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196361por Bhutta, Maimoona S., Sausen, Daniel G., Reed, Kirstin M., Gallo, Elisa S., Hair, Pamela S., Lassiter, Brittany P., Krishna, Neel K., Cunnion, Kenji M., Borenstein, Ronen“…It has been previously shown to aid in the healing of chronic diabetic wounds by inhibiting the excessive activation of complement component C1 and infiltration of leukocytes. …”
Publicado 2021
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196362por Gao, Junwei, Liu, Peng, Shen, Zhengri, Xu, Ke, Wu, Chenguang, Tian, Feng, Chen, Ming, Wang, Lifan, Li, Ping“…Lipid deposition is an etiology of renal damage caused by lipid metabolism disorder in diabetic nephropathy (DN). Thus, reducing lipid deposition is a feasible strategy for the treatment of DN. …”
Publicado 2021
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196363por Tsakiridis, Evangelia E., Broadfield, Lindsay, Marcinko, Katarina, Biziotis, Olga-Demetra, Ali, Amr, Mekhaeil, Bassem, Ahmadi, Elham, Singh, Kanwaldeep, Mesci, Aruz, Zacharidis, Panayiotis G., Anagnostopoulos, Alexander E., Berg, Tobias, Muti, Paola, Steinberg, Gregory R., Tsakiridis, Theodoros“…BACKGROUND: There is need for well-tolerated therapies for prostate cancer (PrCa) secondary prevention and to improve response to radiotherapy (RT). The anti-diabetic agent metformin (MET) and the aspirin metabolite salicylate (SAL) are shown to activate AMP-activated protein kinase (AMPK), suppress de novo lipogenesis (DNL), the mammalian target of rapamycin (mTOR) pathway and reduce PrCa proliferation in-vitro. …”
Publicado 2021
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196364“…CONTEXT: Oxidative injury in a high-glucose (HG) environment may be a mechanism of diabetic retinopathy (DR) and edaravone can protect retinal ganglion cells by scavenging ROS. …”
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196365“…Delayed healing of diabetic foot ulcers (DFUs) is one of the major consequences of angiopathy caused by hyperglycemia stemming from insulin resistance. …”
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196366por Sripathi, Srinivasa R., Hu, Ming-Wen, Turaga, Ravi Chakra, Mertz, Joseph, Liu, Melissa M., Wan, Jun, Maruotti, Julien, Wahlin, Karl J., Berlinicke, Cynthia A., Qian, Jiang, Zack, Donald J.“…These processes have been implicated in several retinal diseases, including proliferative vitreoretinopathy, diabetic retinopathy, and age-related macular degeneration. …”
Publicado 2021
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196367por Chakraborty, Raja, Chatterjee, Payel, Dave, Jui M., Ostriker, Allison C., Greif, Daniel M., Rzucidlo, Eva M., Martin, Kathleen A.“…We review the mechanisms by which the current drug-eluting stent agents prevent restenosis and note remaining challenges in peripheral and diabetic revascularization for which new approaches would be beneficial. …”
Publicado 2021
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196368“…Introduction Diabetic foot infection is a condition that affects the patient's life, may cause limb loss, and has a high mortality. …”
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196369“…The mean change in BCVA and central macular thickness (CMT) from baseline to 48 weeks was +20.6 ± 5.2 Early Treatment of Diabetic Retinopathy Score letters and −109.2 ± 82.8 µm, respectively. …”
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196370por He, Jianbo, Chen, Kai, Deng, Tiancheng, Xie, Jiewei, Zhong, Kunjing, Yuan, Jinbo, Wang, Ziyi, Xiao, Zhifeng, Gu, Ronghe, Chen, Delong, Li, Xiaojuan, Lin, Dingkun, Xu, Jiake“…Rhaponticin (RH) is a small molecule that has been reported to possess anti-inflammatory, anti-allergic, anti-fibrotic, and anti-diabetic activities. However, the influence of RH on osteoclasts differentiation and function is still unclear. …”
Publicado 2021
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196371por Freynhagen, Rainer, Argoff, Charles, Eerdekens, Mariëlle, Engelen, Sylvia, Perrot, Serge“…SUBJECTS: STRIDE: nondiabetic neuropathic pain; PACE: painful diabetic peripheral neuropathy. METHODS: Patients were divided according to number of applications needed before attainment of a ≥30% reduction in average pain intensity (question 5 of the Brief Pain Inventory [BPI-Q5]). …”
Publicado 2021
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196372por Wang, Xichang, Chen, Kan, Zhang, Chenyu, Wang, Haoyu, Li, Jiashu, Wang, Chuyuan, Teng, Weiping, Shan, Zhongyan, Lai, Yaxin“…All selected studies excluded patients with thyroid dysfunction, and diabetic patients were also excluded when fasting glucose and fasting insulin levels were meta-analyzed. …”
Publicado 2021
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196373“…Currently, neovascular retinal diseases such as retinopathy of prematurity, proliferative diabetic retinopathy, and neovascular age-related macular degeneration, which together constitute the majority of blindness in developed countries, are managed with frequent and costly injections of anti-vascular endothelial growth factor (anti-VEGF) agents that are short-lived and burdensome for patients. …”
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196374por Leeth, Caroline, Adkins, Janie, Hay, Alayna, Bogers, Sophie, Potter, Ashley, Witonsky, Sharon, Zhu, Jing“…Immunocompromised non obese diabetic (NOD). sudden combined immunodeficiency (scid).gamma-/- (NSG) mice were engrafted with either equine peripheral blood lymphocytes (PBLs) or equine bone marrow to determine an optimal protocol for equine lymphocyte engraftment. …”
Publicado 2021
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196375“…Strikingly, efficacy of transfer between adipocytes and erythrocytes was determined by the metabolic state (genotype and feeding state) of the rats, which were used as source for the PM and sera, with upregulation in obese and diabetic rats and counterbalance by serum proteins. …”
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196376por Kim, Hyoung-Geun, Nam, Youn Hee, Jung, Young Sung, Oh, Seon Min, Nguyen, Trong Nguyen, Lee, Min-Ho, Kim, Dae-Ok, Kang, Tong Ho, Lee, Dae Young, Baek, Nam-In“…Furthermore, all compounds recovered the pancreatic islets damaged by alloxan treatment in zebrafish; (4) Conclusions: The outcome proposes 1–4 to serve as components of CLFs in standardizing anti-oxidant, pro-inflammatory inhibition, and potential anti-diabetic agents.…”
Publicado 2021
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196377“…Metformin is an anti-diabetic drug and has anticancer effects on various cancers. …”
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196378por Bian, Nannan, Sun, Xiaomeng, Zhou, Biao, Zhang, Lin, Wang, Qiu, An, Yu, Li, Xiaohui, Li, Yinhui, Liu, Jia, Meng, Hua, Wang, Guang“…METHODS: A total of 287 non-diabetic participants with regular thyroid function were recruited and divided into the lean, overweight and obese groups. …”
Publicado 2021
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196379por Yamazaki, Yuko, Shoji, Tetsuo, Miyashima, Masako, Nagata, Yuki, Kakutani, Yoshinori, Ochi, Akinobu, Morioka, Tomoaki, Nakatani, Shinya, Mori, Katsuhito, Tsujimoto, Yoshihiro, Emoto, Masanori“…This inverse association of FT3 and new CVD events remained significant after adjustment for age, sex, duration of hemodialysis, diabetic kidney disease, hypertension, dyslipidemia, and smoking; however, it was no longer significant after further adjustment for prior CVD or N-terminal fragment of probrain natriuretic peptide (NT-proBNP). …”
Publicado 2021
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196380por Fan, Yuying, Ren, Xiaoli, Wang, Yingxue, Xu, Enshuang, Wang, Shuang, Ge, Ruidong, Liu, Yun“…As an anti-diabetic drug, metformin has been demonstrated to exhibit antitumor effects. …”
Publicado 2021
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