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  1. 56641
    “…Comorbidities in ADD caused by autosomal dominant mutations such as those in the presenilin-1 (PSEN1) gene may provide an advantageous perspective on their pathogenesis, and deserve attention because these subjects are increasingly being entered into clinical trials. As ADD associated with PSEN1 mutations has a presumed single-cause etiology, and the average age at death is under 60, any comorbidities in this setting may be considered as at least partially secondary to the causative AD mechanisms rather than aging, and thus indicate whether effective ADD therapeutics may also be effective for comorbidities. …”
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    Comorbidities in Early-Onset Sporadic versus Presenilin-1 Mutation-Associated Alzheimer’s Disease Dementia: Evidence for Dependency on Alzheimer’s Disease Neuropathological Changes
  2. 56642
    “…Methods: In B2219, participants (Pts) with acromegaly or CD who did not need therapy for hyperglycemia or were managed with metformin alone entered the non-randomized observational arm. Pts who developed hyperglycemia not managed with metformin alone were randomized to incretin-based therapy or insulin. …”
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    THU054 A Post Hoc Analysis Of The Phase IV B2219 Study To Determine Predictive Factors For Hyperglycemia During Treatment With Pasireotide
  3. 56643
    “…High-dose diazoxide, everolimus, dexamethasone, glucagon, pasireotide, or enteral feeding did not produce a response. Despite multiple therapies, neuroglycopenia required frequent dextrose boluses and continuous intravenous glucose (up to 30 g/hr of 50% dextrose); up to 58% of sensor glucose was below 70 mg/dL and 19% below 54 mg/dL over 24 hours. …”
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    FRI603 Treatment Of Severe Refractory Hypoglycemia Due To Malignant Insulinoma With A Novel Anti-insulin Receptor Antibody
  4. 56644
    por Coleman, R, Bell, RM
    Publicado 1978
    “…Uncharged molecules of up to approximately 600 daltons are able to enter the lumen of rat liver microsomes, but macromolecules and charged molecules of low molecular weight do not cross the vesicle membrane (10, 11). …”
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    Evidence that biosynthesis of phosphatidylethanolamine, phosphatidylcholine, and triacylglycerol occurs on the cytoplasmic side of microsomal vesicles
  5. 56645
    por Auer, J., Gates, Frederick L.
    Publicado 1916
    “…Intratracheal injection is perhaps better under the conditions mentioned than the intravenous route, for the surface veins cannot always be entered with promptness and certainty even under fairly normal conditions, and in cases of cardiac weakness the difficulties will be measurably increased, while an intratracheal injection can be carried out with ease. …”
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    THE ABSORPTION OF ADRENALIN AFTER INTRATRACHEAL INJECTION
  6. 56646
    por Jones, F. S.
    Publicado 1926
    “…During the next few days a continual supply of antibody enters the circulation and during the period there is a steady utilization of the antigenic substance; it is possible that during this time there is constant union of antigen and antibody within the blood, with the slow utilization of the antigen and a slight utilization of the antibody which is made up by a slow increase from the body cells. …”
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    THE BEHAVIOR IN VIVO OF CERTAIN RELATIVELY PURE ANTIGENS
  7. 56647
    por Brand, Richard A.
    Publicado 2008
    “…He was, however, a captain in the military reserve and when the United States entered WW I, he resigned his position at the hospital and his professorship at the University of Kansas Medical School, and went to England with the unit that Dr. …”
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    The Use of Sulfathiazole in the Treatment of Subacute and Chronic Osteomyelitis*: Frank D. Dickson MD (1882–1964), Rex L. Diveley MD, Richard Kiene MD The 4th President of the AAOS 1935 (FDD)
  8. 56648
    por Brand, Richard A.
    Publicado 2008
    “…I sometimes feel that in our post-war fervor, in behalf of the veterans separated from military service, we tend to encourage some conscientious young men to enter a field of training for which they are totally unsuited.” …”
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    Clinical and Experimental Observations with Regard to the Injection of Certain Agents (Pregl’s Solution) into Chronic Arthritic Joints: J. E. M. Thomson MD (1889–1962) The 14th President of the AAOS 1946
  9. 56649
    por Bärnighausen, Till, Bloom, David E
    Publicado 2009
    “…Financial incentives for return of service are intended to alleviate health worker shortages: A (future) health worker enters into a contract to work for a number of years in an underserved area in exchange for a financial pay-off. …”
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    Financial incentives for return of service in underserved areas: a systematic review
  10. 56650
    “…Results In the summer wave of A/H1N1 influenza, 0.54% (95% credible interval 0.33% to 0.82%) of the estimated 606 100 (419 300 to 886 300) symptomatic cases were hospitalised, 0.05% (0.03% to 0.08%) entered intensive care, and 0.015% (0.010% to 0.022%) died. …”
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    Changes in severity of 2009 pandemic A/H1N1 influenza in England: a Bayesian evidence synthesis
  11. 56651
    “…A case definition was created by ASPR field teams to identify which encounter visits would be entered into the electronic medical record (EMR) and received in ESSENCE-FL. …”
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    Operational Experience: Integration of ASPR Data into ESSENCE-FL during the RNC
  12. 56652
    “…All patients will be diagnosed using the Diagnostic Interview for Genetic Studies (DIGS) and will then enter a 2-year follow-up period on lithium monotherapy if and when they exhibit a score of 1 (normal, not ill), 2 (minimally ill) or 3 (mildly ill) on the Clinical Global Impressions of Severity Scale for Bipolar Disorder (CGI-S-BP Overall Bipolar Illness) for 4 of the 5 preceding weeks. …”
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    The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample
  13. 56653
    “…METHODS: After a 2-week screening period, adult patients (aged 36–72 years) entered a 4-week run-in/stabilization period. Then, patients were randomly assigned to either the intervention group (n = 55) or the control group (n = 50) for 26 weeks. …”
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    The effect of alogliptin on pulmonary function in obese patients with type 2 diabetes inadequately controlled by metformin monotherapy
  14. 56654
    “…Given this issue, it is important from both a research and clinical standpoint to determine what characteristics are associated with treatment utilization in addition to merely asking individuals if they wish to enter treatment. At the level of clinical research, if there are phenotypic differences between treatment and nontreatment-seekers that directly influence outcomes of early-phase studies, these phenotypic differences are a potential confound in assessing the utility of an experimental treatment for AUD. …”
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    Using Machine Learning to Classify Individuals With Alcohol Use Disorder Based on Treatment Seeking Status
  15. 56655
    “…Women also show lower pharmacological treatment effectiveness as they are less likely to feel satisfied upon entering a substance abuse treatment and they show higher cravings. …”
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    2198: Gender differences in the pharmacology of buprenorphine sublingual tablets in Hispanics/Latinos: An underrepresented population
  16. 56656
    “…BACKGROUND: The Global Enteric Multicenter Study (GEMS) was a 3-year case-control study that measured the burden, aetiology, and consequences of moderate-to-severe diarrhoea (MSD) in children aged 0–59 months. …”
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    Diarrhoeal disease and subsequent risk of death in infants and children residing in low-income and middle-income countries: analysis of the GEMS case-control study and 12-month GEMS-1A follow-on study
  17. 56657
    “…The substantial number of patients not entering this trial randomisation following induction therapy, however, might support the use of combination therapies upfront to maximise response and improve outcomes as is now the standard of care in the UK. …”
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    Response-adapted intensification with cyclophosphamide, bortezomib, and dexamethasone versus no intensification in patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial
  18. 56658
    “…The collected data were entered into EpiData, and analysis was conducted using Statistical Package for Social Sciences (SPSS) version 22. …”
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    Prevalence and associated factors of undernutrition among under-five children from model and non-model households in east Gojjam zone, Northwest Ethiopia: a comparative cross-sectional study
  19. 56659
    “…The cardiovascular risk profile deteriorates after women enter menopause. By definition, women diagnosed with premature ovarian insufficiency (POI) experience menopause before 40 years of age, which may render these women even more susceptible to develop CVD later in life. …”
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    The cardiovascular risk profile of middle age women previously diagnosed with premature ovarian insufficiency: A case-control study
  20. 56660
    “…CONCLUSION: Prediction models for covid-19 are quickly entering the academic literature to support medical decision making at a time when they are urgently needed. …”
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    Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal
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