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  1. 1681
    “…To facilitate discovery, we have added new views of the data, integrated large-scale datasets and expanded descriptions of models for human disease. …”
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    WormBase 2012: more genomes, more data, new website
  2. 1682
    “…The SPUS can process standard Moderate Resolution Imaging Spectroradiometer (MODIS L1B) data integrated with a Pattern Decomposition Method (PDM) and an LULC-Conversion Model to obtain patterns of land use and land cover, and provide input parameters for a Population Spatialization Model (PSM). …”
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    An Updating System for the Gridded Population Database of China Based on Remote Sensing, GIS and Spatial Database Technologies
  3. 1683
    “…Document-processing and data integration software combines data from the database with a template to generate topic- and country-specific Calculator documents for quantitative analysis. …”
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    A Toolkit to assess health needs for congenital disorders in low- and middle-income countries: an instrument for public health action
  4. 1684
    “…The exercise groups in the identified trials were categorized according to their type, frequency, and duration of exercise, and subgroup analyses were performed. [Results] Data integration of 17 studies (23 exercise groups) revealed a significant effect and a medium effect size. …”
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    Effect of the Frequency and Duration of Land-based Therapeutic Exercise on Pain Relief for People with Knee Osteoarthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
  5. 1685
    “…The maps, based on meta-omics approaches, may be considered as new tools, acting as a systems biology-based proof of evidence to evaluate MD effects on gut microbiota homeostasis. Data integration of food metabotypes and gut microbiota “enterotypes” may allow one to interpret MD adherence and its effects on health in a new way, employable for the design of targeted diets and nutraceutical interventions in childcare and clinical management of food-related diseases, whose onset has been significantly shifted early in life.…”
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    Mediterranean Diet and Health: Food Effects on Gut Microbiota and Disease Control
  6. 1686
    “…In this paper, we review the features of publically available bio and health cloud systems in terms of graphical user interface, external data integration, security and extensibility of features. …”
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    Bio and health informatics meets cloud : BioVLab as an example
  7. 1687
    “…Next, the development and application of a novel data integration methodology reveals novel functions of RND3 in controlling glioma cell migration, invasion, proliferation, angiogenesis and clinical outcome.…”
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    Inference of Low and High-Grade Glioma Gene Regulatory Networks Delineates the Role of Rnd3 in Establishing Multiple Hallmarks of Cancer
  8. 1688
    “…Here, we present a tool, variant analysis of sequenced pedigrees (VASP), a flexible data integration environment capable of producing a summary of pedigree variation, providing relevant information such as compound heterozygosity, genome phasing and disease inheritance patterns. …”
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    Reducing the search space for causal genetic variants with VASP
  9. 1689
    “…Nanopublications can have a leading role into hypotheses generation offering opportunities to produce large-scale data integration. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2041-1480-6-5) contains supplementary material, which is available to authorized users.…”
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    Nanopublications for exposing experimental data in the life-sciences: a Huntington’s Disease case study
  10. 1690
    “…To overcome limitations of conventional light-microscopic analysis, we used high resolution Raman microspectral imaging to identify structural and compositional alterations in enamel and dentine that coincided with elemental signatures and with detailed medical and behavioural data. Integrating these objective biochemical markers with temporal mapping of teeth enables the retrospective study of early life developmental disruptions and their ensuing health sequelae.…”
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    Uncovering system-specific stress signatures in primate teeth with multimodal imaging
  11. 1691
    “…Third, using the genome as a common reference, proBAMsuite facilitates seamless proteomics and proteogenomics data integration. Finally, proBAM files can be readily visualized in genome browsers and thus bring proteomics data analysis to a general audience beyond the proteomics community. …”
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    proBAMsuite, a Bioinformatics Framework for Genome-Based Representation and Analysis of Proteomics Data
  12. 1692
    “…The visualization and interpretation of the results are facilitated by an automated post-processing pipeline based on topological analysis and data integration about the predicted complex proteins. …”
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    Pepper: cytoscape app for protein complex expansion using protein–protein interaction networks
  13. 1693
    “…Furthermore, bioinformatics has enabled comprehensive multi-omics and clinical data integration for insightful interpretation. Despite their promise, the translation of these technologies into clinically actionable tools has been slow. …”
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    Omics-Based Strategies in Precision Medicine: Toward a Paradigm Shift in Inborn Errors of Metabolism Investigations
  14. 1694
    “…METHODS: To achieve the retrospective cohort study, we integrated existing clinical databases from different Bejaia department health sector institutions (an Algerian department) to collect information about patients from January 2015 through December 2015. Data integration was performed in a data warehouse using the multi-dimensional model and OLAP cube. …”
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    Decision support system for health care resources allocation
  15. 1695
    “…To provide a central access point for these purposes, the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods developed the Integrated Chemical Environment (ICE) web resource. The ICE data integrator allows users to retrieve and combine data sets and to develop hypotheses through data exploration. …”
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    An Integrated Chemical Environment to Support 21st-Century Toxicology
  16. 1696
    “…Stagnation in hospitals’ adoption of data integration functionalities coupled with reduction in the number of operational health information exchanges could become a significant impediment to hospitals’ adoption of 3 critical capabilities: electronic health information exchange, interoperability, and medication reconciliation, in which electronic systems are used to assist with resolving medication discrepancies and improving patient safety. …”
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    An observational study of the relationship between meaningful use-based electronic health information exchange, interoperability, and medication reconciliation capabilities
  17. 1697
    “…In addition to delivering the core database and services, Europe PMC focuses on three areas of development: individual user services, data integration, and infrastructure to support text and data mining. …”
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    Europe PMC in 2017
  18. 1698
    “…BACKGROUND: Multilevel data integration is becoming a major area of research in systems biology. …”
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    A computational framework for complex disease stratification from multiple large-scale datasets
  19. 1699
    “…Specifically, we have statistically demonstrated that Fenton reactions take place in cancer cytosol and mitochondria across all the 14 cancer types, based on cancer tissue gene-expression data integrated via the Michaelis–Menten equation. In addition, we have shown that (i) Fenton reactions in cytosol of the disease cells will continuously increase their pH, to which the cells respond by generating net protons to keep the pH stable through a combination of synthesizing glycolytic ATPs and consuming them by nucleotide syntheses, which may drive cell division to rid of the continuously synthesized nucleotides; and (ii) Fenton reactions in mitochondria give rise to novel ways for ATP synthesis with electrons ultimately coming from H(2)O(2), largely originated from immune cells. …”
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    Fenton reactions drive nucleotide and ATP syntheses in cancer
  20. 1700
    “…Also, it performs the functional characterization of the prophages regions through data integration of biological databases. The performance of PhageWeb was compared to other available tools (PHASTER, Prophinder, and PhiSpy) using Sensitivity (Sn) and Positive Predictive Value (PPV) tests. …”
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    PhageWeb – Web Interface for Rapid Identification and Characterization of Prophages in Bacterial Genomes
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