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257181por Kaddam, Lamis, Babiker, Rasha, Ali, Sara, Satti, Shahinaz, Ali, Nour, Elamin, Maha, Mukhtar, Mowaia, Elnimeiri, Mustafa, Saeed, Amal“…Mortality rate: The percentage of deaths among COVID 19 patients received Gum Arabic compared to placebo (Four weeks from the start of randomization]). …”
Publicado 2020
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257182por Vaidya, Jayant S, Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik L, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R, Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Le Blanc-Onfroy, Magali, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J, Niewald, Marcus, Blohmer, Jens, McCready, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David J, Tobias, Jeffrey S“…In the first five years, 13 additional local recurrences were reported (24/1140 v 11/1158) but 14 fewer deaths (42/1140 v 56/1158) for TARGIT-IORT compared with EBRT. …”
Publicado 2020
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257183por Jing, Qin-Long, Liu, Ming-Jin, Zhang, Zhou-Bin, Fang, Li-Qun, Yuan, Jun, Zhang, An-Ran, Dean, Natalie E, Luo, Lei, Ma, Meng-Meng, Longini, Ira, Kenah, Eben, Lu, Ying, Ma, Yu, Jalali, Neda, Yang, Zhi-Cong, Yang, Yang“…BACKGROUND: As of June 8, 2020, the global reported number of COVID-19 cases had reached more than 7 million with over 400 000 deaths. The household transmissibility of the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains unclear. …”
Publicado 2020
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257184por Armaroli, Giulia, Klein, Ariane, Ganser, Gerd, Ruehlmann, Michael J., Dressler, Frank, Hospach, Anton, Minden, Kirsten, Trauzeddel, Ralf, Foeldvari, Ivan, Kuemmerle-Deschner, Jasmin, Weller-Heinemann, Frank, Urban, Andreas, Horneff, Gerd“…Three and two malignancies were documented in the etanercept and biologic-naïve groups, as well as three and one deaths, respectively. CONCLUSIONS: No new safety signal was observed, especially no increased risk for malignancies or autoimmune disorders other than inflammatory bowel disease. …”
Publicado 2020
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257185por McLean, Alistair R D, Indrasuta, Chanida, Khant, Zay Soe, Phyo, Aung Kyaw, Maung, Sai Maung, Heaton, James, Aung, Hein, Aung, Ye, Soe, Kyaw, Swe, Myo Maung Maung, von Seidlein, Lorenz, Tun, Ni Ni, Tun, Kyaw Myo, Day, Nicholas P J, Ashley, Elizabeth A, Hlaing, Thaung, Kyaw, Thar Tun, Dondorp, Arjen M, Imwong, Mallika, White, Nicholas J, Smithuis, Frank M“…No treatment-related deaths occurred. INTERPRETATION: In this low-transmission setting, the substantial reduction in P falciparum prevalence resulting from support of community case management was accelerated by MDA. …”
Publicado 2021
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257186por Monje, Fred, Ario, Alex Riolexus, Musewa, Angella, Bainomugisha, Kenneth, Mirembe, Bernadette Basuta, Aliddeki, Dativa Maria, Eurien, Daniel, Nsereko, Godfrey, Nanziri, Carol, Kisaakye, Esther, Ntono, Vivian, Kwesiga, Benon, Kadobera, Daniel, Bulage, Lilian, Bwire, Godfrey, Tusiime, Patrick, Harris, Julie, Zhu, Bao-Ping“…RESULTS: We identified 2122 case-patients and 44 deaths (CFR = 2.1%). Case-patients originating from Demographic Republic of Congo were the most affected (AR = 15/1000). …”
Publicado 2020
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257187“…BACKGROUND: Cervical cancer is the leading cause of cancer deaths among women in developing countries. Since cervical cancer is a preventable disease, screening is an important control and prevention strategy, recommended by the World Health Organization (WHO) for all women aged 30 years and older, and even earlier for some high-risk women. …”
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257188por Wang, Jing-Bo, Wang, Hai-Tao, Wang, Lei-Shi, Li, Lu-Ping, Xv, Jiao, Xv, Chun, Li, Xing-Hai, Wu, Yun-Hai, Liu, Hong-Yan, Li, Bai-Jun, Yu, Hong, Tian, Xia, Zhang, Zhi-Yu, Wang, Yan, Zhao, Rui, Liu, Jin-Yang, Wang, Wei, Gu, Ye“…There were 5 mild cases (5/56, 8.9%), 40 moderate cases (40/56, 71.4%), 10 severe cases (10/56, 17.9%), and 1 critical case (1/56, 1.8%). No deaths were reported. CONCLUSION: SARS-CoV-2 can be transmitted among humans. …”
Publicado 2020
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257189“…METHODS AND FINDINGS: We conducted a population-based cohort analysis of medical records from 389 primary care practices contributing data to the United Kingdom Clinical Practice Research Datalink (CPRD), linked to hospital admissions and deaths in 1998–2017. We estimated time-variant daily and cumulative glucocorticoid prednisolone-equivalent dose-related risks and hazard ratios (HRs) of first all-cause and type-specific cardiovascular diseases (CVDs). …”
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257190por Mattar, Salim, Martinez-Bravo, Caty, Rivero, Ricardo, Contreras, Héctor, Faccini-Martínez, Álvaro A., Guzman-Teran, Camilo, Galeano, Ketty, Alvis-Guzman, Nelson, Contreras, Verónica, Arrieta, German, Gonzalez-Tous, Marco, Miranda, Jorge, Ospina, Martha, Camargo-Assis, Francisco, Mercado-Reyes, Marcela, Garay, Evelyn, Garcia-Perez, Alejandra, Lopez, Yesica, Tique, Vaneza“…In the last 6 months, SARS-CoV-2 has caused millions of reported cases and hundreds of thousands of deaths. As other world regions, South America has not contained the pandemic’s advance since it lacks the hospital and economic capacities. …”
Publicado 2020
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257191por Jahan, Yasmin, Rahman, Md Moshiur, Faruque, Abu S G, Chisti, Mohammod Jobayer, Kazawa, Kana, Matsuyama, Ryota, Moriyama, Michiko“…BACKGROUND: Hypertension (HTN) is a major modifiable risk factor and the leading cause of premature deaths globally. The lack of awareness and knowledge have been identified as risk factors in low- and middle-income countries including Bangladesh. …”
Publicado 2020
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257192por Muir, Lori A, Walpole, Susannah M, Warfel, Patricia A, Kwak, Hanna, Phelan, Anne-Marie, Moore, Gary E, Jain, Akash, Keutzer, Tim, Dane, Aaron, Dane, Aaron, Melnick, David, Talley, Angela K“…Serious adverse events were infrequent (1.3% vs. 1.7%), with no deaths. CONCLUSION: Results from this pivotal Phase 3 study provide the first head-to-head demonstration of non-inferiority of an oral (TBP-PI-HBr) antibacterial agent to an IV (ertapenem) agent in patients with cUTI and AP, with a comparable tolerability profile. …”
Publicado 2020
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257193por Desai, Amit, Helmick, Melanie, Heo, Nakyo, Moy, Selina, Stanhope, Stephen, Goldwater, Ronald, Martin, Nancy“…The geometric LS mean ratio and 90% Confidence Intervals for the C(max), AUC(last), AUC(inf), and AUC(72) are completely contained within the prespecified limits of 80% to 125%. There were no deaths or serious adverse events that led to withdrawal of treatment during the conduct of the study. …”
Publicado 2020
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257194por Chang, Leejah, Anderson, Evan J, Jeanfreau, Robert, He, Ying, Hicks, Bryony, Shrestha, Anju, Pandey, Aseem, Khoury, Rawia, De Bruijn, Iris, Landolfi, Victoria“…No related serious adverse events or deaths occurred. A dose-related increase in HAI GMT ratio was observed across the age range for A/H3N2 but only in children 6 months through < 3 years for A/H1N1 and the 2 B strains (Table 2). …”
Publicado 2020
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257195por Pappas, Peter, Kullberg, Bart Jan, Vazquez, Jose A, Oren, Ilana, Rahav, Galia, Aoun, Mickaël, Bulpa, Pierre, Ben-Ami, Ronen, Ferrer, Ricard, McCarty, Todd P, Thompson III, George R, Barbat, Sara, Wedel, Pamela, Oborska, Iwonka, Schlamm, Haran T, Hodges, Michael“…Survival at day 30 was 85% (17/20); 3 deaths were not related FMGX. FMGX was well-tolerated with no treatment-related serious adverse events or discontinuations. …”
Publicado 2020
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257196por Pritchard, Haley, Hiles, Jon, Teresa, Batteiger, Desai, Armisha, Wrin, Justin E, Hlavaty, Ariel, Agard, Amanda, Hinton, Bradley, Lucky, Christine W, Fleming, Elizabeth, Khan, Humaira, Bomkamp, John P, Derringer, Jon, Schneider, Jack, Ryder, Jonathan, Russ, Jason D, Khan, Haseeba, Kleyman, Svetlana, Enane, Leslie A, Stack, Matthew, Kussin, Michelle L, Myers, Courtney, Nagy, Allysa, Richardson, Noah, Elsheikh, Omar, Rahman, Omar, Kruer, Rachel, Trigonis, Russell, Butt, Saira, Bhumbra, Samina, Kapil, Sasha, Abi-Mansour, Tanya, Howe, Zachary, Abdallah, Wassim, Gupta, Samir, Wools-Kaloustian, Kara“…BACKGROUND: The SARS-CoV-2 pandemic has caused over 400,000 deaths worldwide thus far, and poses therapeutic challenges for millions of patients. …”
Publicado 2020
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257197“…RESULTS: Between 14APR2020 and 09MAY2020, at the peak of deaths in New York, there were 202 IPPs in 29 patients. …”
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257198por Rugo, Hope S., Im, Seock-Ah, Cardoso, Fatima, Cortés, Javier, Curigliano, Giuseppe, Musolino, Antonino, Pegram, Mark D., Wright, Gail S., Saura, Cristina, Escrivá-de-Romaní, Santiago, De Laurentiis, Michelino, Levy, Christelle, Brown-Glaberman, Ursa, Ferrero, Jean-Marc, de Boer, Maaike, Kim, Sung-Bae, Petráková, Katarína, Yardley, Denise A., Freedman, Orit, Jakobsen, Erik H., Kaufman, Bella, Yerushalmi, Rinat, Fasching, Peter A., Nordstrom, Jeffrey L., Bonvini, Ezio, Koenig, Scott, Edlich, Sutton, Hong, Shengyan, Rock, Edwin P., Gradishar, William J.“…After the second planned interim analysis of 270 deaths, median OS was 21.6 months with margetuximab vs 19.8 months with trastuzumab (HR, 0.89; 95% CI, 0.69-1.13; P = .33; September 10, 2019), and investigator-assessed PFS showed 29% relative risk reduction favoring margetuximab (HR, 0.71; 95% CI, 0.58-0.86; P < .001; median, 5.7 vs 4.4 months; September 10, 2019). …”
Publicado 2021
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257199por Reddy, Krishna P, Shebl, Fatma M, Foote, Julia H A, Harling, Guy, Scott, Justine A, Panella, Christopher, Fitzmaurice, Kieran P, Flanagan, Clare, Hyle, Emily P, Neilan, Anne M, Mohareb, Amir M, Bekker, Linda-Gail, Lessells, Richard J, Ciaranello, Andrea L, Wood, Robin, Losina, Elena, Freedberg, Kenneth A, Kazemian, Pooyan, Siedner, Mark J“…FINDINGS: When R(e) was 1·5, health-care testing alone resulted in the highest number of COVID-19 deaths during the 360-day period. Compared with health-care testing alone, a combination of health-care testing, contact tracing, use of isolation centres, mass symptom screening, and use of quarantine centres reduced mortality by 94%, increased health-care costs by 33%, and was cost-effective (ICER $340 per year of life saved). …”
Publicado 2021
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257200por Mittra, Indraneel, Mishra, Gauravi A, Dikshit, Rajesh P, Gupta, Subhadra, Kulkarni, Vasundhara Y, Shaikh, Heena Kauser A, Shastri, Surendra S, Hawaldar, Rohini, Gupta, Sudeep, Pramesh, C S, Badwe, Rajendra A“…A non-significant 15% reduction in breast cancer mortality was observed in the screening arm versus control arm in the overall study population (age 35-64; 20.82 deaths per 100 000 person years (95% confidence interval 18.25 to 23.97) v 24.62 (21.71 to 28.04); rate ratio 0.85 (95% confidence interval 0.71 to 1.01); P=0.07). …”
Publicado 2021
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