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196741por Yang, Hsin-Chou, Liang, Yu-Jen, Wu, Yi-Lin, Chung, Chia-Min, Chiang, Kuang-Mao, Ho, Hung-Yun, Ting, Chih-Tai, Lin, Tsung-Hsien, Sheu, Sheng-Hsiung, Tsai, Wei-Chuan, Chen, Jyh-Hong, Leu, Hsin-Bang, Yin, Wei-Hsian, Chiu, Ting-Yu, Chen, Chin-Iuan, Fann, Cathy S. J., Wu, Jer-Yuarn, Lin, Teng-Nan, Lin, Shing-Jong, Chen, Yuan-Tsong, Chen, Jaw-Wen, Pan, Wen-Harn“…The latter has been implicated in the abnormal vascular responsiveness to endothelin-1 and angiotensin II in diabetic-hypertensive rats. Intrinsic synergy involving IMPG1 on chromosome 6q14.2-q15 was also verified. …”
Publicado 2009
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196742por Knotts, Trina A., Lee, Hyun Woo, Kim, Jae Bum, Oort, Pieter J., McPherson, Ruth, Dent, Robert, Tachibana, Keisuke, Doi, Takefumi, Yu, Songtao, Reddy, Janardan K., Uno, Kenji, Katagiri, Hideki, Pasarica, Magdalena, Smith, Steven R., Sears, Dorothy D., Grino, Michel, Adams, Sean H.“…No change in Tusc5 mRNA or protein levels was evident in type 2 diabetic patients treated with pioglitazone. Tusc5 expression was not induced appreciably in liver preparations overexpressing PPARs, suggesting that tissue-specific factors regulate PPARγ responsiveness of the TUSC5 gene. …”
Publicado 2009
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196743por Nakanishi, T, Chumsri, S, Khakpour, N, Brodie, A H, Leyland-Jones, B, Hamburger, A W, Ross, D D, Burger, A M“…METHODS: The SPs from luminal-type BC were analysed for BC T-IC characteristics, including human epidermal growth factor receptor 2 (HER2), ERα, IGFBP7 expression and their ability to initiate tumours in non-obese diabetic severe combined immunodeficiency (NOD/SCID) mice. …”
Publicado 2010
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196744por Kwon, Ho-Keun, Hwang, Ji-Sun, So, Jae-Seon, Lee, Choong-Gu, Sahoo, Anupama, Ryu, Jae-Ha, Jeon, Won Kyung, Ko, Byoung Seob, Im, Chang-Rok, Lee, Sung Haeng, Park, Zee Yong, Im, Sin-Hyeog“…They have various biological functions including anti-oxidant, anti-microbial, anti-inflammation, anti-diabetic and anti-tumor activity. Previously, we have reported that anti-cancer effect of cinnamon extracts is associated with modulation of angiogenesis and effector function of CD8(+ )T cells. …”
Publicado 2010
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196745por de Figueiredo-Pontes, Lorena L., Assis, Patricia A., Santana-Lemos, Bárbara A. A., Jácomo, Rafael H., Lima, Ana Sílvia G., Garcia, Aglair B., Thomé, Carolina H., Araújo, Amélia G., Panepucci, Rodrigo A., Zago, Marco A., Nagler, Arnon, Falcão, Roberto P., Rego, Eduardo M.“…Halofuginone (HF), a low-molecular-weight alkaloid that modulates TGFβ signaling, was used to treat APL cell lines and non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice subjected to transplantation with leukemic cells from human chorionic gonadotrophin-PML-RARα transgenic mice (TG). …”
Publicado 2011
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196746por Kim, Bo Hyun, Ko, Young-Guk, Her, Ae-Young, Kim, Jung-Sun, Hwang, Ki-Chul, Shin, Dong-Ho, Kim, Byeong-Keuk, Choi, Donghoon, Ha, Jong-Won, Hong, Myeong-Ki, Jang, Yangsoo“…RESULTS: There were fewer diabetic patients and higher incidence of previous angina and multi-vessel disease in group II. …”
Publicado 2012
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196747por Bates, Matthew G.D., Hollingsworth, Kieren G., Newman, Jane H., Jakovljevic, Djordje G., Blamire, Andrew M., MacGowan, Guy A., Keavney, Bernard D., Chinnery, Patrick F., Turnbull, Douglass M., Taylor, Robert W., Trenell, Michael I., Gorman, Grainne S.“…Among patients there was no correlation of LVMI or the M/V ratio with diabetic or hypertensive status, but the mutation load and NMDAS correlated with the LVMI (r = 0.71 and r = 0.79, respectively, both P < 0.001). …”
Publicado 2013
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196748por Muise, Eric S., Souza, Sandra, Chi, An, Tan, Yejun, Zhao, Xuemei, Liu, Franklin, Dallas-yang, Qing, Wu, Margaret, Sarr, Tim, Zhu, Lan, Guo, Hongbo, Li, Zhihua, Li, Wenyu, Hu, Weiwen, Jiang, Guoqiang, Paweletz, Cloud P., Hendrickson, Ronald C., Thompson, John R., Mu, James, Berger, Joel P., Mehmet, Huseyin“…FGF21 is a novel secreted protein with robust anti-diabetic, anti-obesity, and anti-atherogenic activities in preclinical species. …”
Publicado 2013
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196749por Neilan, Tomas G., Farhad, Hoshang, Dodson, John A., Shah, Ravi V., Abbasi, Siddique A., Bakker, Jessie P., Michaud, Gregory F., van der Geest, Rob, Blankstein, Ron, Steigner, Michael, John, Roy M., Jerosch‐Herold, Michael, Malhotra, Atul, Kwong, Raymond Y.“…Patients with SA (n=142, 20%) were more likely to be male, diabetic, and hypertensive and have an increased pulmonary artery pressure, right ventricular volume, atrial dimensions, and left ventricular mass. …”
Publicado 2013
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196750“…Positive health outcomes were shown in 12 studies, where the clinical outcomes for diabetic patients (HbA1c level) and for asthmatic patients (forced expiratory volume [FEV]) improved. …”
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196751por Sugimoto, Satoru, Nakajima, Hisakazu, Kodo, Kazuki, Mori, Jun, Matsuo, Kensuke, Kosaka, Kitaro, Aoi, Wataru, Yoshimoto, Kanji, Ikegaya, Hiroshi, Hosoi, Hajime“…BACKGROUND: Miglitol is an oral anti-diabetic drug that acts by inhibiting carbohydrate absorption in the small intestine. …”
Publicado 2014
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196752por Queiroz, Eveline A. I. F., Puukila, Stephanie, Eichler, Rosangela, Sampaio, Sandra C., Forsyth, Heidi L., Lees, Simon J., Barbosa, Aneli M., Dekker, Robert F. H., Fortes, Zuleica B., Khaper, Neelam“…Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation by improving insulin sensitivity. …”
Publicado 2014
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196753por Cannarozzi, Gina, Plaza-Wüthrich, Sonia, Esfeld, Korinna, Larti, Stéphanie, Wilson, Yi Song, Girma, Dejene, de Castro, Edouard, Chanyalew, Solomon, Blösch, Regula, Farinelli, Laurent, Lyons, Eric, Schneider, Michel, Falquet, Laurent, Kuhlemeier, Cris, Assefa, Kebebew, Tadele, Zerihun“…BACKGROUND: Tef (Eragrostis tef), an indigenous cereal critical to food security in the Horn of Africa, is rich in minerals and protein, resistant to many biotic and abiotic stresses and safe for diabetics as well as sufferers of immune reactions to wheat gluten. …”
Publicado 2014
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196754por Castro-Quezada, Itandehui, Sánchez-Villegas, Almudena, Estruch, Ramón, Salas-Salvadó, Jordi, Corella, Dolores, Schröder, Helmut, Álvarez-Pérez, Jacqueline, Ruiz-López, María Dolores, Artacho, Reyes, Ros, Emilio, Bulló, Mónica, Covas, María-Isabel, Ruiz-Gutiérrez, Valentina, Ruiz-Canela, Miguel, Buil-Cosiales, Pilar, Gómez-Gracia, Enrique, Lapetra, José, Pintó, Xavier, Arós, Fernando, Fiol, Miquel, Lamuela-Raventós, Rosa María, Martínez-González, Miguel Ángel, Serra-Majem, Lluís“…RESULTS: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). …”
Publicado 2014
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196755por Kanaji, Nobuhiro, Tadokoro, Akira, Susaki, Kentaro, Yokokura, Saki, Ohmichi, Kiyomi, Haba, Reiji, Watanabe, Naoki, Bandoh, Shuji, Ishii, Tomoya, Dobashi, Hiroaki, Matsunaga, Takuya“…PURPOSE: No lung cancer xenograft model using non-obese diabetic (NOD)-scid Il2rg(−/−) mice has been reported. …”
Publicado 2014
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196756por ter Braak, Bas, Siezen, Christine, Speksnijder, Ewoud N, Koedoot, Esmee, van Steeg, Harry, Salvatori, Daniela CF, van de Water, Bob, van der Laan, Jan Willem“…INTRODUCTION: Insulin analogues are structurally modified molecules with altered pharmaco-kinetic and -dynamic properties compared to regular human insulin used by diabetic patients. While these compounds are tested for undesired mitogenic effects, an epidemiological discussion is ongoing regarding an association between insulin analogue therapy and increased cancer incidence, including breast cancer. …”
Publicado 2015
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196757por Simpkin, Arabella, Cochran, Elaine, Cameron, Fergus, Dattani, Mehul, de Bock, Martin, Dunger, David B., Forsander, Gun, Guran, Tulay, Harris, Julie, Isaac, Iona, Hussain, Khalid, Kleta, Robert, Peters, Catherine, Tasic, Velibor, Williams, Rachel, Yap Kok Peng, Fabian, O'Rahilly, Stephan, Gorden, Philipp, Semple, Robert K., Bockenhauer, Detlef“…Normotension and stable glomerular function with only moderate proteinuria is in contrast to genetically modified mice who have elevated BP and progressive diabetic nephropathy.…”
Publicado 2014
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196758“…Vision was assessed with a Snellen chart, Early Treatment of Diabetic Retinopathy Study (ETDRS) style logMAR letter chart and logMAR chart using Landolt rings. …”
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196759por Tricco, Andrea C, Cogo, Elise, Isaranuwatchai, Wanrudee, Khan, Paul A, Sanmugalingham, Geetha, Antony, Jesmin, Hoch, Jeffrey S, Straus, Sharon E“…Based on these, 22 interventions were found to be more effective and less costly (i.e., dominant) compared to the study comparators: 9 for diabetic ulcers, 8 for venous ulcers, 3 for pressure ulcers, 1 for mixed venous and venous/arterial ulcers, and 1 for mixed complex wound types. …”
Publicado 2015
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196760por Jamal, Omar, Aneni, Ehimen C, Shaharyar, Sameer, Ali, Shozab S, Parris, Don, McEvoy, John W, Veledar, Emir, Blaha, Michael J, Blumenthal, Roger S, Agatston, Arthur S, Conceição, Raquel D, Feldman, Theodore, Carvalho, Jose A, Santos, Raul D, Nasir, Khurram“…METHODS: We evaluated 5,503 healthy non-diabetic Brazilian subjects (mean age of 43 ± 10 years, 79% males). …”
Publicado 2014
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