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1por Danzer, Steve C.Enlace del recurso
Publicado 2019
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4“…However, extensive research over the last few years have elucidated that certain tumor suppressor genes do not conform to these standard definitions and might act as “double agents”, playing contrasting roles in vivo in cells, where either due to haploinsufficiency, epigenetic hypermethylation, or due to involvement with multiple genetic and oncogenic events, they play an enhanced proliferative role and facilitate the pathogenesis of cancer. …”
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5“…On the other hand, since chronic inflammation is a well-recognized condition that promotes tumor development, it appears that autoimmunity can be a “double agent” in mediating either pro-tumor or antitumor effects. …”
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7“…Finally, our results suggest that the functionally altering mutations in “double-agent” genes and oncogenes are the main driving force in cancer development, because non-silent mutations are biasedly distributed toward these two gene sets across all 12 major cancer types.…”
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11por Clark, Phillip“…This paper explores what being a “double agent of aging” means as an individual and a scholar, and offers some insights for the field of gerontology. …”
Publicado 2020
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15“…Additionally, CHIP can play its dual role as a tumor suppressor as well as an oncogene in numerous malignancies, thus acting as a double agent. Here, in this review, we have reported almost all substrates of CHIP established till date and classified them according to the hallmarks of cancer. …”
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16“…In this review, we summarized SPDEF as the double agent involving in expression profiles, the regulatory mechanism in BC progression, as well as the role in diagnosis, treatment and prognosis of BC. …”
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20por Tukaj, StefanEnlace del recurso
Publicado 2020
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