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  1. 1241
    “…We present here our new repository for next generation sequence data, a brief summary of contents of the ENA and provide details of major developments to submission pipelines, high-throughput rule-based validation infrastructure and data integration approaches.…”
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    Petabyte-scale innovations at the European Nucleotide Archive
  2. 1242
    “…The current version builds upon previous versions by the addition of new, complete sets of homeodomain sequences from fully sequenced genomes, the expansion of existing curated homeodomain information and the improvement of data accessibility through better search tools and more complete data integration. This release contains 1534 full-length homeodomain-containing sequences, 93 experimentally derived homeodomain structures, 101 homeodomain protein–protein interactions, 107 homeodomain DNA-binding sites and 206 homeodomain proteins implicated in human genetic disorders. …”
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    The Homeodomain Resource: a comprehensive collection of sequence, structure, interaction, genomic and functional information on the homeodomain protein family
  3. 1243
    “…However, the job of harmonising reporting standards is still very much a work in progress; both software interoperability and the data integration remain challenging as things stand. RESULTS: The status quo with respect to standardization initiatives is summarized here, with particular emphasis on the motivation for, and the challenges of, ongoing synergistic activities amongst the academic community focused on the creation of truly interoperable standards. …”
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    Towards Interoperable Reporting Standards for Omics Data: Hopes and Hurdles
  4. 1244
    “…Several solutions have been proposed to meet the expectations and novel methods have been developed to address the persisting problems of data integration. It is important for researchers to understand different technologies and approaches. …”
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    Current Trends and New Challenges of Databases and Web Applications for Systems Driven Biological Research
  5. 1245
    “…This article presents an overview of the database and the data integration process. We also lay out the key future directions of neXtProt that we consider the necessary steps to make neXtProt the one-stop-shop for all research projects focusing on human proteins.…”
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    neXtProt: a knowledge platform for human proteins
  6. 1246
    por Wu, Cathy, Nebert, Daniel W
    Publicado 2004
    “…The PIRSF (SuperFamily) classification system is central to the PIR/UniProt functional annotation of proteins, providing classifications of whole proteins into a network structure to reflect their evolutionary relationships. Data integration and associative studies of protein family, function and structure are supported by the iProClass database, which offers value-added descriptions of all UniProt proteins with highly informative links to more than 50 other databases. …”
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    Update on genome completion and annotations: Protein Information Resource
  7. 1247
    “…The system was unusual in that it addressed the needs of a widely distributed, voluntary, community engaged in real-time data integration to support operational public health.…”
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    Technical Description of the Distribute Project: A Community-based Syndromic Surveillance System Implementation
  8. 1248
    “…The application code was released into the open source community in January 2012, with 32 instances in operation. tranSMART’s extensible data model and corresponding data integration processes, rapid data analysis features, and open source nature make it an indispensable tool in translational or clinical research.…”
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    tranSMART: An Open Source Knowledge Management and High Content Data Analytics Platform
  9. 1249
    por Spies, Daniel, Ciaudo, Constance
    Publicado 2015
    “…Furthermore, possible improvements in analysis, data integration as well as future applications of differential expression analysis are discussed.…”
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    Dynamics in Transcriptomics: Advancements in RNA-seq Time Course and Downstream Analysis
  10. 1250
    por Tan, Ge, Lenhard, Boris
    Publicado 2016
    “…The functionality of the package can be easily extended to include advanced statistical analysis, data visualization and data integration. Availability and implementation: The package is implemented in R and available under GPL-2 license from the Bioconductor website (http://bioconductor.org/packages/TFBSTools/). …”
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    TFBSTools: an R/bioconductor package for transcription factor binding site analysis
  11. 1251
    “…From its outset – when P(3)G first tackled the building of biobanks as resources as well as data cataloguing and harmonization for data integration – to its new mission and vision, it has continually developed the tools for the conceptualization and design of population biobanks from their inception to their use to their closure. …”
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    P(3)G — 10 years of toolbuilding: From the population biobank to the clinic
  12. 1252
    “…Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. …”
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    FRED 2: an immunoinformatics framework for Python
  13. 1253
    “…Microarray platform integration can be conceptually divided into approaches that perform early stage integration (cross-platform normalization) versus late stage data integration (meta-analysis). A growing number of statistical methods and associated software for platform integration are available to the user, however an understanding of their comparative performance and potential pitfalls is critical for best implementation. …”
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    Microarray Meta-Analysis and Cross-Platform Normalization: Integrative Genomics for Robust Biomarker Discovery
  14. 1254
    “…In Ensembl, we substantially solve this problem: we develop methods to facilitate data integration and broad access; aggregate information in a consistent manner and make it available a variety of standard formats, both visually and programmatically; build analysis pipelines to compare variants to comprehensive genomic annotation sets; and make all tools and data publicly available.…”
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    Ensembl variation resources
  15. 1255
    “…Improvements in the sensitivity, content, and throughput of microscopy, in the depth and throughput of single-cell sequencing approaches, and in computational and modeling tools for data integration have created a portfolio of methods for building spatiotemporal cell atlases. …”
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    Spatial and temporal tools for building a human cell atlas
  16. 1256
    “…A unified formal characterization of these uncertainties through probabilistic approaches and ensemble modeling will facilitate convergence towards consistent reconstruction pipelines, improved data integration algorithms, and more accurate assessment of predictive capacity. …”
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    Addressing uncertainty in genome-scale metabolic model reconstruction and analysis
  17. 1257
    “…Combining evidence from multiple data sources presents significant challenges, but discussions around this subject often confuse issues of data access and privacy, with the actual technical challenges of data integration and interoperability. We review some of the opportunities for connecting data, generating information, and supporting decision-making across the increasingly complex “variety” dimension of data in population health, to enable data-driven surveillance to go beyond simple signal detection and support an expanded set of surveillance goals.…”
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    Data-Driven Surveillance: Effective Collection, Integration, and Interpretation of Data to Support Decision Making
  18. 1258
    por Lester, Robert M.
    Publicado 2021
    “…The intent of this review is to summarize the new US Food and Drug Administration (FDA) Question and Answer update from August 2020 and key messaging from a subsequent FDA webinar describing best practices for preclinical and clinical data integration into a QT risk prediction model.…”
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    Update on ICH E14/S7B Cardiac Safety Regulations: The Expanded Role of Preclinical Assays and the “Double‐Negative” Scenario
  19. 1259
    “…We propose a reference-independent solution, which exploits the synergistic effects of multi-omic data integration for the in situ study of microbiomes using long-read sequencing data.…”
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    Functional meta-omics provide critical insights into long- and short-read assemblies
  20. 1260
    “…Analysis at the transcript level allows data integration with scATAC-seq on individual promoters, improved correlation with protein expression data, and linked mutations known to confer drug resistance to transcriptome heterogeneity. …”
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    Comprehensive characterization of single-cell full-length isoforms in human and mouse with long-read sequencing
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