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  1. 256781
    “…Three (1.2%) patients had 12 serious AEs; most were cardiac disorders; all were unrelated to DEX treatment. Two (0.8%) deaths were considered unrelated to treatment. CONCLUSIONS: Based on voluntary reporting of adverse events in this surveillance study, DEX implant for treatment of DME-related visual impairment in the Indian population demonstrated a favorable safety profile with few treatment-related TEAEs (none were considered serious) during the 1-year follow-up. …”
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    Postmarketing safety surveillance of dexamethasone intravitreal implant in the treatment of visual impairment due to diabetic macular edema in India
  2. 256782
    “…BACKGROUND: The surge of methamphetamine use has been a complicating factor compounding the steeply increasing number of drug overdose deaths in the U.S. Infection from blood-borne viruses including hepatitis B virus (HBV), hepatitis C virus (HCV) and HIV, related to methamphetamine use continue to grow. …”
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    Risk factors associated with infection of blood-borne virus among people who used methamphetamine
  3. 256783
    “…The behavioural changes promoted by Care Groups (such as safe infant feeding, frequent hand washing, consistent mosquito net usage, providing suitable complementary foods from 6 months old) have the potential of averting preventable deaths particularly among children under five. While a variety of approaches are used to promote improved health and nutrition for children under five, the Care Groups model was best known and frequently referenced during our discussions with key stakeholders regarding the delivery at community level of Malawi’s National Multi-Sector Nutrition Policy 2018-2022. …”
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    Exploring how and why Care Groups work to improve infant feeding practices in low- and middle-income countries: a realist review protocol
  4. 256784
    “…BACKGROUND: The promotion of contraception in countries with high birth rates has the potential to reduce poverty, hunger, maternal, and childhood deaths. Every year in sub-Saharan Africa approximately 14 million unintended pregnancies occurred and a sizeable proportion was due to poor use of short-term hormonal methods. …”
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    Prevalence and factors associated with early discontinuation rate of Implanon utilization among women who ever used Implanon in Kucha District Gamo Gofa Zone, Southern Ethiopia
  5. 256785
    “…RESULTS: NMR in Burundi in 2010 and 2016 were 36.7 and 25.0 deaths per 1000 live births, respectively. We recorded large wealth-driven (PAR = -3.99, 95% CI; − 5.11, − 2.87, PAF = -15.95, 95% CI; − 20.42, − 11.48), education related (PAF = -6.64, 95% CI; − 13.27, − 0.02), sex based (PAR = -1.74, 95% CI; − 2.27, − 1.21, PAF = -6.97, 95% CI; − 9.09, − 4.86), urban-rural (D = 15.44, 95% CI; 7.59, 23.29, PAF = -38.78, 95% CI; − 45.24, − 32.32) and regional (PAR = -12.60, 95% CI; − 14.30, − 10.90, R = 3.05, 95% CI; 1.30, 4.80) disparity in NMR in both survey years, except that urban-rural disparity was not detected in 2016. …”
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    Time trends, geographical, socio-economic, and gender disparities in neonatal mortality in Burundi: evidence from the demographic and health surveys, 2010–2016
  6. 256786
    “…BACKGROUND: Tuberculosis (TB) is a major human threat, as evidenced by the large numbers of cases and deaths, particularly in developing countries with poor economic and educational statuses. …”
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    Prevalence and determinants of TB infection in a rural population in northeastern Myanmar
  7. 256787
    “…The greatest reduction in survival occurred within the first-year post-fracture, where mortality risk more than doubled and deaths were observed in 1 in 11 women and 1 in 7 men following a non-hip fracture and in 1 in 5 women and 1 in 3 men following a hip fracture. …”
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    Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario
  8. 256788
    “…BACKGROUND: SARS-CoV-2, the virus that caused the global COVID-19 pandemic, has severely impacted Central Asia; in spring 2020, high numbers of cases and deaths were reported in this region. The second wave of the COVID-19 pandemic is currently breaching the borders of Central Asia. …”
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    Surveillance Metrics of SARS-CoV-2 Transmission in Central Asia: Longitudinal Trend Analysis
  9. 256789
    “…Over 25 ± 12 months, 111 HFpEF pts (63%) reached the combined outcome (24 deaths and 87 HF hospitalizations). Diabetes was a significant predictor of mortality and hospitalization for heart failure (HR: 1.72 [1.1–2.6], p = 0.011, adjusted for age, BMI, NYHA class and renal function). …”
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    Diabetic phenotype and prognosis of patients with heart failure and preserved ejection fraction in a real life cohort
  10. 256790
    “…BACKGROUND: Breast cancer is one of the leading causes of cancer-related deaths in women, and there is a demand in developing an Asian-based genetic profiling database for breast cancer in improving the treatment response. …”
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    Comprehensive molecular profiling of Taiwanese breast cancers revealed potential therapeutic targets: prevalence of actionable mutations among 380 targeted sequencing analyses
  11. 256791
    por Permuth, Jennifer B., Dezsi, Kaleena B., Vyas, Shraddha, Ali, Karla N., Basinski, Toni L., Utuama, Ovie A., Denbo, Jason W., Klapman, Jason, Dam, Aamir, Carballido, Estrella, Kim, Dae Won, Pimiento, Jose M., Powers, Benjamin D., Otto, Amy K., Choi, Jung W., Chen, Dung-Tsa, Teer, Jamie K., Beato, Francisca, Ward, Alina, Cortizas, Elena M., Whisner, Suzanne Y., Williams, Iverson E., Riner, Andrea N., Tardif, Kenneth, Velanovich, Vic, Karachristos, Andreas, Douglas, Wade G., Legaspi, Adrian, Allan, Bassan J., Meredith, Kenneth, Molina-Vega, Manual A., Bao, Philip, St. Julien, Jamii, Huguet, Kevin L., Green, Lee, Odedina, Folakemi T., Kumar, Nagi B., Simmons, Vani N., George, Thomas J., Vadaparampil, Susan T., Hodul, Pamela J., Arnoletti, J. Pablo, Awad, Ziad T., Bose, Debashish, Jiang, Kun, Centeno, Barbara A., Gwede, Clement K., Malafa, Mokenge, Judge, Sarah M., Judge, Andrew R., Jeong, Daniel, Bloomston, Mark, Merchant, Nipun B., Fleming, Jason B., Trevino, Jose G.
    Publicado 2021
    “…SIMPLE SUMMARY: Pancreatic cancer is the third leading cause of cancer deaths and is projected to become the second leading cause by 2030. …”
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    The Florida Pancreas Collaborative Next-Generation Biobank: Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer
  12. 256792
    “…No treatment-related deaths were reported. CONCLUSION: Although dose adjustments were relatively common in this small group of Japanese patients aged ≥75 years with EGFR mutation-positive NSCLC, discontinuation occurred much less frequently, and most patients were able to stay on treatment for well over a year. …”
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    A phase II study of first-line afatinib for patients aged ≥75 years with EGFR mutation-positive advanced non-small cell lung cancer: North East Japan Study Group trial NEJ027
  13. 256793
    “…During a cohort follow-up of 4,526,452 person-years, there were 16,188 deaths from any cause (3.85%). The points-based model had good discrimination (c-statistic=0.66). …”
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    Development and Validation of Risk Scores for All-Cause Mortality for a Smartphone-Based “General Health Score” App: Prospective Cohort Study Using the UK Biobank
  14. 256794
    “…Lifetime costs, malaria cases, deaths and disability-adjusted life-years (DALYs) were calculated to determine the incremental costs per DALY averted through IRS. …”
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    Cost and cost-effectiveness of indoor residual spraying with pirimiphos-methyl in a high malaria transmission district of Mozambique with high access to standard insecticide-treated nets
  15. 256795
    “…No treatment related deaths occurred. Grade 3 toxicities during induction therapy were: neutropenia (41%), diarrhoea (41%), during combined treatment: neutropenia (62%) and thrombocytopenia (25%). …”
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    Dose-escalated radiotherapy with PET/CT based treatment planning in combination with induction and concurrent chemotherapy in locally advanced (uT3/T4) squamous cell cancer of the esophagus: mature results of a phase I/II trial
  16. 256796
    “…Drug-related TEAEs leading to permanent discontinuation occurred in 140 (16.6%) patients, and IRs (95% confidence interval) per 100 PY of serious infections, herpes zoster-related disease, and malignancies were 2.7 (2.1, 3.4), 7.3 (6.2, 8.6), and 1.2 (0.9, 1.8), respectively. Two deaths occurred during the study; one each from diffuse large B cell lymphoma and pneumonia, which were, respectively considered probably and possibly related to study drug. …”
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    Safety and Effectiveness of Peficitinib (ASP015K) in Patients with Rheumatoid Arthritis: Final Results (32 Months of Mean Peficitinib Treatment) From a Long-Term, Open-Label Extension Study in Japan, Korea, and Taiwan
  17. 256797
    “…Based on chest CT, the median maximum PII of lungs was 30.0% (range: 0–97.5%), and the median PII after discharge in the patients excluding the two deaths was 12.5% (range: 0–53.0%). PII was significantly negatively correlated with the LYM count and significantly positively correlated with body temperature, LDH, CRP, and ESR. …”
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    The role of chest CT quantitative pulmonary inflammatory index in the evaluation of the course and treatment outcome of COVID-19 pneumonia
  18. 256798
    por Chen, Jie, Rodopoulou, Sophia, de Hoogh, Kees, Strak, Maciej, Andersen, Zorana J., Atkinson, Richard, Bauwelinck, Mariska, Bellander, Tom, Brandt, Jørgen, Cesaroni, Giulia, Concin, Hans, Fecht, Daniela, Forastiere, Francesco, Gulliver, John, Hertel, Ole, Hoffmann, Barbara, Hvidtfeldt, Ulla Arthur, Janssen, Nicole A. H., Jöckel, Karl-Heinz, Jørgensen, Jeanette, Katsouyanni, Klea, Ketzel, Matthias, Klompmaker, Jochem O., Lager, Anton, Leander, Karin, Liu, Shuo, Ljungman, Petter, MacDonald, Conor J., Magnusson, Patrik K.E., Mehta, Amar, Nagel, Gabriele, Oftedal, Bente, Pershagen, Göran, Peters, Annette, Raaschou-Nielsen, Ole, Renzi, Matteo, Rizzuto, Debora, Samoli, Evangelia, van der Schouw, Yvonne T., Schramm, Sara, Schwarze, Per, Sigsgaard, Torben, Sørensen, Mette, Stafoggia, Massimo, Tjønneland, Anne, Vienneau, Danielle, Weinmayr, Gudrun, Wolf, Kathrin, Brunekreef, Bert, Hoek, Gerard
    Publicado 2021
    “…RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. …”
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    Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality—a Pooled Analysis of Eight European Cohorts within the ELAPSE Project
  19. 256799
    “…Therefore, physicians should pay more attention to prevention of viral spread and patients deaths when providing antiviral treatments to patients of older age groups. …”
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    Effectiveness of potential antiviral treatments in COVID-19 transmission control: a modelling study
  20. 256800
    “…BACKGROUND: Although maternal deaths are rare in developed regions, the morbidity associated with severe postpartum hemorrhage (SPPH) remains a major problem. …”
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    Prevalence and risk factors of severe postpartum hemorrhage: a retrospective cohort study
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