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  1. 9201
    por Possas, Cristina
    Publicado 2016
    “…The immunologically naïve status of populations in the Americas, previous infection with dengue virus, and the increased activity of Aedes aegypti might be the contributing factors for such an outbreak in Brazil. …”
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    Online Artículo Texto
    Zika: what we do and do not know based on the experiences of Brazil
  2. 9202
    “…Together with chikungunya virus (CHIKV) and dengue virus (DENV), ZIKV is transmitted by Aedes mosquitoes. …”
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    Online Artículo Texto
    Zika Virus, a New Threat for Europe?
  3. 9203
    “…Strikingly, although ZIKV and dengue virus (DENV) apo-helicases share conserved residues for RNA binding, their different manners of motor domain rotations result in distinct individual modes for RNA recognition. …”
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    Structural basis of Zika virus helicase in recognizing its substrates
  4. 9204
    “…Other globally relevant flaviviruses include dengue virus (DENV) and West Nile virus (WNV). High-resolution structures of ZIKV reveal many similarities to DENV and suggest some differences, including an extended glycan loop (D. …”
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    Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses
  5. 9205
    “…Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family. …”
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    Virtual Screening for Potential Inhibitors of NS3 Protein of Zika Virus
  6. 9206
    “…Using this platform, we found misincorporated dNs occurring at 1 per 10(3) to 10(5) ribonucleotide (nt) in mRNA, rRNAs and tRNA in human cells, Escherichia coli, Saccharomyces cerevisiae and, most abundantly, in the RNA genome of dengue virus. The frequency of dNs varied widely among organisms and sequence contexts, and partly reflected the in vitro discrimination efficiencies of different RNA polymerases against 2′-deoxyribonucleoside 5′-triphosphates (dNTPs). …”
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    The role of sequence context, nucleotide pool balance and stress in 2′-deoxynucleotide misincorporation in viral, bacterial and mammalian RNA
  7. 9207
    “…Here we systematically profiled transcriptomes of human neural progenitor cells exposed to Asian ZIKV(C), African ZIKV(M), and dengue virus (DENV). In contrast to the robust global transcriptome changes induced by DENV, ZIKV has a more selective and larger impact on expression of genes involved in DNA replication and repair. …”
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    Molecular signatures associated with ZIKV exposure in human cortical neural progenitors
  8. 9208
    “…Mosquito host factors play key roles in virus control and it has been suggested that dengue virus replication is regulated by Dnmt2-mediated DNA methylation. …”
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    Comprehensive DNA methylation analysis of the Aedes aegypti genome
  9. 9209
    “…In a case study, we use CHAT to construct a network of genes that are differentially expressed in Dengue fever, a viral infection. CHAT was used to identify and compare contextual and degree-based hubs in this network. …”
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    Contextual Hub Analysis Tool (CHAT): A Cytoscape app for identifying contextually relevant hubs in biological networks
  10. 9210
    “…Its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, West Nile, and the recently emerged Zika fever. …”
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    The Worldwide Spread of the Tiger Mosquito as Revealed by Mitogenome Haplogroup Diversity
  11. 9211
    “…Water quality and waterborne diseases like hepatitis, cholera, typhoid, malaria and dengue fever are increasing due to chaotic urbanization, industrialization, poor hygienic conditions, and inappropriate water management. …”
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    Water-Related Impacts of Climate Change on Agriculture and Subsequently on Public Health: A Review for Generalists with Particular Reference to Pakistan
  12. 9212
    “…In addition, the RT-RPA and RT-PCR assays do not cross-react with dengue and chikungunya viral RNA. This low-cost system lacks complicated, sensitive and high cost components, making it suitable for resource-limited settings. …”
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    Rapid, Affordable and Portable Medium-Throughput Molecular Device for Zika Virus
  13. 9213
    “…More than half of the world population is at risk of vector-borne diseases including dengue fever, chikungunya, zika, yellow fever, leishmaniasis, chagas disease, and malaria, with highest incidences in tropical regions. …”
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    Declining Prevalence of Disease Vectors Under Climate Change
  14. 9214
    “…Dengue is an emerging infectious disease of global significance. …”
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    The Influence of Urbanization Modes on the Spatial Circulation of Flaviviruses within Ouagadougou (Burkina Faso)
  15. 9215
    “…Zika virus (ZIKV) is a member of the Flaviviridae family, along with other agents of clinical significance such as dengue (DENV) and hepatitis C (HCV) viruses. Since ZIKV causes neurological disorders during fetal development and in adulthood, antiviral drugs are necessary. …”
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    The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
  16. 9216
    “…BACKGROUND: Aedes aegypti is the main vector of important arboviruses such as dengue, Zika and chikungunya. During infections mosquitoes can activate the immune pathways Toll, IMD and JAK/STAT to limit pathogen replication. …”
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    Microbiota activates IMD pathway and limits Sindbis infection in Aedes aegypti
  17. 9217
    “…We applied the Cre/lox recombinase-mediated cassette exchange (RMCE) system to Aedes aegypti, the vector of dengue, chikungunya, and Zika viruses. In this context we created four target site lines for RMCE and evaluated their fitness costs. …”
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    Cre/lox-Recombinase-Mediated Cassette Exchange for Reversible Site-Specific Genomic Targeting of the Disease Vector, Aedes aegypti
  18. 9218
    “…Analyses of human hepatic cells and neural progenitor cells infected with ZIKV revealed endoplasmic reticulum (ER) membrane invaginations containing pore-like openings toward the cytosol, reminiscent to RFs in Dengue virus-infected cells. Both the MR766 African strain and the H/PF/2013 Asian strain, the latter linked to neurological diseases, induce RFs of similar architecture. …”
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    Ultrastructural Characterization of Zika Virus Replication Factories
  19. 9219
    “…The mosquito Aedes aegypti (Ae. aegypti) is the most notorious vector of illness-causing viruses such as Dengue, Chikugunya, and Zika. Although numerous genetic expression studies utilizing quantitative real-time PCR (qPCR) have been conducted with regards to Ae. aegypti, a panel of genes to be used suitably as references for the purpose of expression-level normalization within this epidemiologically important insect is presently lacking. …”
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    Evaluation of reference genes at different developmental stages for quantitative real-time PCR in Aedes aegypti
  20. 9220
    “…There is a need for new interventions against the ongoing burden of vector-borne diseases such as malaria and dengue. One suggestion has been to develop genes encoding effector molecules that block parasite development within the vector, and then use the nuclease-based homing reaction as a form of gene drive to spread those genes through target populations. …”
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    Requirements for Driving Antipathogen Effector Genes into Populations of Disease Vectors by Homing
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