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  1. 1481
    “…Here, we show that protection in both study arms was associated with early induction of functional IL-21-secreting circumsporozoite (CSP)-specific pTfh cells, together with induction of CSP-specific memory B cell responses after the second dose that persisted after the third dose. Data integration of key immunologic measures identified a subset of non-protected individuals in the standard (STD) vaccine arm who lost prior protective B cell responses after receiving the third vaccine dose. …”
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    A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses
  2. 1482
    “…Collectively, our results demonstrate that TFSEE is a robust enhancer-calling algorithm that can be used to perform multilayer genomic data integration to uncover cell type-specific TFs that control lineage-specific enhancers.…”
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    Total Functional Score of Enhancer Elements Identifies Lineage-Specific Enhancers That Drive Differentiation of Pancreatic Cells
  3. 1483
    “…Our results demonstrate that data integration through topological techniques can increase our ability to identify previously unreported cancer-related alterations.…”
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    Identification of relevant genetic alterations in cancer using topological data analysis
  4. 1484
    “…Douarnenez fish. The data integration allowed to hypothesize relationships between membrane phospholipids, xenobiotic metabolism, bioenergetics, and antioxidant defence. …”
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    An Integrated Biomarker Approach Using Flounder to Improve Chemical Risk Assessments in the Heavily Polluted Seine Estuary
  5. 1485
    por Kamdar, Maulik R., Musen, Mark A.
    Publicado 2021
    “…We observe that several LSLOD sources exist as stand-alone data sources that are not inter-linked with other sources, use unpublished schemas with minimal reuse or mappings, and have elements that are not useful for data integration from a biomedical perspective. We envision that the LSLOD schema graph and the findings from this research will aid researchers who wish to query and integrate data and knowledge from multiple biomedical sources simultaneously on the Web.…”
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    An empirical meta-analysis of the life sciences linked open data on the web
  6. 1486
    “…To account for a relatively low consistency observed for certain data modalities, we developed a robust data integration approach that identifies reproducible signals shared among multiple data modalities and studies. …”
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    Multi‐modal meta‐analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
  7. 1487
    por Maki, Masayuki, Kim, Yura
    Publicado 2021
    “…The original raw radar data are available from the “XRAIN Precipitation Original Data search and Download System”, which is hosted on the website “Data Integration and Analysis System (DIAS)”. Animated images of the radar data shown here, which provide a visual explanation of the temporal evolution and the inner structure of volcanic eruption clouds, were created using the program “Analysis Tools of Three-dimensional Weather Radar Data (AN3D)”. …”
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    Visualizing weather radar data from volcanic eruption clouds
  8. 1488
    “…This raises the question of data integration methods and tools. These approaches allow us to increase our knowledge on immune mechanisms as well as the identification of key effectors of the immune response. …”
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    Strategies for Immunomonitoring after Vaccination and during Infection
  9. 1489
    “…Furthermore, we develop a computational workflow (SCeptre) that effectively normalizes the data, integrates available FACS data and facilitates downstream analysis. …”
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    Quantitative single-cell proteomics as a tool to characterize cellular hierarchies
  10. 1490
    “…In turn, this increases data interoperability and enables data integration.…”
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    Ten simple rules for making a vocabulary FAIR
  11. 1491
    “…AdipoAtlas reference lipidome serves as a data-rich resource for the development of WAT-specific high-throughput methods and as a scaffold for systems medicine data integration.…”
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    AdipoAtlas: A reference lipidome for human white adipose tissue
  12. 1492
    “…These findings open up new venues to apply network-based tools for cross-scale data integration.…”
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    Network analysis reveals rare disease signatures across multiple levels of biological organization
  13. 1493
    por Oh, Sooyoun, Park, Haesun, Zhang, Xiuwei
    Publicado 2021
    “…Technologies that measure multiple modalities of such data add more detail, but they also complicate data integration. We offer an integrated analysis of the spatial location and gene expression profiles of cells to determine their identity. …”
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    Hybrid Clustering of Single-Cell Gene Expression and Spatial Information via Integrated NMF and K-Means
  14. 1494
    “…A “systemic storm” pattern with release of 1,061 markers, together with a pattern suggestive of the “massive consumption” of 892 constitutive circulating markers, is identified in the acute phase post-trauma. Data integration reveals two human injury response endotypes, which align with clinical trajectory. …”
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    Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses
  15. 1495
    “…The DO, funded as a NHGRI Genomic Resource, plays a key role in disease knowledge organization, representation, and standardization, serving as a reference framework for multiscale biomedical data integration and analysis across thousands of clinical, biomedical and computational research projects and genomic resources around the world. …”
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    The Human Disease Ontology 2022 update
  16. 1496
    “…Secondly, we employ data integration to merge information from: (i) SNV density; (ii) SNVs in driver genes and (iii) trinucleotide motifs. …”
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    Cancer Type Classification in Liquid Biopsies Based on Sparse Mutational Profiles Enabled through Data Augmentation and Integration
  17. 1497
    por Waspe, Jennifer, Beronius, Anna
    Publicado 2022
    “…Adverse Outcome Pathways (AOPs) are a research synthesis tool, used primarily by toxicologists for numerous applications including: hypothesis generation, data integration, biomarker determination, and identification of gaps in current knowledge. …”
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    Development of an adverse outcome pathway for intrahepatic cholestasis of pregnancy
  18. 1498
    “…Exploring the multiomics perspective and the concurrent data integration may provide new suitable therapeutic solutions to combat the COVID-19 pandemic.…”
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    COVIDomics: The Proteomic and Metabolomic Signatures of COVID-19
  19. 1499
    “…Expanding on this, our review initially focuses on the recent computational strategies aiming at investigating protein–protein interfaces in a dynamic fashion using enhanced sampling, multi-scale modeling, and experimental data integration. Then, we discuss how interface dynamics report on the function of protein assemblies in globular complexes, in fuzzy complexes containing intrinsically disordered proteins, as well as in active complexes, where chemical reactions take place across the protein–protein interface.…”
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    Modeling the Dynamics of Protein–Protein Interfaces, How and Why?
  20. 1500
    “…Furthermore, we show that crossmodal generation by scMM leads to more precise prediction and data integration compared with the state-of-the-art and conventional approaches.…”
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    A mixture-of-experts deep generative model for integrated analysis of single-cell multiomics data
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