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197181por Arora, Tulika, Wegmann, Udo, Bobhate, Anup, Lee, Ying Shiuan, Greiner, Thomas U., Drucker, Daniel J., Narbad, Arjan, Bäckhed, Fredrik“…OBJECTIVE: The enteroendocrine hormone glucagon-like peptide 1 (GLP-1) is an attractive anti-diabetic therapy. Here, we generated a recombinant Lactococcus lactis strain genetically modified to produce GLP-1 and investigated its ability to improve glucose tolerance in mice on chow or high-fat diet (HFD). …”
Publicado 2016
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197182“…BACKGROUND: Pregabalin is approved by the US Food and Drug Administration for the treatment of fibromyalgia (FM), diabetic peripheral neuropathy (DPN), postherpetic neuralgia (PHN), and neuropathic pain due to spinal cord injury (SCI). …”
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197183por Makino, Naohiko, Shirahata, Nakao, Honda, Teiichiro, Ando, Yoshiaki, Matsuda, Akiko, Ikeda, Yushi, Ito, Miho, Nishise, Yuko, Saito, Takafumi, Ueno, Yoshiyuki, Kawata, Sumio“…The study involved 551 participants older than 40 year of age. Data for 472 non-diabetic adults were included in the analysis. The measures included the demographic factors, blood parameters, results of a 75 g oral glucose tolerance test, and abdominal ultrasonography. …”
Publicado 2016
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197184por Kalender, Günay, Kornberger, Angela, Lisy, Milan, Beiras-Fernandez, Andres, Stock, Ulrich A“…More profound upregulated levels of CD45−CD34+/CD133+ cells were observed for diabetic (+47% compared to nondiabetic) and male (+38% compared to female) patients. …”
Publicado 2016
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197185“…Metformin is a common anti-diabetic drug. The objective is to evaluate the protective effects of metformin on ileal epithelial barrier integrity using interleukin-10 deficient (IL10KO) mice. …”
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197186por Netala, Vasudeva Reddy, Kotakadi, Venkata Subbaiah, Gaddam, Susmila Aparna, Ghosh, Sukhendu Bikash, Tartte, Vijaya“…Gymnema sylvestre R.Br. is an important medicinal plant, rich in a group of oleanane triterpenoid saponins called gymnemic acid, well known for its anti-diabetic activity. Two endophytic fungal strains were isolated from the leaves of G. sylvestre and identified as Polyancora globosa and Xylaria sp. based on the PCR amplification and internal transcribed spacer (ITS 1-5.8S-ITS 2) sequencing of 18S rRNA gene. …”
Publicado 2016
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197187“…BACKGROUND: The receptor for advanced glycosylation end products (RAGE) has been widely linked to diabetic atherosclerosis, but its effects on coronary artery disease (CAD) and ischemic stroke (IS) remain controversial. …”
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197188por Khayyat, Sarah M., Khayyat, Salwa M. Saeed, Hyat Alhazmi, Raghda S., Mohamed, Mahmoud M. A., Abdul Hadi, Muhammad“…Female gender (OR 0.40 [95% CI: 0.20–0.80; P = 0.01]), Age > 65 years (OR 2.0 [95% CI: 1.0–4.2; P = 0.04]), and being diabetic (OR 0.25 [95% CI: 0.1–0.6; P = 0.04]) were found to be independent predictors of medication adherence. …”
Publicado 2017
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197189por Margolis, Jay M, Princic, Nicole, Smith, David M, Abraham, Lucy, Cappelleri, Joseph C, Shah, Sonali N, Park, Peter W“…METHODS: Using medical and pharmacy health care claims from the MarketScan® Commercial and Medicare Supplemental Databases, patients were selected during July 1, 2010, to June 30, 2012, with the following chronic pain conditions: osteoarthritis (OA), gout (GT), painful diabetic peripheral neuropathy (pDPN), post-herpetic neuralgia (PHN), and fibromyalgia (FM). …”
Publicado 2017
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197190por Bielesz, Bernhard, Patsch, Janina M., Fischer, Lukas, Bojic, Marija, Winnicki, Wolfgang, Weber, Michael, Cejka, Daniel“…Increased cortical porosity (Ct.Po) has been shown to be associated with fracture in patients with osteopenia or in postmenopausal diabetic women. We tested whether the degree of Ct.Po identifies hemodialysis patients with prevalent fragility fractures in comparison to bone mineral density (BMD) assessed by dual X-ray absorptiometry (DXA). …”
Publicado 2017
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197191por Hebbal, Veeresh Patil, Setty, Huliyurdurga Srinivasasetty Natraj, Sathvik, Cholenahalli Manjunath, Patil, Vikram, Sahoo, Sarthak, Manjunath, Cholenahalli Nanjappa“…RESULTS: Of the 209 patients, 85.1% were males and 35.8% were diabetic, 60.2% were smokers, AWMI accounted for 55.5%. …”
Publicado 2017
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197192“…Application of autologous Platelet Rich Plasma (PRP) has been a major breakthrough for the treatment of non-healing and diabetic foot ulcers, as it is an easy and cost-effective method, and provides the necessary growth factors that enhance tissue healing. …”
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197193por Günaydın, Zeki Yüksel, Karagöz, Ahmet, Bektaş, Osman, Kaya, Ahmet, Kırış, Tuncay, Erdoğan, Güney, Işık, Turgay, Ayhan, Erkan“…When the subgroups were analyzed, the SCORE model was found to be better in predicting coronary artery disease extent and severity in subgroups of men and diabetics {[AUC=0.737 (0.668, 0.844) vs. 0.665 (0.560, 0.790), p=0.019], [AUC=0.733 (0.684, 0.798) vs. 0.680 (0.654, 0.750) p=0.029], respectively). …”
Publicado 2016
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197194por Li, Zhengmao, Wu, Fenzan, Zhang, Xie, Chai, Yi, Chen, Daqing, Yang, Yuetao, Xu, Kebin, Yin, Jiayu, Li, Rui, Shi, Hongxue, Wang, Zhouguang, Li, Xiaokun, Xiao, Jian, Zhang, Hongyu“…Endoplasmic reticulum (ER) stress-induced apoptosis plays an important role in a range of neurological disorders, such as neurodegenerative diseases, spinal cord injury, and diabetic neuropathy. Valproate (VPA), a typical antiepileptic drug, is commonly used in the treatment of bipolar disorder and epilepsy. …”
Publicado 2017
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197195por Rajagopalan, Viswanathan, Zhang, Youhua, Pol, Christine, Costello, Clifford, Seitter, Samantha, Lehto, Ann, Savinova, Olga V., Chen, Yue-feng, Gerdes, A. Martin“…Background: We have shown that thyroid hormones (THs) are cardioprotective and can be potentially used as safe therapeutic agents for diabetic cardiomyopathy and permanent infarction. However, no reliable, clinically translatable protocol exists for TH treatment of myocardial ischemia-reperfusion (IR) injury. …”
Publicado 2017
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197196por Yokoyama, Masayuki, Chiba, Tetsuhiro, Zen, Yoh, Oshima, Motohiko, Kusakabe, Yuko, Noguchi, Yoshiko, Yuki, Kaori, Koide, Shuhei, Tara, Shiro, Saraya, Atsunori, Aoyama, Kazumasa, Mimura, Naoya, Miyagi, Satoru, Inoue, Masanori, Wakamatsu, Toru, Saito, Tomoko, Ogasawara, Sadahisa, Suzuki, Eiichiro, Ooka, Yoshihiko, Tawada, Akinobu, Otsuka, Masayuki, Miyazaki, Masaru, Yokosuka, Osamu, Iwama, Atsushi“…Intraperitoneal administration of BIX-01294 suppressed the growth of xenograft tumors generated by implantation of HCC cells in non-obese diabetic/severe combined immunodeficient mice. Immunohistochemical analyses revealed high levels of G9a and H3K9me2 in 36 (66.7%) and 35 (64.8%) primary HCC tissues, respectively. …”
Publicado 2017
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197197por Chen, Chia-Chen, Agrawal, Dinesh Chandra, Lee, Maw-Rong, Lee, Ren-Jye, Kuo, Chao-Lin, Wu, Chi-Rei, Tsay, Hsin-Sheng, Chang, Hung-Chi“…BACKGROUND: Peucedanum japonicum Thunb, an important medicinal herb is reported to possess pharmacological properties such as anti-obesity, anti-oxidant, anti-inflammatory, anti-bacterial, anti-diabetic and anti-platelet aggregation. The present study aimed to develop an in vitro plant regeneration system of P. japonicum via somatic embryogenesis and to analyse chlorogenic acid and rutin contents in a few commercially available plant products of P. japonicum in Japan and Taiwan markets, and tissue culture plants derived from somatic embryos. …”
Publicado 2016
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197198por Al-Debasi, Tariq, Al-Bekairy, Abdulkareem, Al-Katheri, Abdulmalik, Al Harbi, Shmeylan, Mansour, Mahmoud“…Moreover, at worse levels of initial visual acuity of diabetic macular edema, aflibercept was more effective at improving vision. …”
Publicado 2017
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197199“…OBJECTIVE: Although adipose tissue hydrogen peroxide (H(2)O(2)) and its metabolizing enzymes have been linked to obesity and insulin resistance in animal studies, this relation remains to be evaluated in humans. METHODS: Non-diabetic men (N = 43, median age, 49 (37, 54 y)) undergoing abdominal surgeries were studied. …”
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197200por Bonner, Nicola, Panter, Charlotte, Kimura, Alan, Sinert, Rich, Moellman, Joseph, Bernstein, Jonathan A.“…With ever-widening indications for ACEI in diseases including hypertension, congestive heart failure and diabetic nephropathy, a concomitant increase in ACEI-Angioedema (ACEI-A) has been reported. …”
Publicado 2017
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