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  1. 1961
    por Buxton, Richard B.
    Publicado 2010
    “…The importance of developing a solid theoretical framework is emphasized, both as an essential tool for analyzing oxygenation-based multimodal measurements, and also potentially as a way to better understand the physiological phenomena themselves. The existing data, integrated within a simple theoretical framework of O(2) transport, suggests the hypothesis that an important functional role of the mismatch of CBF and CMRO(2) changes with neural activation is to prevent a fall of tissue pO(2). …”
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    Interpreting Oxygenation-Based Neuroimaging Signals: The Importance and the Challenge of Understanding Brain Oxygen Metabolism
  2. 1962
    “…BACKGROUND: Researchers in biomedical informatics use ontologies and terminologies to annotate their data in order to facilitate data integration and translational discoveries. As the use of ontologies for annotation of biomedical datasets has risen, a common challenge is to identify ontologies that are best suited to annotating specific datasets. …”
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    Building a biomedical ontology recommender web service
  3. 1963
    “…RESULTS: Here we present rule-based mediation, a method of semantic data integration applied to systems biology model annotation. …”
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    Annotation of SBML models through rule-based semantic integration
  4. 1964
    “…The classical problems of gathering meaningful data, fitting specific models, and discovering appropriate analysis and visualization tools give way to a new class of computational challenges—management of large and incongruous data, integration and interoperability of computational resources, and data provenance. …”
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    Neuroimaging Study Designs, Computational Analyses and Data Provenance Using the LONI Pipeline
  5. 1965
    “…Furthermore, iSyn669 was used as a transcriptomic data integration scaffold and thereby we found metabolic hot-spots around which gene regulation is dominant during light-shifting growth regimes. …”
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    Reconstruction and analysis of genome-scale metabolic model of a photosynthetic bacterium
  6. 1966
    “…Systematic application of data integration methods is also hampered by a multitude of such factors as the orthogonal nature of the integrated data and naming problems. …”
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    BiologicalNetworks 2.0 - an integrative view of genome biology data
  7. 1967
    “…RESULTS: We report the genome-wide mRNA signature of adult testes lacking Sox9 in Sertoli cells before and after the onset of late spermatogenic failure as compared to fertile controls. The GeneChip data integrated with evolutionarily conserved Sox9 DNA binding motifs and regulatory network data identified genes involved in feminization, stress response and inflammation. …”
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    Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress
  8. 1968
    “…BACKGROUND: In the contexts of genomics, post-genomics and systems biology approaches, data integration presents a major concern. Databases provide crucial solutions: they store, organize and allow information to be queried, they enhance the visibility of newly produced data by comparing them with previously published results, and facilitate the exploration and development of both existing hypotheses and new ideas. …”
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    Exploration of plant genomes in the FLAGdb(++ )environment
  9. 1969
    “…During this information revolution, the data-gathering capabilities have greatly surpassed the data-analysis techniques. Data integration across heterogeneous data sources and data aggregation across different aspects of the biomedical spectrum, therefore, is at the centre of current biomedical and pharmaceutical R&D. …”
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    Online Artículo Texto
    Developing a European grid infrastructure for cancer research: vision, architecture and services
  10. 1970
    “…Because the data and expertise associated with this field is both sparse and disparate, significant benefits will potentially accrue from the availability of an ontology that provides a shared conceptualisation of the domain knowledge and enables data integration, cross-referencing and advanced reasoning across the relevant but distributed data sources. …”
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    The Bone Dysplasia Ontology: integrating genotype and phenotype information in the skeletal dysplasia domain
  11. 1971
    “…Exemplary datasets are discussed to validate the approach, which illustrate how initial hypotheses can be generated from the consortium-produced metabolomics data, integrated with prior knowledge to provide a testable hypothesis concerning the functionality of GUFs.…”
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    Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of “Unknown Function”
  12. 1972
    por Thomas, Laurent F., Sætrom, Pål
    Publicado 2012
    “…To test this hypothesis, we identified single nucleotide polymorphisms (SNPs) that can create or disrupt APA signals (APA-SNPs). By using a data-integrative approach, we show that APA-SNPs can affect 3′UTR length, miRNA regulation, and mRNA expression—both between homozygote individuals and within heterozygote individuals. …”
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    Single Nucleotide Polymorphisms Can Create Alternative Polyadenylation Signals and Affect Gene Expression through Loss of MicroRNA-Regulation
  13. 1973
    “…OPL is primarily designed to serve as a reference ontology for parasite life cycle stages that can be used for database annotation purposes and in the lab for data integration or information retrieval as exemplified in the application section below. …”
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    The Ontology for Parasite Lifecycle (OPL): towards a consistent vocabulary of lifecycle stages in parasitic organisms
  14. 1974
    por Lopes, Pedro, Oliveira, José Luís
    Publicado 2012
    “…The framework provides a single package including advanced data integration and triplification tools, base ontologies, a web-oriented engine and a flexible exploration API. …”
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    COEUS: “semantic web in a box” for biomedical applications
  15. 1975
    “…We demonstrate that the cross-link validation and visualization software Xwalk facilitates successful cross-link data integration. Besides the protocols we introduce XLdb, a database of chemical cross-links from 14 different publications with 506 intra-protein and 62 inter-protein cross-links, where each cross-link can be mapped on an experimental structure from the Protein Data Bank. …”
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    Cross-Link Guided Molecular Modeling with ROSETTA
  16. 1976
    “…As we look forward to a future that embraces open access to data and publications, it is essential that data policies, data curation, data integration, data infrastructure, and data funding are linked together so as to foster data access and research productivity.…”
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    Making open data work for plant scientists
  17. 1977
    “…This study also checked if the data management system plays a sufficient role as a bridge between the point-of-care testing equipment and the hospital information system through connection persistence and reliability testing, as well as data integration and interoperability testing. RESULTS: In comparison with the existing system, the data management system facilitated integration by improving the result receiving time, improving the collection rate, and by enabling the integration of disparate types of data into a single system. …”
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    Design and Realization of Integrated Management System for Data Interoperability between Point-of-Care Testing Equipment and Hospital Information System
  18. 1978
    por Vihinen, Mauno
    Publicado 2014
    “…BACKGROUND: Systematic representation of information related to genetic and non-genetic variations is required to allow large scale studies, data mining and data integration, and to make it possible to reveal novel relationships between genotype and phenotype. …”
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    Variation ontology: annotator guide
  19. 1979
    “…Here, we describe our recent progress in spatial mapping and data integration. EMAGE has developed a method of spatially mapping 3D embryo images captured using optical projection tomography, and through the use of an IIP3D viewer allows users to view arbitrary sections of raw and mapped 3D image data in the context of a web browser. …”
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    EMAGE mouse embryo spatial gene expression database: 2014 update
  20. 1980
    “…BACKGROUND: We present Pegasys – a flexible, modular and customizable software system that facilitates the execution and data integration from heterogeneous biological sequence analysis tools. …”
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    Pegasys: software for executing and integrating analyses of biological sequences
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