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  1. 196741
    “…The latter has been implicated in the abnormal vascular responsiveness to endothelin-1 and angiotensin II in diabetic-hypertensive rats. Intrinsic synergy involving IMPG1 on chromosome 6q14.2-q15 was also verified. …”
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    Genome-Wide Association Study of Young-Onset Hypertension in the Han Chinese Population of Taiwan
  2. 196742
    “…No change in Tusc5 mRNA or protein levels was evident in type 2 diabetic patients treated with pioglitazone. Tusc5 expression was not induced appreciably in liver preparations overexpressing PPARs, suggesting that tissue-specific factors regulate PPARγ responsiveness of the TUSC5 gene. …”
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    Molecular Characterization of the Tumor Suppressor Candidate 5 Gene: Regulation by PPARγ and Identification of TUSC5 Coding Variants in Lean and Obese Humans
  3. 196743
    “…METHODS: The SPs from luminal-type BC were analysed for BC T-IC characteristics, including human epidermal growth factor receptor 2 (HER2), ERα, IGFBP7 expression and their ability to initiate tumours in non-obese diabetic severe combined immunodeficiency (NOD/SCID) mice. …”
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    Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling
  4. 196744
    “…They have various biological functions including anti-oxidant, anti-microbial, anti-inflammation, anti-diabetic and anti-tumor activity. Previously, we have reported that anti-cancer effect of cinnamon extracts is associated with modulation of angiogenesis and effector function of CD8(+ )T cells. …”
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    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
  5. 196745
    “…Halofuginone (HF), a low-molecular-weight alkaloid that modulates TGFβ signaling, was used to treat APL cell lines and non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice subjected to transplantation with leukemic cells from human chorionic gonadotrophin-PML-RARα transgenic mice (TG). …”
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    Halofuginone Has Anti-Proliferative Effects in Acute Promyelocytic Leukemia by Modulating the Transforming Growth Factor Beta Signaling Pathway
  6. 196746
    “…RESULTS: There were fewer diabetic patients and higher incidence of previous angina and multi-vessel disease in group II. …”
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    Serial Plasma Levels of Angiogenic Factors in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
  7. 196747
    “…Among patients there was no correlation of LVMI or the M/V ratio with diabetic or hypertensive status, but the mutation load and NMDAS correlated with the LVMI (r = 0.71 and r = 0.79, respectively, both P < 0.001). …”
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    Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers(†)
  8. 196748
    “…FGF21 is a novel secreted protein with robust anti-diabetic, anti-obesity, and anti-atherogenic activities in preclinical species. …”
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    Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21
  9. 196749
    “…Patients with SA (n=142, 20%) were more likely to be male, diabetic, and hypertensive and have an increased pulmonary artery pressure, right ventricular volume, atrial dimensions, and left ventricular mass. …”
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    Effect of Sleep Apnea and Continuous Positive Airway Pressure on Cardiac Structure and Recurrence of Atrial Fibrillation
  10. 196750
    “…Positive health outcomes were shown in 12 studies, where the clinical outcomes for diabetic patients (HbA1c level) and for asthmatic patients (forced expiratory volume [FEV]) improved. …”
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    The Effects on Health Behavior and Health Outcomes of Internet-Based Asynchronous Communication Between Health Providers and Patients With a Chronic Condition: A Systematic Review
  11. 196751
    “…BACKGROUND: Miglitol is an oral anti-diabetic drug that acts by inhibiting carbohydrate absorption in the small intestine. …”
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    Miglitol increases energy expenditure by upregulating uncoupling protein 1 of brown adipose tissue and reduces obesity in dietary-induced obese mice
  12. 196752
    “…Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation by improving insulin sensitivity. …”
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    Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells
  13. 196753
    “…BACKGROUND: Tef (Eragrostis tef), an indigenous cereal critical to food security in the Horn of Africa, is rich in minerals and protein, resistant to many biotic and abiotic stresses and safe for diabetics as well as sufferers of immune reactions to wheat gluten. …”
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    Genome and transcriptome sequencing identifies breeding targets in the orphan crop tef (Eragrostis tef)
  14. 196754
    “…RESULTS: We followed 3,583 non-diabetic subjects (4.7 years of follow-up, 123 deaths). …”
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    A High Dietary Glycemic Index Increases Total Mortality in a Mediterranean Population at High Cardiovascular Risk
  15. 196755
    “…PURPOSE: No lung cancer xenograft model using non-obese diabetic (NOD)-scid Il2rg(−/−) mice has been reported. …”
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    Higher susceptibility of NOD/LtSz-scid Il2rg(−/−) NSG mice to xenotransplanted lung cancer cell lines
  16. 196756
    “…INTRODUCTION: Insulin analogues are structurally modified molecules with altered pharmaco-kinetic and -dynamic properties compared to regular human insulin used by diabetic patients. While these compounds are tested for undesired mitogenic effects, an epidemiological discussion is ongoing regarding an association between insulin analogue therapy and increased cancer incidence, including breast cancer. …”
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    Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53(R270H/+)WAPCre mouse model
  17. 196757
    “…Normotension and stable glomerular function with only moderate proteinuria is in contrast to genetically modified mice who have elevated BP and progressive diabetic nephropathy.…”
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    Insulin Receptor and the Kidney: Nephrocalcinosis in Patients with Recessive INSR Mutations
  18. 196758
    “…Vision was assessed with a Snellen chart, Early Treatment of Diabetic Retinopathy Study (ETDRS) style logMAR letter chart and logMAR chart using Landolt rings. …”
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    Advising patients on visual fitness to drive: implications of revised DVLA regulations
  19. 196759
    “…Based on these, 22 interventions were found to be more effective and less costly (i.e., dominant) compared to the study comparators: 9 for diabetic ulcers, 8 for venous ulcers, 3 for pressure ulcers, 1 for mixed venous and venous/arterial ulcers, and 1 for mixed complex wound types. …”
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    A systematic review of cost-effectiveness analyses of complex wound interventions reveals optimal treatments for specific wound types
  20. 196760
    “…METHODS: We evaluated 5,503 healthy non-diabetic Brazilian subjects (mean age of 43 ± 10 years, 79% males). …”
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    Cigarette smoking worsens systemic inflammation in persons with metabolic syndrome
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