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  1. 256141
    “…Myelosuppression was frequent with 70% and 63% of patients experiencing WHO grade III or IV leukocytopenia and thrombocytopenia, respectively. 6 cases of febrile neutropenia were observed, with 2 treatment-related deaths. Non-haematological toxicity consisted mainly of nausea and vomiting, which was grade III in 22% of patients. …”
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    Accelerated cisplatin and high-dose epirubicin with G-CSF support in patients with relapsed non-small-cell lung cancer: feasibility and efficacy
  2. 256142
    “…Postoperative complications included seven pelvic or wound infections and two anastomotic and two perineal wound dehiscences. There were no deaths in the first 30 days postoperatively. Of 41 resected specimens, 11 (27%) showed a pathological complete response (pCR) and five (12%) showed an involved circumferential resection margin (defined as ⩽1 mm). …”
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    Preoperative downstaging chemoradiation with concurrent irinotecan and capecitabine in MRI-defined locally advanced rectal cancer: a phase I trial (NWCOG-2)
  3. 256143
    “…Early side effects included mainly grade 4 haematologic toxicity (neutropaenia in 79% of patients, thrombocytopaenia in 69%, anaemia in 22%), grade 4 stomatitis (19%), and four early deaths (7% of patients), at least partially related to toxicity. …”
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    Alternating dose-dense chemotherapy in patients with high volume disseminated non-seminomatous germ cell tumours
  4. 256144
    “…This statement of the World Allergy Organization (WAO) raises the importance of this health hazard and highlights the facts on climate-related health impacts, including: deaths and acute morbidity due to heat waves and extreme meteorological events; increased frequency of acute cardio-respiratory events due to higher concentrations of ground level ozone; changes in the frequency of respiratory diseases due to trans-boundary particle pollution; altered spatial and temporal distribution of allergens (pollens, molds, and mites); and some infectious disease vectors. …”
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    Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization
  5. 256145
    por Rúa-Figueroa, Íñigo, Richi, Patricia, López-Longo, Francisco Javier, Galindo, María, Calvo-Alén, Jaime, Olivé-Marqués, Alejandro, Loza-Santamaría, Estíbaliz, Vicente, Sabina Pérez, Erausquin, Celia, Tomero, Eva, Horcada, Loreto, Uriarte, Esther, Sánchez-Atrio, Ana, Rosas, José, Montilla, Carlos, Fernández-Nebro, Antonio, Rodríguez-Gómez, Manuel, Vela, Paloma, Blanco, Ricardo, Freire, Mercedes, Silva, Lucía, Díez-Álvarez, Elvira, Ibáñez-Barceló, Mónica, Zea, Antonio, Narváez, Javier, Martínez-Taboada, Víctor, Marenco, José Luis, de Castro, Mónica Fernández, Fernández-Berrizbeitia, Olaia, Hernández-Beriain, José Ángel, Gantes, Marian, Hernández-Cruz, Blanca, Pérez-Venegas, José J., Pecondón, Ángela, Marras, Carlos, Carreira, Patricia, Bonilla, Gema, Torrente, Vicente, Castellví, Iván, Alegre, Juan, Moreno, Mireia, Raya, Enrique, de la Peña, Paloma García, Vázquez, Tomás, Aguirre, Ángeles, Quevedo, Víctor, Pego-Reigosa, José M.
    Publicado 2015
    “…SLE patients from the RELESSER register do not appear to differ substantially from other Caucasian populations and although activity [median SELENA-SLEDA: 2 (IQ: 0–4)], damage [median SLICC/ACR/DI: 1 (IQ: 0–2)], and severity [median KATZ index: 2 (IQ: 1–3)] scores were low, 1 of every 4 deaths was due to SLE activity. RELESSER represents the largest European SLE registry established to date, providing comprehensive, reliable and updated information on SLE in the southern European population.…”
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    Comprehensive Description of Clinical Characteristics of a Large Systemic Lupus Erythematosus Cohort from the Spanish Rheumatology Society Lupus Registry (RELESSER) With Emphasis on Complete Versus Incomplete Lupus Differences
  6. 256146
    “…BACKGROUND: Built environment and policy interventions are effective strategies for controlling the growing worldwide deaths from physical inactivity-related non-communicable diseases. …”
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    NEWS for Africa: adaptation and reliability of a built environment questionnaire for physical activity in seven African countries
  7. 256147
    “…BACKGROUND: Pneumococcus kills over one million children annually and over 90 % of these deaths occur in low-income countries especially in Sub-Saharan Africa (SSA) where HIV exacerbates the disease burden. …”
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    Understanding pneumococcal serotype 1 biology through population genomic analysis
  8. 256148
    “…These studies include globally 15,762 patients with COPD (1871 deaths and 42,203 person years of follow-up). We used network meta-analysis adapted to multiple score comparison (MSC), following a frequentist two-stage approach; thus, we were able to compare all scores in a single analytical framework accounting for correlations among scores within cohorts. …”
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    Large-scale external validation and comparison of prognostic models: an application to chronic obstructive pulmonary disease
  9. 256149
    “…BACKGROUND: The burden of preterm birth, fetal growth impairment, and associated neonatal deaths disproportionately falls on low- and middle-income countries where modern obstetric tools are not available to date pregnancies and monitor fetal growth accurately. …”
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    INTERGROWTH-21st Gestational Dating and Fetal and Newborn Growth Standards in Peri-Urban Nairobi, Kenya: Quasi-Experimental Implementation Study Protocol
  10. 256150
    “…Stroke mortality is gradually declining, but it remains as high as 30 deaths per 100,000 individuals, with regional disparities. …”
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    Executive Summary of Stroke Statistics in Korea 2018: A Report from the Epidemiology Research Council of the Korean Stroke Society
  11. 256151
    “…Any grade and grade 3–4 drAEs were reported in 124 (32%) and 27 (7%) of pts, respectively, and there were no treatment-related deaths. Any grade irAEs occurred in 76 (20%) of patients, 8% cutaneous, 4% endocrine, 2% hepatic, 5% gastro-intestinal and 1% pulmonary. …”
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    Real-world efficacy and safety of nivolumab in previously-treated metastatic renal cell carcinoma, and association between immune-related adverse events and survival: the Italian expanded access program
  12. 256152
    “…Serious adverse events and deaths occurred with similar frequencies in the two groups. …”
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    LB10. A Randomized, Double-Blind, Placebo-Controlled Efficacy Trial of a Vaccine to Prevent Chronic Hepatitis C Virus Infection in an at-Risk Population
  13. 256153
    “…During a median follow-up of 1198 days (interquartile range 514-1866 days), 55 850 (21.7%) deaths occurred. A positive troponin result (that is, higher than the upper limit of normal) signified a 3.2 higher mortality hazard (95% confidence interval 3.1 to 3.2) over three years. …”
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    Association of troponin level and age with mortality in 250 000 patients: cohort study across five UK acute care centres
  14. 256154
    “…Every year more than 500,000 deaths are attributed to trauma worldwide and severe hemorrhage is present in most of them. …”
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    Platelet-derived- Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock
  15. 256155
    “…No treatment-related deaths occurred. Higher dose levels resulted in higher C(max). …”
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    Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia
  16. 256156
    “…Over 52 weeks, the incidence of confirmed pneumonia was 9.4% (BGF MDI), 3.6% (GFF MDI), 5.7% (BFF MDI), and 2.9% (BUD/FORM DPI); in the 28-week extension period, rates were comparable across groups (range: 2.9–5.7%). Six deaths were reported (0.7–2.2% per group); none were considered treatment-related. …”
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    Long-Term Safety and Efficacy of Budesonide/Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Formulated Using Co-Suspension Delivery Technology in Japanese Patients with COPD
  17. 256157
    “…There were no reports of serious AEs or deaths. Most patients found the sensor comfortable, with no or minimal impact on daily activities. …”
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    Objectively Monitoring Amyotrophic Lateral Sclerosis Patient Symptoms During Clinical Trials With Sensors: Observational Study
  18. 256158
    “…We also found unfavorable fetal and neonatal outcomes associated with oligohydramnios including stillbirths (OR 5.16, 95%CI 2.07, 12.85), neonatal deaths < 28 days (OR 3.18, 95% CI 1.18, 8.57), low birth weight (OR 2.10, 95% CI 1.44, 3.07) and preterm births (OR 2.73, 95%CI 1.76, 4.23). …”
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    Oligohydramnios: a prospective study of fetal, neonatal and maternal outcomes in low-middle income countries
  19. 256159
    “…Among recruited women with birth data, 4/1147 perinatal deaths > 24 weeks gestation occurred in the intervention group (0.34%) and 4/782 in the control group (0.51%), and two uterine ruptures (one per group), a rate of 1:1000. …”
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    OptiBIRTH: a cluster randomised trial of a complex intervention to increase vaginal birth after caesarean section
  20. 256160
    “…BACKGROUND: Globally, cardiovascular diseases (CVDs) have continued to ravage the human existence through the premature deaths of its workforce. Despite this burden, many studies in Nigeria have focused on determining the prevalence of risk factors which alone are insufficient to assess the risk of future cardiovascular events. …”
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    10-year risk for cardiovascular diseases using WHO prediction chart: findings from the civil servants in South-western Nigeria
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