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196181“…However, in most cases, repeated islet transplantation is needed to achieve normoglycemia in diabetic recipients. This study aimed to investigate whether there are differences in islet survival and engraftment between a first and a second transplantation, performed 1 week apart, to the liver. …”
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196182por Antonellis, Patrick J., Droz, Brian A., Cosgrove, Richard, O'Farrell, Libbey S., Coskun, Tamer, Perfield, James W., Bauer, Steven, Wade, Mark, Chouinard, Tara E., Brozinick, Joseph T., Adams, Andrew C., Samms, Ricardo J.“…Administration of FGF19 to obese/diabetic mice lowers body weight, improves insulin sensitivity, and enhances glycemic control. …”
Publicado 2019
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196183“…The pooled mean difference of visual improvement between sham and ranibizumab was 12.7 Early Treatment for Diabetic Retinopathy Study (ETDRS) letters (95%CI: 11.00 to 13.2), and the pooled mean difference in CMT reduction was 221 [Formula: see text] m (95%CI: 153 to 284); both changes were significantly in favor of ranibizumab. …”
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196184“…BACKGROUND: Some Gynura species have been reported to be natural anti-diabetic plants. Improvement of their traits towards application relies on hybridization. …”
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196185“…RESULTS: We reviewed the results from 659 patients, mean age 57 ± 16 years, 56.3% male, 38.9% diabetic, 24.0% treated by CAPD, 22.5% by APD and 53.5% APD with a day-time exchange, with icodextrin prescribed to 72.8% and 22.7 g/L glucose to 31.7%. …”
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196186“…BACKGROUND: It is well established that inflammation and apoptosis of renal tubular epithelial cells caused by hyperglycemia contribute to the development of diabetic nephropathy (DN). Although microRNAs (miRNAs) are known to have roles in inflammation-related disorders, the exact role of miR-34b in DN has not been defined, and the regulatory mechanism has been unclear. …”
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196187“…RESULTS: Mean age of patients was 52.57±12.47 and the most common ethnicity were Punjabi speaking population (66%). Diabetic neuropathy (51%) was the most common etiology followed by radicular pain (25%). …”
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196188por Zhang, Wei, Huang, Rui, Wang, Yi, Rao, Huiying, Wei, Lai, Su, Grace L., Lok, Anna S.“…A total of 160 NAFLD patients were included (46% men, median age 47 years): 50% had normal body mass index (BMI), 24% were diabetic, and 56% had metabolic syndrome (MS). Fifty‐three (33%) had moderate/severe steatosis, of whom 19 (35.8%) had normal BMI, and the rest had mild steatosis. …”
Publicado 2019
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196189por Mathews Samuel, Samson, Satheesh, Noothan Jyothi, Ghosh, Suparna, Büsselberg, Dietrich, Majeed, Yasser, Ding, Hong, Triggle, Chris R.“…Metformin, the most widely used anti-diabetic drug, also exhibits anti-cancer properties; however, the true potential of metformin as an anticancer drug remains largely unknown. …”
Publicado 2019
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196190por Nagasu, Hajime, Sogawa, Yuji, Kidokoro, Kengo, Itano, Seiji, Yamamoto, Toshiya, Satoh, Minoru, Sasaki, Tamaki, Suzuki, Takafumi, Yamamoto, Masayuki, Wigley, W. Christian, Proksch, Joel W., Meyer, Colin J., Kashihara, Naoki“…Our data show that dh404 significantly reduced proteinuria-induced tubular cell mitochondrial damage, suggesting that improved redox balance and mitochondrial function and suppression of inflammation underlie the cytoprotective mechanism of Nrf2 activators, including bardoxolone methyl, in diabetic kidney disease.—Nagasu, H., Sogawa, Y., Kidokoro, K., Itano, S., Yamamoto, T., Satoh, M., Sasaki, T., Suzuki, T., Yamamoto, M., Wigley, W. …”
Publicado 2019
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196191por Leonard, Alexis, Yapundich, Morgan, Nassehi, Tina, Gamer, Jackson, Drysdale, Claire M., Haro-Mora, Juan J., Demirci, Selami, Hsieh, Matthew M., Uchida, Naoya, Tisdale, John F.“…We assessed human CD45(+) chimerism after transplanting varying doses of human CD34(+) HSCs (2 × 10(5) to 2 × 10(6) cells/mouse) with or without busulfan (BU) pretransplant conditioning in c-kit mutant mice that do not require conditioning (non-obese diabetic [NOD]/B6/severe combined immunodeficiency [SCID]/ interleukin-2 receptor gamma chain null (IL-2rγ(−/−)) Kit(W41/W41) [NBSGW]). …”
Publicado 2019
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196192Mechanism of AMPK-mediated apoptosis of rat gastric smooth muscle cells under high glucose condition“…To observe changes in AMP-activated protein kinase (AMPK) activity and phosphorylation changes in AMPK signaling pathway in gastric smooth muscle cells of rats with diabetic gastroparesis (DGP), investigate the effect of AMPK on apoptosis and explore the underlying mechanism. …”
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196193por Chen, Hung-Jen, Li Yim, Andrew Y. F., Griffith, Guillermo R., de Jonge, Wouter J., Mannens, Marcel M. A. M., Ferrero, Enrico, Henneman, Peter, de Winther, Menno P. J.“…Adipose tissue-derived macrophages were classified as unstimulated macrophages, but acquired LPS-activation features in diabetic-obese patients. Rheumatoid arthritis synovial macrophages exhibit characteristics of IL10- or IFNγ-stimulation. …”
Publicado 2019
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196194por Yin, Guo Nan, Ock, Jiyeon, Choi, Min-Ji, Song, Kang-Moon, Ghatak, Kalyan, Minh, Nguyen Nhat, Kwon, Mi-Hye, Seong, Do-Hwan, Jin, Hai-Rong, Ryu, Ji-Kan, Suh, Jun-Kyu“…Our study will aid us to understand the pathophysiology of diabetic erectile dysfunction, and also be a valuable tool for determining the efficacy of candidate therapeutic targets.…”
Publicado 2020
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196195“…Among them, alpha-lipoic acid (ALA), as a treatment of diabetic neuropathy, has been applied to improve the quality of sperm in clinical practice, with satisfactory effect. …”
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196196“…PF-04523655, a 19-nucleotide methylated double-stranded siRNA targeting the RTP80 gene, showed a dose-related improvement in best-corrected visual acuity (BCVA) in patients affected by diabetic macular edema. The observed results support a clinical network-based research program aimed to clarify the role of epigenetic regulators in the development of ocular diseases and personalized therapy.…”
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196197por Scondotto, Giulia, Sultana, Janet, Ientile, Valentina, Ingrasciotta, Ylenia, Fontana, Andrea, Copetti, Massimiliano, Mirabelli, Eliana, Trombetta, Costantino J., Rapisarda, Carlo, Reibaldi, Michele, Avitabile, Teresio, Longo, Antonio, Toro, Patricia Ibanez, Vadalà, Maria, Cillino, Salvatore, Virgili, Gianni, Gini, Rosa, Leoni, Olivia, Pollina Addario, Sebastiano Walter, Cananzi, Pasquale, La Cavera, Claudia, Puzo, Maria Rosalia, De Sarro, Giovambattista, De Francesco, Adele, Trifirò, Gianluca“…Bilateral treatment and diabetic macular edema (DME) coding algorithms were validated, linking claims with a sample of prospectively collected ophthalmological data. …”
Publicado 2020
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196198por Baatiah, Nada Yasser, Alhazmi, Raghad Bader, Albathi, Fatmah Ali, Albogami, Esraa Ghazi, Mohammedkhalil, Abdullah Khalid, Alsaywid, Basim Saleh“…The median age of stone disease was 33 years (25%–75%: 26–42 years). Diabetic individuals were 3.2 times more likely to have urolithiasis when compared to nondiabetic individuals (OR = 3.2, 95% CI, 2.1–4.9). …”
Publicado 2020
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196199por Kraus, Frank Bernhard, Kocijancic, Marija, Kluttig, Alexander, Ludwig-Kraus, Beatrice“…INTRODUCTION: The measurement of β-hydroxybutyrate (βOHB) concentrations is a corner stone of the diagnosis of diabetic ketoacidosis and other ketonic states. The aim of this study was to perform a validation of a peripheral blood βOHB assay (Randox) on a Roche cobas c502 analyser and to establish a βOHB reference range for the validated assay. …”
Publicado 2020
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196200por Nagano, Hideki, Goi, Takanori, Taguchi, Seiichi, Tsubaki, Takayoshi, Tsuchiyama, Toshikuni, Uematsu, Hidemasa, Noriki, Sakon“…PATIENT CONCERNS: A 63-year-old Japanese man received hemodialysis for chronic renal failure due to diabetic nephropathy, and a small, gradually enlarging tissue mass was found near the lesser curvature of the stomach on plain CT performed annually, without any associated complaints. …”
Publicado 2020
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