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194861por Gomes, Ana, Bessa, Lucinda J., Fernandes, Iva, Ferraz, Ricardo, Mateus, Nuno, Gameiro, Paula, Teixeira, Cátia, Gomes, Paula“…Many such bacteria are frequently isolated from severely infected skin lesions such as diabetic foot ulcers (DFU). In this connection, we are pursuing new peptide constructs encompassing antimicrobial and collagenesis-inducing motifs, to tackle skin and soft tissue infections by exerting a dual effect: antimicrobial protection and faster healing of the wound. …”
Publicado 2019
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194862por Boddapati, Venkat, Held, Michael B., Lee, Nathan J., Geller, Jeffrey A., Cooper, H. John, Shah, Roshan P.“…Patients with nonexpedited surgery were more likely to be older, female, and diabetic, received general anesthesia, and had a higher American Society of Anesthesiologists class, dependent functional status, and longer operative time. …”
Publicado 2019
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194863por Adsul, Nitin, Kalra, K. L., Jain, Nikhil, Haritwal, Mukesh, Chahal, R. S., Acharya, Shankar, Jain, Sunila“…CASE DESCRIPTION: A 45-year-old, type II diabetic female presented with a 5-month history of severe back pain. …”
Publicado 2019
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194864por Cristóbal, Lara, de los Reyes, Nerea, Ortega, Miguel A., Álvarez-Mon, Melchor, García-Honduvilla, Natalio, Buján, Julia, Maldonado, Andrés A.“…We hypothesize whether it is possible to improve pressure ulcer (PU) healing by locally applying the recombinant human growth hormone (rhGH) in a human skin mouse model. Non-obese diabetic/severe combined immunodeficient mice (n = 10) were engrafted with a full-thickness human skin graft. …”
Publicado 2019
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194865“…We have previously shown beneficial effects of fermented green tea with Aquilariae Lignum (fGT) via an oral route in diabetic and obese models. Thus, the toxicological safety of fGT was assessed at limited oral doses for a rodent. …”
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194866por Chen, Yuyu, Zhang, Li, Liu, Shuangxin, Yao, Binfeng, Zhang, Hong, Liang, Shun, Ma, Jianchao, Liang, Xinling, Shi, Wei“…Hyperglycemia promotes podocyte apoptosis and contributes to the pathogenesis of diabetic nephropathy (DN). However, the mechanisms of hyperglycemia-induced podocyte apoptosis remain unknown. …”
Publicado 2019
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194867por Edén, Desirée, Panagiotou, Grigorios, Mokhtari, Dariush, Eriksson, Jan W., Åberg, Mikael, Siegbahn, Agneta“…Background: Tissue factor (TF) combined with its ligand FVII initiates blood coagulation and intracellular signaling. Obese and type 2 diabetic subjects have increased TF expression in their adipose tissue and an increased risk for thrombotic complications. …”
Publicado 2019
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194868por Karanth, Santhosh, Chaurasia, Bhagirath, Bowman, Faith M., Tippetts, Trevor S., Holland, William L., Summers, Scott A., Schlegel, Amnon“…The FOXN3 gene locus is associated with fasting blood glucose levels in non‐diabetic human population genetic studies. The blood glucose‐modifying variation within this gene regulates the abundance of both FOXN3 protein and transcript in primary human hepatocytes, with the hyperglycemia risk allele causing increases in both FOXN3 protein and transcript. …”
Publicado 2019
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194869“…BACKGROUND: Mucormycosis is an invasive fungal infection (IFI) most commonly seen in immunocompromised patients. Diabetic ketoacidosis, haematopoietic transplantation, iron overload states, and deferoxamine therapy are considered to be some of the classical risk factors. …”
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194870por Thounaojam, Menaka C., Jadeja, Ravirajsinh N., Warren, Marie, Powell, Folami L., Raju, Raghavan, Gutsaeva, Diana, Khurana, Sandeep, Martin, Pamela M., Bartoli, Manuela“…Stress-associated premature senescence (SAPS) is involved in retinal microvascular injury and diabetic retinopathy. We have investigated the role and mode of action of miR-34a in retinal endothelial cells senescence in response to glucidic stress. …”
Publicado 2019
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194871por Lachowicz, Sabina, Wiśniewski, Rafał, Ochmian, Ireneusz, Drzymała, Katarzyna, Pluta, Stanisław“…The aim of the present work was to evaluate for content of phytochemicals (monophosphate nucleotides, free amino acids, polyphenols), and for anti-microbiological, anti-diabetic (ability to inhibit pancreatic lipase, α-glucosidase, and α-amylase), and antioxidant activities in seven selected fruit and fruit fractions of Amelanchier alnifolia. …”
Publicado 2019
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194872por De Angelis, Barbara, D’Autilio, Margarida Fernandes Lopes Morais, Orlandi, Fabrizio, Pepe, Giampiero, Garcovich, Simone, Scioli, Maria Giovanna, Orlandi, Augusto, Cervelli, Valerio, Gentile, Pietro“…Our observational study reports on an in vitro and in vivo evaluation of a bio-functionalized scaffold composed of platelet-rich plasma (PRP) and hyaluronic acid (HA) used in 182 patients affected by chronic ulcers (diabetic and vascular), comparing the results with a control group of 182 patients treated with traditional dressings (HA alone). …”
Publicado 2019
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194873por Chun, Lindsay Y., Silas, Megan R., Dimitroyannis, Rose C., Ho, Kimberly, Skondra, Dimitra“…PURPOSE: To investigate if there are differences in macular capillaries between black and white subjects using optical coherence tomography angiography (OCTA) and identify potential factors underlying the epidemiologically-based higher vulnerability of black populations to diabetic retinopathy (DR). METHODS: This prospective, observational cross-sectional study included 93 eyes of 47 healthy subjects with no medical history and ocular history who self-identified as black or white and were matched for age, sex, refractive error, and image quality. …”
Publicado 2019
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194874por Lasolle, Hélène, Ferriere, Amandine, Vasiljevic, Alexandre, Eimer, Sandrine, Nunes, Marie-Laure, Tabarin, Antoine“…Hyperglycemia was frequent and greater in diabetic patients. 7/15 patients stopped Pasireotide-LAR due to lack of control of IGF-1 or intolerance. 8/15 patients received Pasireotide-LAR for a median of 29 months with IGF-1 levels ≤1.3 ULN and acceptable glucose tolerance (median HbA1c 6.1%). …”
Publicado 2019
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194875por Yoon, Sorah, Huang, Kai-Wen, Andrikakou, Pinelopi, Vasconcelos, Daniel, Swiderski, Piotr, Reebye, Vikash, Sodergren, Mikael, Habib, Nagy, Rossi, John J.“…For in vivo assays, we established an advanced PDAC mouse model by engrafting luciferase reporter-PANC-1 cells directly into the livers of non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice. …”
Publicado 2019
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194876por López, Edith, Lee-Rivera, Irene, Alvarez-Arce, Alejandro, López-Colomé, Ana María“…In this condition, elevated extracellular glutamate causes neuronal loss in many retinal disorders, including glaucoma, ischemia, diabetic retinopathy, and inherited photoreceptor degeneration. …”
Publicado 2019
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194877“…(ii) Digitally model disease trajectory in a mouse model of diabetic nephropathy (DN). METHODS/STUDY POPULATION: We have developed a computational pipeline for glomerular structural compartmentalization based on Gabor filtering and multiresolution community detection (MCD). …”
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194878por Marquis, Bryce J., Carvahlo, Eugenia, Hurren, Nicholas, Wolfe, Robert R., Borsheim, Elisabet“…DISCUSSION/SIGNIFICANCE OF IMPACT: EAA supplementation has potential to improve lipid metabolism and plasma TG levels in non-diabetic older adults. Mitochondrial metabolomics suggest that insufficient TCA pool size may limit tissue fatty acid oxidation and may provide an additional route for nutritional therapy.…”
Publicado 2018
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194879por Mahmood, Tuba, Raj, Kuldeep, Ehtesham, Moiz, Bhimani, Joty, Jabeen, Shah, Tahir, Amber“…Younger patients with non-ischemic CHF, and history of previous diagnosis, treatment, and hospitalization due to CHF were more likely to be affected. Diabetic nephropathy, chronic kidney disease, salt-restricted diet, drugs including furosemide, spironolactone, and angiotensin-converting enzyme inhibitors, low serum potassium, and reduced GFR were also related to hyponatremia. …”
Publicado 2019
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194880por Brown, Nicholas M., Blane, Beth, Raven, Kathy E., Kumar, Narender, Leek, Danielle, Bragin, Eugene, Rhodes, Paul A., Enoch, David A., Thaxter, Rachel, Parkhill, Julian, Peacock, Sharon J.“…Both analysis methods identified two MRSA clusters based on relatedness, one of which contained 3 cases that were involved in an outbreak linked to a clinic and ward associated with diabetic patient care. We conclude that, in this pilot study, the NGD system provided rapid and accurate data that could support infection control practices.…”
Publicado 2019
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