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196821“…The HD patients were divided into primary kidney disease (KD), hypertensive KD, diabetic KD (DM-KD) and unknown etiology subgroups according to the primary etiology of renal failure. …”
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196822por Kasuya, Goro, Tsuji, Hiroshi, Nomiya, Takuma, Makishima, Hirokazu, Haruyama, Yasuo, Kobashi, Gen, Ebner, Daniel K., Hayashi, Kazuhiko, Omatsu, Tokuhiko, Kishimoto, Riwa, Yasuda, Shigeo, Igarashi, Tatsuo, Oya, Mototsugu, Akakura, Koichiro, Suzuki, Hiroyoshi, Ichikawa, Tomohiko, Shimazaki, Jun, Kamada, Tadashi“…In 4 of 5 patients with definitive renal comorbidities, including diabetic nephropathy, sclerotic kidney or solitary kidney pre‐CIRT progressed to grade 4 chronic kidney disease (CKD). …”
Publicado 2018
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196823por Frosina, Guido, Ravetti, Jean Louis, Corvò, Renzo, Fella, Mauro, Garrè, Maria Luisa, Levrero, Fabrizio, Marcello, Diana, Marubbi, Daniela, Morana, Giovanni, Mussap, Michele, Neumaier, Carlo Emanuele, Profumo, Aldo, Raso, Alessandro, Rosa, Francesca, Vagge, Stefano, Vecchio, Donatella, Verrico, Antonio, Zona, Gianluigi, Daga, Antonio“…Orthotopic HGG were developed in immunodeficient non-obese diabetic-severe combined immunodeficient (NOD-SCID) mice by intracranial injection of primary GIC isolated from the adult glioblastoma COMI (acronym of patient’s name) and the pediatric anaplastic astrocytoma 239/12. …”
Publicado 2018
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196824por Honma, Midori, Sawada, Shojiro, Ueno, Yoshiyuki, Murakami, Keigo, Yamada, Tetsuya, Gao, Junhong, Kodama, Shinjiro, Izumi, Tomohito, Takahashi, Kei, Tsukita, Sohei, Uno, Kenji, Imai, Junta, Kakazu, Eiji, Kondo, Yasuteru, Mizuno, Kei, Kawagishi, Naoki, Shimosegawa, Tooru, Katagiri, Hideki“…SUBJECTS/METHODS: We examined mRNA expressions of key molecules for insulin signaling, gluconeogenesis and lipogenesis in human liver biopsy samples obtained from 51 non-diabetic subjects: 9 healthy controls and 42 NAFLD patients, and analyzed associations of these molecules with each other and with detailed pathological and clinical biochemistry data. …”
Publicado 2018
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196825por de Mey, Sven, Jiang, Heng, Corbet, Cyril, Wang, Hui, Dufait, Inès, Law, Kalun, Bastien, Estelle, Verovski, Valeri, Gevaert, Thierry, Feron, Olivier, De Ridder, Mark“…Background and Purpose: The anti-diabetic biguanide drugs metformin and phenformin exhibit antitumor activity in various models. …”
Publicado 2018
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196826por Shi, Bingyu, Qi, Jingjing, Yao, Genhong, Feng, Ruihai, Zhang, Zhuoya, Wang, Dandan, Chen, Chen, Tang, Xiaojun, Lu, Liwei, Chen, Wanjun, Sun, Lingyun“…After co-culturing with MSCs, IL-12 mRNA transcripts in mouse and human DCs were detected. Non-obese diabetic (NOD) mice received MSCT, recombinant IL-12, or anti-IL-12 mAb treatment, respectively. …”
Publicado 2018
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196827por Martin-Castillo, Begoña, Pernas, Sonia, Dorca, Joan, Álvarez, Isabel, Martínez, Susana, Pérez-Garcia, Jose Manuel, Batista-López, Norberto, Rodríguez-Sánchez, César A., Amillano, Kepa, Domínguez, Severina, Luque, Maria, Stradella, Agostina, Morilla, Idoia, Viñas, Gemma, Cortés, Javier, Cuyàs, Elisabet, Verdura, Sara, Fernández-Ochoa, Álvaro, Fernández-Arroyo, Salvador, Segura-Carretero, Antonio, Joven, Jorge, Pérez, Elsa, Bosch, Neus, Garcia, Margarita, López-Bonet, Eugeni, Saidani, Samiha, Buxó, Maria, Menendez, Javier A.“…None of the serious AEs was deemed to be metformin-related. Addition of anti-diabetic doses of metformin to a complex neoadjuvant regimen was well tolerated and safe. …”
Publicado 2018
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196828“…BACKGROUND: Color fundus photography have been extensively used to explore the link between retinal morphology changes associated with various disease i.e. Diabetic Retinopathy, Glaucoma. The development of multimodal imaging system that integrates Infrared Scanning Laser Ophthalmoscope (IR-SLO) and Optical Coherence Tomography (OCT) could help in studying these diseases at an early stage. …”
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196829“…Kyoto Encyclopedia of Genes and Genomes analysis showed that target genes of miR-4792 were enriched in aminoacyltRNA biosynthesis, AGE–RAGE signaling pathway in diabetic complications, sphingolipid signaling pathway, neuroactive ligand–receptor interaction, glycosaminoglycan degradation, and regulation of lipolysis in adipocytes. …”
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196830por Kaiser, Peter K, Kodjikian, Laurent, Korobelnik, Jean-Francois, Winkler, Julia, Torri, Albert, Zeitz, Oliver, Vitti, Robert, Ahlers, Cristiane, Zimmermann, Torsten, Dicioccio, A Thomas, Höchel, Joachim“…OBJECTIVE: Explore relationships between systemic exposure to intravitreal aflibercept injection (IAI) and systemic pharmacodynamic effects via post hoc analyses of clinical trials of IAI for neovascular age-related macular degeneration (nAMD) or diabetic macular oedema (DME). METHODS AND ANALYSIS: Adults from VGFT-OD-0702.PK (n=6), VGFT-OD-0512 (n= 5), VIEW 2 (n=1204) and VIVID-DME (n=404) studies were included. …”
Publicado 2019
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196831“…These differentiated cells exhibited the angiogenesis potential in vitro, and injection of these differentiated cells enhanced angiogenesis in the ischemic hindlimb of diabetic mice. Furthermore, it was found that hypoxia increased significantly EphrinB2 expression EC differentiation, which is greatly downregulated with EphrinB2 blockage. …”
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196832por Filhoulaud, Gaelle, Benhamed, Fadila, Pagesy, Patrick, Bonner, Caroline, Fardini, Yann, Ilias, Anissa, Movassat, Jamileh, Burnol, Anne-Françoise, Guilmeau, Sandra, Kerr-Conte, Julie, Pattou, François, Issad, Tarik, Postic, Catherine“…Interestingly, expression and O-GlcNAcylation of TxNIP appeared to be increased in islets of diabetic rodents. At the mechanistic level, the induction of the O-GlcNAcylation pathway in human and rat islets promotes inflammasome activation as evidenced by enhanced cleaved IL1β. …”
Publicado 2019
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196833por Jasrotia, Rahul Singh, Yadav, Pramod Kumar, Iquebal, Mir Asif, Bhatt, S B, Arora, Vasu, Angadi, U B, Tomar, Rukam Singh, Jaiswal, Sarika, Rai, Anil, Kumar, Dinesh“…It is further valuable because of therapeutic attributes due to its antioxidant and anti-diabetic properties. A highly diverse and an extremely ecological niche of different species can be valuable genomic resources for productivity enhancement. …”
Publicado 2019
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196834por Zhang, Bing, Zhang, Ping, Tan, Yanzhen, Feng, Pan, Zhang, Zhengbin, Liang, Hongliang, Duan, Weixun, Jin, Zhenxiao, Wang, Xiaowu, Liu, Jincheng, Gao, Erhe, Yu, Shiqiang, Yi, Dinghua, Sun, Yang, Yi, Wei“…C1q-tumor necrosis factor-related protein-3 (CTRP3) is an adipokine, which exerts protective function in ischemic or diabetic heart injury. However, the role of CTRP3 in cardiac hypertrophy remains unclear. …”
Publicado 2019
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196835“…PURPOSE: To measure the choroidal thickness in patients with high myopia from staphyloma using swept source OCT (SS-OCT) in Early Treatment Diabetic Retinopathy Study (ETDRS) fields and compare to normal cohort. …”
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196836por Chambers, Edward S, Byrne, Claire S, Morrison, Douglas J, Murphy, Kevin G, Preston, Tom, Tedford, Catriona, Garcia-Perez, Isabel, Fountana, Sofia, Serrano-Contreras, Jose Ivan, Holmes, Elaine, Reynolds, Catherine J, Roberts, Jordie F, Boyton, Rosemary J, Altmann, Daniel M, McDonald, Julie A K, Marchesi, Julian R, Akbar, Arne N, Riddell, Natalie E, Wallis, Gareth A, Frost, Gary S“…OBJECTIVE: To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses. DESIGN: Twelve non-diabetic adults with overweight and obesity received 20 g/day of inulin-propionate ester (IPE), designed to selectively deliver propionate to the colon, a high-fermentable fibre control (inulin) and a low-fermentable fibre control (cellulose) in a randomised, double-blind, placebo-controlled, cross-over design. …”
Publicado 2019
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196837“…CONCLUSION: In conclusion, the results confirm that food waste can be used in the synthesis of AgNPs and that the latter have the potential for applications in various fields including diabetic and cancer treatments as well as in biomedicine for the manufacture of antibacterial coatings in medical devices and instruments.…”
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196838por Ohno, Yui, Seki, Tomohiro, Kojima, Yu, Miki, Ryotaro, Egawa, Yuya, Hosoya, Osamu, Kasono, Keizo, Seki, Toshinobu“…BACKGROUND: Multiple daily subcutaneous injections (MDSIs) are mainly used for formulating an insulin therapy for diabetic patients; however, they also cause insulin-derived amyloidosis (IDA) and lead to poor glycemic control. …”
Publicado 2019
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196839por Shah, Fawad Ali, Li, Tao, Kury, Lina Tariq Al, Zeb, Alam, Khatoon, Shehla, Liu, Gongping, Yang, Xifei, Liu, Fang, Yao, Huo, Khan, Arif-Ullah, Koh, Phil Ok, Jiang, Yuhua, Li, Shupeng“…This study was designed to delineate the molecular, pathological, and neurological changes in rat models of t-MCAO, permanent MCAO (pMCAO), and pMCAO with diabetic conditions in hippocampal tissue. Our results showed that these three models showed distinct discrepancies at numerous pathological process, including key signaling molecules involved in neuronal apoptosis, glutamate induced excitotoxicity, neuroinflammation, oxidative stress, and neurotrophic changes. …”
Publicado 2019
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196840por Fidalgo, Bruno R, Dabasia, Priya, Jindal, Anish, Edgar, David F, Ctori, Irene, Peto, Tunde, Lawrenson, John G“…Subjects were classified as presence or absence of sight-threatening eye disease (clinically significant cataract, primary open-angle glaucoma, intermediate or advanced age-related macular degeneration and significant diabetic retinopathy). Univariate and multivariate logistic regression analyses were used to determine the association between abnormal screening test results and the presence of sight-threatening eye disease. …”
Publicado 2019
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