings and recommendations. …”
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    Online Artículo Texto
    Self-compassion Education for Health Professionals (Nurses and Midwives): Protocol for a Sequential Explanatory Mixed Methods Study
  17. 1237
    por Pačínková, Anna, Popovici, Vlad
    Publicado 2023
    “…We present a new comprehensive R/Bioconductor-package, IntOMICS, which implements a Bayesian framework for multi-omics data integration. IntOMICS adopts a Markov Chain Monte Carlo sampling scheme to systematically analyze gene expression, copy number variation, DNA methylation, and biological prior knowledge to infer regulatory networks. …”
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    Online Artículo Texto
    IntOMICS: A Bayesian Framework for Reconstructing Regulatory Networks Using Multi-Omics Data
  18. 1238
    “…We provide an overview of the state-of-the-art research for clinical and biomedical data integration and summarize the potential to accelerate healthcare and precision medicine research through insight generation from integrated knowledge graphs.…”
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    Online Artículo Texto
    From Data to Wisdom: Biomedical Knowledge Graphs for Real-World Data Insights
  19. 1239
    por Sen, Partho, Orešič, Matej
    Publicado 2023
    “…Recent advancements in omics technologies have generated a wealth of biological data. Integrating these data within mathematical models is essential to fully leverage their potential. …”
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    Online Artículo Texto
    Integrating Omics Data in Genome-Scale Metabolic Modeling: A Methodological Perspective for Precision Medicine
  20. 1240
    “…Although various software tools and packages have been developed for this purpose, challenges persist in terms of user-friendly accessibility, data integration, and interactivity. In this study, we introduce Spatial-Live, a lightweight and versatile viewer tool designed for flexible single-cell spatial-omics data visualization. …”
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    Online Artículo Texto
    Spatial-Live: A lightweight and versatile tool for single cell spatial-omics data visualization
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