“…However, obtaining functional gametes from pluripotent stem cells still remains a distant dream and major bottle-neck appears to be their inefficient differentiation into primordial germ cells (PGCs). …”
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“…RESULTS: Here we present a novel scalable algorithm for identifying genome-wide gene regulatory network (GRN) structures, and we have verified the algorithm performances by extensive simulation studies based on the DREAM challenge benchmark data. The highlight of our method is that its superior performance does not degenerate even for a network size on the order of 10(4), and is thus readily applicable to large-scale complex networks. …”
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“…To fill this gap, we quantified germline leakage across 259 sets of whole-genome somatic single nucleotide variant (SNVs) predictions made by 21 teams as part of the ICGC-TCGA DREAM Somatic Mutation Calling Challenge. RESULTS: The median somatic SNV prediction set contained 4325 somatic SNVs and leaked one germline polymorphism. …”
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“…Furthermore, eIF4G1 was over-expressed and or amplified, in 16% patients with metastatic PCa (SU2C/PCF Dream Team dataset) and in 59% of castration-resistant prostate cancer (CRPC) patients (Trento/Cornell/Broad dataset). …”
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“…We then organize and enable a crowdsourced benchmarking within the ICGC-TCGA DREAM Somatic Mutation Calling Challenge (SMC-DNA). …”
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“…The spontaneous speech during three tasks (describing a complex picture, a typical working day and recalling a last remembered dream) was then recorded, transcribed and annotated at various linguistic levels. …”
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“…Rapid eye movement sleep behavior disorder is parasomnia characterized by symptoms of dream enactment and loss of muscle atonia during rapid eye movement sleep. …”
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“…The trained classifier can also be used to generate synthetic spectrograms using the DeepDream algorithm to study what time-frequency features are relevant for classification. …”
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“…TRIAL REGISTRATION: The DREAM cohort study is registered in the Netherlands Trial Register: NTR578.…”
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“…Access to safe drinking water is still a distant dream to millions of people around the world. Especially, people from the low-income group in the developing countries remain deprived of this fundamental right and causes millions of death. …”
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“…Independently of the many controversies (be these scientific, psychological or even ethical) about the soundness and real outcomes that such ideas can bring to improve learning, it’s a worthy intriguing research area for many researchers pursuing the ideal automated teacher: the teachbot dream. Behind this goal we have developed Middle, a Moodle plug-in able to infer the learning style of each student taking a course using an advanced version of a Bayesian network model that we previously tested. …”
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“…The participants envisioned completing their education, focusing on their dream careers, and contributing positively to society. …”
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“…Our analyses were performed using a supercomputing DreamLab App platform, harnessing the idle computational power of thousands of smartphones. …”
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“…A shamanic-informed psychedelic therapy includes: a preparatory set with practices such as sexual abstinence, fasting and dream incubation; a set derived from innate modular cognitive capacities and their integration expressed in a relational animistic worldview; a focus on internal imagery manifesting a presentational intelligence; and spirit relations involving incorporation of animals as personal powers. …”
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“…These results are corroborated using another gene expression platform (NanoString(TM)) and by analysis of RNA-Seq data from patients with mCRPC (SU2C- PCF Dream Team). We next quantify AR-V expression in matching EpCAM-positive vs EpCAM-negative CTCs, as EpCAM-based CTC enrichment is commonly used. …”
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“…Upregulation of FOXM1 expression and DREAM-complex repression have shown phenotypical subgroups correlating with WHO grade and aggressiveness. …”
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“…CONCLUSION: Taken together, our data suggest that mutation-specific TCRs can be used to target the MyD88 L265P mutation, and hold promise for precision therapy in a significant subgroup of B-cell malignancies, possibly achieving the goal of absolute tumor specificity, a long sought-after dream of immunotherapy.…”
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“…We apply our method to O’Neil’s high-throughput drug combination screening data as well as a dataset from the AstraZeneca-Sanger Drug Combination Prediction DREAM Challenge. We compare the neural network approach with and without dimension reduction. …”
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“…Additionally, we advocate that a thorough psychological and trauma history be undertaken in all patients presenting with dream enactment behaviors (DEB).…”
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“…Methods: This was a cross-sectional study derived from our prospective cohort study, named DREAM, of Japanese HD patients. After the exclusion of patients with treated and untreated thyroid dysfunction, 332 patients were analyzed in the study. …”
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