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  1. 256521
    Publicado 2019
    “…FINDINGS: In 2016, there were 330 000 (95% UI 299 000 to 349 000) incident cases of CNS cancer and 227 000 (205 000 to 241 000) deaths globally, and age-standardised incidence rates of CNS cancer increased globally by 17·3% (95% UI 11·4 to 26·9) between 1990 and 2016 (2016 age-standardised incidence rate 4·63 per 100 000 person-years [4·17 to 4·90]). …”
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    Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
  2. 256522
    “…INTRODUCTION: Accelerating progress in reducing child deaths is needed in order to achieve the Sustainable Development Goal child mortality target. …”
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    A mixed method multi-country assessment of barriers to implementing pediatric inpatient care guidelines
  3. 256523
    “…No significant difference in grade 3–4 diarrhea and no treatment-related deaths were observed in both groups. CONCLUSIONS: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. …”
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    Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer (ESWN 01): a prospective randomized, multicenter, open-labeled phase 3 trial
  4. 256524
    “…There were no venous thromboembolic events, deaths or revisions during the follow-up period in both groups. …”
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    Diabetes mellitus does not negatively impact outcomes and satisfaction following unicompartmental knee arthroplasty in well-controlled disease
  5. 256525
    “…BACKGROUND: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer associated deaths worldwide. Independent studies have proposed altered DNA methylation pattern and aberrant microRNA (miRNA) levels leading to abnormal expression of different genes as important regulators of disease onset and progression in HCC. …”
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    Systems biology based meth-miRNA–mRNA regulatory network identifies metabolic imbalance and hyperactive cell cycle signaling involved in hepatocellular carcinoma onset and progression
  6. 256526
    “…Through 12 weeks post-vaccination, seven patients (6.6%) reported injection-site events. There were no deaths during the substudy, and three patients experienced a serious adverse event. …”
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    Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy
  7. 256527
    “…BACKGROUND: Colorectal cancer (CRC) is one of the main causes of cancer-related deaths in China and around the world. Advanced CRC (ACRC) patients suffer from a low cure rate though treated with targeted therapies. …”
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    Predictive and prognostic implications of 4E-BP1, Beclin-1, and LC3 for cetuximab treatment combined with chemotherapy in advanced colorectal cancer with wild-type KRAS: Analysis from real-world data
  8. 256528
    “…IMPORTANCE: Deaths from cancer are attributed more to secondary than primary tumors, but the pathogenesis of organ-specific cancer metastasis has not been determined. …”
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    Association of Bone Metastasis With Early-Stage Breast Cancer in Women With and Without Precancer Osteoporosis According to Osteoporosis Therapy Status
  9. 256529
    por Bendtsen, Marcus, McCambridge, Jim
    Publicado 2019
    “…BACKGROUND: Harmful use of alcohol continues to be a leading contributor to premature deaths globally. Not only does harmful drinking have consequences for the individuals consuming at increased levels, but it may also result in a range of negative consequences for their family members and friends. …”
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    Reducing Alcohol Consumption Among Risky Drinkers in the General Population of Sweden Using an Interactive Mobile Health Intervention: Protocol for a Randomized Controlled Trial
  10. 256530
    “…On follow-up, 13% of patients had persistent/recurrent disease and 3% cancer-related deaths. Genetic alterations were identified in 54% of HCC, 221 single-nucleotide variants (SNV) and 6 insertions/deletions. …”
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    SAT-567 Mutational Profile of Hurthle Cell Carcinomas: Recurrent Mutations in Wnt/β-catenin Pathway Genes
  11. 256531
    “…IMPORTANCE: Mortality among African children hospitalized with severe malnutrition remains high, with sudden, unexpected deaths leading to speculation about potential cardiac causes. …”
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    Assessment of Myocardial Function in Kenyan Children With Severe, Acute Malnutrition: The Cardiac Physiology in Malnutrition (CAPMAL) Study
  12. 256532
    “…Gastric cancer (GC) is the one of the most prevalent cancers and one of the leading causes of cancer-induced deaths. Previously, we found that the expression of purinergic P2Y(2) receptor (P2Y(2)R) is increased in GC samples as compared to adjacent healthy mucosa taken from GC-diagnosed patients. …”
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    Differential Effects of Purinergic Signaling in Gastric Cancer-Derived Cells Through P2Y and P2X Receptors
  13. 256533
    “…BACKGROUND: Most tuberculosis-related deaths in people with HIV could be prevented with earlier diagnosis and treatment. …”
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    Novel lipoarabinomannan point-of-care tuberculosis test for people with HIV: a diagnostic accuracy study
  14. 256534
    “…The fracture causes severe pain, impedes respiratory function, lower the quality of life, and increases the risk of new fractures and deaths. Various medications have been prescribed to prevent a secondary fracture, but few study summarized their effects. …”
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    Effect of medications on prevention of secondary osteoporotic vertebral compression fracture, non-vertebral fracture, and discontinuation due to adverse events: a meta-analysis of randomized controlled trials
  15. 256535
    “…All pigs with MHD suffered sudden deaths. Control animals were euthanized without being bled prior to necropsy and sampling. …”
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    A descriptive report of the selenium distribution in tissues from pigs with mulberry heart disease (MHD)
  16. 256536
    “…Follow-up ranged from 1 to 81 mo. No cancer-related deaths were observed. Complication rate was extremely low (mostly < 10%). …”
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    Systematic review of ablative therapy for the treatment of renal allograft neoplasms
  17. 256537
    “…No LEF outpatient had an SAE or was admitted during the study, compared with 5 (3%) SAEs, including 2 deaths, in the MOX group. CONCLUSION: These study data suggest that PORT Risk Class III or IV patients can be effectively managed as outpatients with 5 days of oral LEF as an alternative to fluoroquinolones for the treatment of CABP. …”
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    2245. Oral 5-Day Lefamulin for Outpatient Management of Pneumonia Outcomes Research Team (PORT) Risk Class III/IV Community-Acquired Bacterial Pneumonia (CABP): Post Hoc Analysis of the Lefamulin Evaluation Against Pneumonia (LEAP) 2 Phase 3 Study
  18. 256538
    por Pandya, Dhyanesh, Kannangara, Don
    Publicado 2019
    “…Twenty-five were polymicrobial infections. There were 4 deaths, three attributable to SI infection. All isolates tested (32) were susceptible to penicillin (MIC 0.008–0.125 μg/mL), ceftriaxone (MIC = 0.032–0.125 μg/mL) and vancomycin (MIC 0.38–1.0 μg/mL). …”
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    176. Streptococcus intermedius: A Study of 107 Isolates
  19. 256539
    “…RESULTS: There were 206 deaths (114 from breast cancer) after a median follow-up time of 6.0 years after the 2009 interview. …”
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    Pre- to postdiagnosis leisure-time physical activity and prognosis in postmenopausal breast cancer survivors
  20. 256540
    “…Cardiovascular diseases especially AMI are the leading cause of morbidity and mortality in post-renal transplant patients.(1,4) They account for up to 50% of the deaths in RTR. The incidence of AMI in RTR is about 0.2% but it is on the rise. …”
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    Post renal transplant acute myocardial infarction
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