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255901por Valcourt, Emelissa J., Manguiat, Kathy, Robinson, Alyssia, Lin, Yi-Chan, Abe, Kento T., Mubareka, Samira, Shigayeva, Altynay, Zhong, Zoë, Girardin, Roxie C., DuPuis, Alan, Payne, Anne, McDonough, Kathleen, Wang, Zhen, Gasser, Romain, Laumaea, Annemarie, Benlarbi, Mehdi, Richard, Jonathan, Prévost, Jérémie, Anand, Sai Priya, Dimitrova, Kristina, Phillipson, Clark, Evans, David H., McGeer, Allison, Gingras, Anne-Claude, Liang, Chen, Petric, Martin, Sekirov, Inna, Morshed, Muhammad, Finzi, Andrés, Drebot, Michael, Wood, Heidi“…IMPORTANCE SARS-CoV-2, the causal agent of COVID-19, has infected over 246 million people and led to over 5 million deaths as of October 2021. With the approval of several efficacious COVID-19 vaccines, methods to evaluate protective immune responses will be crucial for the understanding of long-term immunity in the rapidly growing vaccinated population. …”
Publicado 2021
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255902por Moskovitz, Joshua B., Tan, Timothy, Dilip, Monisha, Khambhati, Kaushal, Smith, Colleen, Sapadin, Joshua, Dauer, Morgan, Chin, Robert, Hammock, Regina, Leno, Richard, Kessler, Stuart, Wei, Eric, Silvestri, David, Natsui, Shaw“…Of 2302 patients discharged from the FTA, 182 (7.9%) returned to the ED within 7 days, resulting in 42 (1.8%) hospitalizations and 7 (0.3%) deaths. Facilities using EMR‐MSE discharged more patients from their FTA (81.9% vs 65.3%, P < 0.001) and had similar 7‐day return (9.3% vs 7.1%, P = 0.055) and mortality rates (0.49% vs 0.20%, P = 0.251). …”
Publicado 2021
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255903por Takeda, Yohei, Jamsransuren, Dulamjav, Nagao, Tomokazu, Fukui, Yoko, Matsuda, Sachiko, Ogawa, Haruko“…IMPORTANCE The COVID-19 pandemic has caused an unprecedented number of infections and deaths. As the spread of the disease is rapid and the risk of infection is severe, hand and environmental hygiene may contribute to suppressing contact transmission of SARS-CoV-2. …”
Publicado 2021
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255904por Teng, Thomas Zheng Jie, Tan, Jun Kiat Thaddaeus, Baey, Samantha, Gunasekaran, Sivaraj K, Junnarkar, Sameer P, Low, Jee Keem, Huey, Cheong Wei Terence, Shelat, Vishal G“…Gallstones (n = 404, 61.9%), alcohol (n = 38, 5.8%), and hypertriglyceridemia (n = 19, 2.9%) were more common aetiologies. 81 (12.4%) patients developed SAP, 20 (3.1%) required ICU admission, and 12 (1.8%) deaths were attributed to SAP. Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP (92.6%, 80.2% respectively), ICU admission (100%), and mortality (100%). …”
Publicado 2021
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255905“…Gastric cancer (GC), as an epidemic cancer worldwide, has more than 1 million new cases and an estimated 769,000 deaths worldwide in 2020, ranking fifth and fourth in global morbidity and mortality. …”
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255906por Wyper, Grant M A, Fletcher, Eilidh, Grant, Ian, Harding, Oliver, de Haro Moro, Maria Teresa, Stockton, Diane L, McCartney, Gerry“…METHODS: DALYs were estimated with an international consensus model with Scottish national deaths and daily cases as data inputs. Health loss valuation was defined with the aspirational reference life table and disability weights from the Global Burden of Disease Study 2019. …”
Publicado 2021
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255907“…Sufficiently granular data on deaths were not available to investigate excess mortality. …”
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255908por Sakai, Fumihiko, Suzuki, Norihiro, Ning, Xiaoping, Ishida, Miki, Usuki, Chiharu, Iba, Katsuhiro, Isogai, Yuki, Koga, Nobuyuki“…The discontinuation rate was low (4.0% from adverse events, 2.0% from a lack of efficacy) and no deaths were reported. The incidence of anti-drug antibody development was low (2.4%). …”
Publicado 2021
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255909por Uka, Anita, Buettcher, Michael, Bernhard-Stirnemann, Sara, Fougère, Yves, Moussaoui, Dehlia, Kottanattu, Lisa, Wagner, Noémie, Zimmermann, Petra, Ritz, Nicole“…Complications were reported in 28 (4.1%) children with cardiovascular complications being most frequent (12 [1.8%]). Three deaths were recorded. Conclusion: This study confirms that COVID-19 is mostly a mild disease in children. …”
Publicado 2021
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255910por Zhang, Zhenyang, Hong, Zhi-Nuan, Xie, Shuhan, Lin, Wenwei, Lin, Yukang, Zhu, Jiafu, Yang, Xiaojie, Lin, Zhiwei, Lin, Jiangbo, Kang, Mingqiang“…There was no treatment- or surgery-related deaths. CONCLUSIONS: Neoadjuvant sintilimab plus chemotherapy for locally advanced ESCC appears to be safe and feasible with limited AEs, high R0 resection rate, promising pCR rate, and manageable postoperative complications. …”
Publicado 2021
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255911por Goswami, Neela, Peddareddy, Lakshmi Praveena, Jereb, John, Semidey, Angel Colon, Darnall, Elaine, Macias, Patricia, Jasuja, Supriya, Landers, Karen, Dasgupta, Shom, Oxtoby, Margaret, Spitters, Christopher, Dov, Lana, Narita, Masa, DaSilva, Malini, Cropper, Tracina, Gullickson, Cricket, Ashkin, David, Haley, Connie“…At 12 months after BPaL initiation, all patients had completed treatment, without TB recurrences or deaths reported. CONCLUSION: In the early period after FDA approval, most U.S. patients received BPaL off-label with an initial linezolid dose lower than the approved 1200mg yet still achieved good outcomes. …”
Publicado 2021
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255912por Mody, Lona, Gibson, Kristen, Bautista, Liza, Neeb, Karen, Montoya, Ana, Jenq, Grace, Mills, John, Min, Lillian, Mantey, Julia, Kabeto, Mohammed, Galecki, Andrzej, Cassone, Marco, Martin, Emily T“…BACKGROUND: The COVID-19 pandemic has disproportionately affected nursing home (NH) patients, accounting for 5% of all cases and 32% of all COVID-19 deaths nationwide. Little is known about the frequency and persistence of SARS-CoV-2 environmental contamination in NHs. …”
Publicado 2021
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255913por Joshi, Seema, Manning, Abigail, Bivins, James, Arshad, Samia, Agbonze, Amen, Berger, Anita M, Czander, Bonnie, Gonzalez, Gonzalo, Heinonen, Jessica H, Klama, Keith, Lamb, Lakita L, Misikir, Helina, Adams, Alexis, Anderson, Micah, Morley, Madelyn, Kilgore, Paul E, Zervos, Marcus, Mossing, Michael, Stylianou, Katerina, Rehman, Najibah K“…BACKGROUND: Nursing home residents, a vulnerable population, experienced an extraordinary surge of COVID-19 cases and deaths at the beginning of the pandemic. Multidisciplinary collaboration from the Detroit Health Department (DHD), academic centers, along with interim guidance from the CDC provided a structured approach to control SARS-CoV-2 in Detroit skilled nursing facilities (SNF). …”
Publicado 2021
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255914por Watkins, Andrew B, Brand, Lisa M, Schwedhelm, Michelle, Jensen, Heather L, Scott, Brandon, German, Dan K, Strand, Kyle P, Kamal-Ahmed, Ishrat, Lawler, James, Salman Ashraf, M“…Debographics and Outcomes of mAb Infusions [Image: see text] CONCLUSION: By utilizing existing relationships with LTCFs in the region, we established a program to promptly distribute, prepare, and administer monoclonal antibody therapy to LTCF residents in need, preventing COVID-related hospitalizations and deaths. DISCLOSURES: James Lawler, MD, MPH, FIDSA, Kinsa Health (Advisor or Review Panel member)Takeda Pharmaceuticals (Advisor or Review Panel member) M. …”
Publicado 2021
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255915por Lehnertz, Nicholas, Bo-Subait, Khalid, Hadsall, Candy, Barber, Cheryl, LaPointe, Allison, Livingston, Cindy Lind, Dippmann, Karmen, Babcock, Marcie, Kendrick, Brian, Griffith, Jayne, Liverseed, Gina, Darrett-Brewer, Peggy, Jones, Christine L“…RESULTS: During 2016-2020, there were 47 CS cases from 45 mothers, peaking in 2020 at a rate of 3.2/10,000 live births. 43 (91.5%) cases of CS had no clinical signs, 1 (2.1%) CS case was inadequately treated, and there were 2 deaths. The median maternal age was 28 (IQR 9, range 18-38). 13 (28.9%) identified as Black, non-Hispanic, 13 (28.9%) as American Indian/Alaska Native (AI/AN), 9 (20.0%) as White, non-Hispanic, 3 (6.7%) as Hispanic, 2 (4.4%) as Asian/Pacific Islander, and 5 (11.1%) Other/Unknown. …”
Publicado 2021
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255916“…There were no SAEs, life-threatening events or deaths throughout the study. IV PLG0206 exhibited linear PK over the dose range of 0.05 to 1.0 mg/kg. …”
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255917por Meyer, Stephanie, Saupe, Amy, Bieringer, Aaron, Holtzman, Corinne, Magnuson, Luke, Bye, Erica, Muscoplat, Miriam, Wang, Xiong, Lorentz, Alexandra, Como-Sabetti, Kathryn, Lynfield, Ruth, Lynfield, Ruth“…BACKGROUND: Over 600,000 COVID-19 cases, including >7000 deaths reported to MN Dept of Health (MDH) by June 1, 2021. …”
Publicado 2021
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255918“…No subjects withdrew due to AEs, and there were no severe AEs, no serious AEs, and no deaths. AEs were of mild (97%) to moderate (3%) intensity and were reported by all subjects in the LSVT-1701 6 mg/kg single dose group and 1-3 (17-50%) of subjects receiving 1.5 to 4.5 mg/kg BID or placebo. …”
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255919por Chamseddine, Sarah, Zaheer, Haniah A, Williams, John V, Martin, Judith M, Rick, Anne-Marie, Liu, Hui“…RESULTS: Among 421 infants with influenza, 134 (32%) were < 6 months (m), 28 (6.5%) were born prematurely (< 35 weeks gestational age), and 41(10%) had chronic medical conditions (CMC). 62 (15%) required hospital admission, 13 (21%) of which required ICU care. No deaths were reported. Secondary bacterial infections were diagnosed in 101 (24%) including acute otitis media (84%), pneumonia (15%) and sinusitis (3%). …”
Publicado 2021
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255920“…BACKGROUND: Due to the ongoing opioid epidemic, PWID represent an increasingly high-risk population for HIV infections in the United States, accounting for 10% of all new HIV diagnoses in 2018 and 12.5% of all deaths among people living with HIV. PrEP is an effective means of preventing HIV, though uptake has been low among PWID, possibly due to low access to care. …”
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