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197541por Van Acker, Nathalie, Ragé, Michael, Sluydts, Ellen, Knaapen, Michiel W. M., De Bie, Martine, Timmers, Maarten, Fransen, Erik, Duymelinck, Carla, De Schepper, Stefanie, Anand, Praveen, Meert, Theo, Plaghki, Léon, Cras, Patrick“…Next, the diagnostic performance and yield of the LDT were explored and challenged to the gold standard using skin punch biopsies of capsaicin treated subjects, and patients with diabetic polyneuropathy. The LDT reached good agreement with the gold standard in identifying small fiber neuropathy. …”
Publicado 2016
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197542por Kostich, Walter, Hamman, Brian D., Li, Yu-Wen, Naidu, Sreenivasulu, Dandapani, Kumaran, Feng, Jianlin, Easton, Amy, Bourin, Clotilde, Baker, Kevin, Allen, Jason, Savelieva, Katerina, Louis, Justin V., Dokania, Manoj, Elavazhagan, Saravanan, Vattikundala, Pradeep, Sharma, Vivek, Das, Manish Lal, Shankar, Ganesh, Kumar, Anoop, Holenarsipur, Vinay K., Gulianello, Michael, Molski, Ted, Brown, Jeffrey M., Lewis, Martin, Huang, Yanling, Lu, Yifeng, Pieschl, Rick, O’Malley, Kevin, Lippy, Jonathan, Nouraldeen, Amr, Lanthorn, Thomas H., Ye, Guilan, Wilson, Alan, Balakrishnan, Anand, Denton, Rex, Grace, James E., Lentz, Kimberley A., Santone, Kenneth S., Bi, Yingzhi, Main, Alan, Swaffield, Jon, Carson, Ken, Mandlekar, Sandhya, Vikramadithyan, Reeba K., Nara, Susheel J., Dzierba, Carolyn, Bronson, Joanne, Macor, John E., Zaczek, Robert, Westphal, Ryan, Kiss, Laszlo, Bristow, Linda, Conway, Charles M., Zambrowicz, Brian, Albright, Charles F.“…Further studies showed that the inhibitor also reduced evoked pain responses in the rat chronic constriction injury (CCI) model and the rat streptozotocin model of diabetic peripheral neuropathy. Using a nonbrain-penetrant AAK1 inhibitor and local administration of an AAK1 inhibitor, the relevant pool of AAK1 for antineuropathic action was found to be in the spinal cord. …”
Publicado 2016
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197543por Irawati, Deasy, Mamo, John C. L., Dhaliwal, Satvinder S., Soares, Mario J., Slivkoff-Clark, Karin M., James, Anthony P.“…Remnants of postprandial lipoproteins show potent atherogenicity in cell and animal models of insulin resistance and in pre-diabetic subjects with postprandial dyslipidemia. However, few studies have considered regulation of chylomicron remnant homeostasis in MetS per se. …”
Publicado 2016
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197544por Ishibashi, Yuji, Matsui, Takanori, Isami, Fumiyuki, Abe, Yumi, Sakaguchi, Tatsuya, Higashimoto, Yuichiro, Yamagishi, Sho-ichi“…BACKGROUND: Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. …”
Publicado 2017
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197545por Gilron, Ian, Tu, Dongsheng, Holden, Ronald, Towheed, Tanveer, Ziegler, Dan, Wang, Louie, Milev, Roumen, Gray, Christopher“…Alpha-lipoic acid (ALA) is an antioxidant proven effective in painful diabetic neuropathy with minimal side effects. OBJECTIVE: We hypothesize that this agent will provide benefits in fibromyalgia because of several similarities with neuropathic pain and also because it does not cause sedation, fatigue, or mental-slowing. …”
Publicado 2017
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197546por Peppers, Timothy A., Bullard, Dennis E., Vanichkachorn, Jed S., Stanley, Scott K., Arnold, Paul M., Waldorff, Erik I., Hahn, Rebekah, Atkinson, Brent L., Ryaby, James T., Linovitz, Raymond J.“…Subgroup analysis of subjects with risk factors for pseudoarthrosis (current or former smokers, diabetic, or obese/extremely obese) compared to those without risk factors demonstrated no significant differences in fusion rates. …”
Publicado 2017
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197547por Liu, Long, Wang, Qian, Wang, Qianqian, Zhao, Xing, Zhao, Pan, Geng, Tuoyu, Gong, Daoqing“…RESULTS: Our data showed that miR29c expression was comprehensively inhibited in energy homeostasis-related tissues (the liver, fat and muscle) of overfed vs. normally fed geese, which is different from miR29c induction that occurs in tissues of the diabetic rat. To address the function of miR29c, three predicted target genes (i.e., Insig1, Sgk1 and Col3a1) that participate in energy homeostasis or cell growth were validated by a dual-fluorescence reporter system and other in vitro assays. …”
Publicado 2018
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197548por Petrera, Marilena, Paleari, Laura, Clavarezza, Matteo, Puntoni, Matteo, Caviglia, Silvia, Briata, Irene Maria, Oppezzi, Massimo, Mislej, Eva Mihajlovic, Stabuc, Borut, Gnant, Michael, Bachleitner-Hofmann, Thomas, Roth, Wilfried, Scherer, Dominique, Haefeli, Walter-E., Ulrich, Cornelia M., DeCensi, Andrea“…Metformin has also been associated with decreased colon adenoma recurrence in clinical trials and lower CRC incidence and mortality in epidemiological studies in diabetics. While both drugs have been tested as single agents, their combination has not been tested in cancer prevention trials. …”
Publicado 2018
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197549por Kim, Seoyoung C., Di Carli, Marcelo F., Garg, Rajesh K., Vanni, Kathleen, Wang, Penny, Wohlfahrt, Alyssa, Yu, Zhi, Lu, Fengxin, Campos, Anarosa, Bibbo, Courtney F., Smith, Stacy, Solomon, Daniel H.“…In multivariable linear regression analyses, SUA had no association with CFR (β = − 0.12, p = 0.78) or stress MBF (β = − 0.52, p = 0.28). Among non-diabetic patients (n = 25), SUA was not associated with HOMA-IR (β = 2.08, p = 0.10). …”
Publicado 2018
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197550por Grune, Jana, Ritter, Daniel, Kräker, Kristin, Pappritz, Kathleen, Beyhoff, Niklas, Schütte, Till, Ott, Christiane, John, Cathleen, van Linthout, Sophie, Tschöpe, Carsten, Dechend, Ralf, Muller, Dominik N., Haase, Nadine, Grune, Tilman, Kintscher, Ulrich, Kuebler, Wolfgang M.“…Auto2DE allowed for valid detection of impaired cardiac function in animal models with pronounced cardiac phenotypes, but yielded poor performance in diabetic animal models independent of image quality. …”
Publicado 2019
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197551por Droguett, Alejandra, Valderrama, Graciela, Burgos, María E., Carpio, Daniel, Saka, Constanza, Egido, Jesús, Ruiz-Ortega, Marta, Mezzano, Sergio“…Gremlin renal overexpression has been reported in diabetic nephropathy, pauci-immune crescentic glomerulonephritis and chronic allograft nephropathy and has been implicated in the pathophysiology of the progression of renal damage. …”
Publicado 2019
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197552por Qian, Weibin, Cai, Xinrui, Qian, Qiuhai, Zhuang, Qianzhu, Yang, Wenjun, Zhang, Xinying, Zhao, Lijie“…Purpose: Functional impairment of endothelial progenitor cells (EPCs) is frequently observed in patients with diabetic vascular complications. Astragaloside IV (ASV) has a significant protective effect against vascular endothelial dysfunction. …”
Publicado 2019
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197553por Cooke, Matthew D., Winter, Patricia A., McKenney, Kaitlin C., Packard, Krissa L., Williams, Vesper, Dorsey, Eleanor A., Szabo, Aniko, Visotcky, Alexis, Warren, Clinton C., Wirostko, William J., Weinberg, David V., Kim, Judy E., Han, Dennis P.“…OBJECTIVE: We evaluated the Runge card, a near-vision eye chart designed for ease of use, by testing agreement in visual acuity results between it and the Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity chart. …”
Publicado 2019
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197554por Yarjanli, Zahra, Ghaedi, Kamran, Esmaeili, Abolghasem, Zarrabi, Ali, Rahgozar, Soheila“…BACKGROUND: We recently showed that quercetin-conjugated iron oxide nanoparticles (QNPs) promoted the bioavailability of quercetin (Qu) in the brain of rats and improved the learning and memory of diabetic rats. In this study, we characterized the modifications in the antitoxic effects of Qu after conjugation. …”
Publicado 2019
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197555por Eriksson, Olof, Velikyan, Irina, Haack, Torsten, Bossart, Martin, Evers, Andreas, Laitinen, Iina, Larsen, Philip J., Plettenburg, Oliver, Takano, Akihiro, Halldin, Christer, Antoni, Gunnar, Johansson, Lars, Pierrou, Stefan, Wagner, Michael“…The glucagon receptor (GCGR) is an emerging target in anti-diabetic therapy. Reliable biomarkers for in vivo activity on the GCGR, in the setting of dual glucagon-like peptide 1/glucagon (GLP-1/GCG) receptor agonism, are currently unavailable. …”
Publicado 2019
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197556por Ajmera, Prakash, Pothineni, Ramesh, Chawla, Kamal Kumar, Mantravadi, Sai Sudhakar, Jariwala, Pankaj Vinod, Vijan, Vinod, Vijan, Vikrant“…A subgroup analysis between diabetic and nondiabetic patients did not reveal any statistically significant difference for clinical outcomes at 6-month follow-up. …”
Publicado 2019
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197557por Islam, Md Nahidul, Griffin, Tomás P., Sander, Elizabeth, Rocks, Stephanie, Qazi, Junaid, Cabral, Joana, McCaul, Jasmin, McMorrow, Tara, Griffin, Matthew D.“…BACKGROUND: Renal proximal tubular epithelial cells (RPTEC) are dysfunctional in diabetic kidney disease (DKD). Mesenchymal stromal cells (MSC) may modulate DKD pathogenesis through anti-inflammatory mediators. …”
Publicado 2019
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197558por Ranjan, Amit, Singh, Rajesh Kumar, Khare, Saumya, Tripathi, Ruchita, Pandey, Rajesh Kumar, Singh, Anurag Kumar, Gautam, Vibhav, Tripathi, Jyoti Shankar, Singh, Santosh Kumar“…The study highlights the importance of endophytic fungi as an alternative source of AGI (α-glucosidase inhibition) to control the diabetic condition in vitro.…”
Publicado 2019
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197559por Coma, Ermengol, Medina, Manuel, Méndez, Leonardo, Hermosilla, Eduardo, Iglesias, Manuel, Olmos, Carmen, Calero, Sebastian“…The most effective reminder was screening for diabetic retinopathy (OR 1.51, 95% CI:1.46–1.57) while the least effective reminders were measurement of glycated hemoglobin (OR: 1.10, 95% CI: 1.07–1.13) and smoking cessation encouragement (OR 1.12, 95% CI: 1.09–1.16). …”
Publicado 2019
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197560por Si, Jiahui, Ma, Yuanyuan, Bi, Ji Wang, Xiong, Ying, Lv, Chao, Li, Shaolei, Wu, Nan, Yang, Yue“…Tumorigenesis and therapeutic effects were investigated in nonobese diabetic/severe combined immunodeficiency (nod-scid) mice. …”
Publicado 2019
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